The neuroendocrine system of invertebrates: a developmental and evolutionary perspective

Hartenstein, Volker

doi:10.1677/joe.1.06964

Cited by 246 publications

(225 citation statements)

References 125 publications

(114 reference statements)

Supporting

Mentioning

216

Contrasting

Unclassified

Order By: Relevance

“…Our rationale was based on the idea that conserved transcription modules-which consist of a transcription factor with conserved co-factors, conserved binding site and conserved targets-exist in the evolutionarily conserved control of development 15 and behaviour 16,18 . We found that a conserved transcription factor, Tll, and its conserved co-repressor, Atro, indeed affect aggression in flies and that this transcriptional repressor complex acts through a set of adult neurosecretory cells known as the PI, which has remarkable similarity to the mammalian hypothalamus 31 , a brain region known for its critical role in the control of aggressive behaviour in mammals [33][34][35]44 . Moreover, we found that electrical activation of these neurons is sufficient to cause an increase in aggression in flies, just like electrical stimulation of the hypothalamus does in mammals [33][34][35] .…”

Section: Discussionmentioning

confidence: 93%

“…2a,b and Supplementary Fig. 4), a brain region composed of B200 neurosecretory cells that has been suggested to be functionally equivalent to the hypothalamus based on molecular, structural and developmental data 31 . Interestingly, mouse Nr2e1 is expressed in the adult hypothalamus 28 , which is known for its important regulatory role in mammalian aggression 43,44 .…”

Section: Resultsmentioning

confidence: 99%

“…These neurons have been suggested to be part of an ancient neuro-endocrine axis shared between vertebrates and invertebrates 68 . Multiple lines of evidence have suggested that the PI-corpora cardiaca system has structural, developmental and functional similarities with the mammalian hypothalamic-pituitary axis 31,68 . Electrical and optogenetic stimulation of the mammalian hypothalamus leads to a strong increase in aggression in a wide range of mammalian species [33][34][35] .…”

Section: Article Nature Communications | Doi: 101038/ncomms4177mentioning

confidence: 99%

“…In the adult fly brain, Tailless localizes to the neurosecretory cells of the pars intercerebralis (PI), a brain region with functional, developmental and structural similarities to the mammalian hypothalamus 31 . Knockdown of tll specifically in the PI causes aggression and can be rescued by coexpression of human NR2E1.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis

et al. 2014

View full text Add to dashboard Cite

Aggressive behaviour is widespread throughout the animal kingdom. However, its mechanisms are poorly understood, and the degree of molecular conservation between distantly related species is unknown. Here we show that knockdown of tailless (tll) increases aggression in Drosophila, similar to the effect of its mouse orthologue Nr2e1. Tll localizes to the adult pars intercerebralis (PI), which shows similarity to the mammalian hypothalamus. Knockdown of tll in the PI is sufficient to increase aggression and is rescued by co-expressing human NR2E1. Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI. In addition, genetically activating PI neurons increases aggression, mimicking the aggression-inducing effect of hypothalamic stimulation. Together, our results suggest that a transcriptional control module regulates neuropeptide signalling from the neurosecretory cells of the brain to control aggressive behaviour.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Article Nature Communications | Doi: 101038/ncomms4177mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…As modulators of neuronal activity, neuropeptides contribute to the generation of different outputs from the same neuronal circuit in a context-dependent manner (9), or orchestrate complex motor programs (10). Many neuropeptides act as hormones and are released into the haemolymph by neurohemal organs, such as the vertebrate pituitary gland, or the insect corpora cardiaca (11). These peptide hormones regulate various aspects of physiology, including growth, metabolism, and reproduction.…”

mentioning

confidence: 99%

Global view of the evolution and diversity of metazoan neuropeptide signaling

Jékely

2013

Proc. Natl. Acad. Sci. U.S.A.

384

635

View full text Add to dashboard Cite

Neuropeptides are signaling molecules that commonly act via G protein-coupled receptors (GPCRs) and are generated in neurons by proneuropeptide (pNP) cleavage. Present in both cnidarians and bilaterians, neuropeptides represent an ancient and widespread mode of neuronal communication. Due to the inherent difficulties of analyzing highly diverse and repetitive pNPs, the relationships among different families are often elusive. Using similarity-based clustering and sensitive similarity searches, I obtained a global view of metazoan pNP diversity and evolution. Clustering revealed a large and diffuse network of sequences connected by significant sequence similarity encompassing one-quarter of all families. pNPs belonging to this cluster were also identified in the early-branching neuronless animal Trichoplax adhaerens. Clustering of neuropeptide GPCRs identified several orthology groups and allowed the reconstruction of the phyletic distribution of receptor families. GPCR phyletic distribution closely paralleled that of pNPs, indicating extensive conservation and long-term coevolution of receptor-ligand pairs. Receptor orthology and intermediate sequences also revealed the homology of pNPs so far considered unrelated, including allatotropin and orexin. These findings, together with the identification of deuterostome achatin and luqin and protostome opioid pNPs, extended the neuropeptide complement of the urbilaterian. Several pNPs were also identified from the hemichordate Saccoglossus kowalevskii and the cephalochordate Branchiostoma floridae, elucidating pNP evolution in deuterostomes. Receptor-ligand conservation also allowed ligand predictions for many uncharacterized GPCRs from nonmodel species. The reconstruction of the neuropeptide-signaling repertoire at deep nodes of the animal phylogeny allowed the formulation of a testable scenario of the evolution of animal neuroendocrine systems.Platynereis | proenkephalin | Petromyzon N europeptides are diverse neuron-secreted peptides with neuromodulatory, neurotransmitter, or hormonal functions. Most neuropeptides signal via G protein-coupled receptors (GPCRs) (1), with a few exceptions (2-8). As modulators of neuronal activity, neuropeptides contribute to the generation of different outputs from the same neuronal circuit in a context-dependent manner (9), or orchestrate complex motor programs (10). Many neuropeptides act as hormones and are released into the haemolymph by neurohemal organs, such as the vertebrate pituitary gland, or the insect corpora cardiaca (11). These peptide hormones regulate various aspects of physiology, including growth, metabolism, and reproduction. Active neuropeptides are generated from an inactive proneuropeptide (pNP) that contains a single or multiple copies of active peptides. Active peptides are commonly short, with only a few families adopting well-defined, but unrelated, folds (e.g., prolactin and glycoprotein hormones). pNPs have a signal peptide (SP) and enter the secretory apparatus where dedicated proteases cleave them at mono...

show abstract

Arthropoda

Smolowitz

2021

Invertebrate Histology

View full text Add to dashboard Cite

The neuroendocrine system of invertebrates: a developmental and evolutionary perspective

Cited by 246 publications

References 125 publications

Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis

Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis

Global view of the evolution and diversity of metazoan neuropeptide signaling

Arthropoda

Contact Info

Product

Resources

About