The neurobiology of binge-like ethanol drinking: Evidence from rodent models

Sprow, Gretchen M.; Thiele, Todd E.

doi:10.1016/j.physbeh.2011.12.026

Cited by 88 publications

(71 citation statements)

References 70 publications

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“…Because rodents are nocturnally active, the drinking-in-the-dark (DID) model is used to examine binge-like ethanol consumption during periods of darkness. [33][34][35] EtOH conditioning in the dark chamber leads to arousal effects in mice and influences the rewarding effects of EtOH, as seen in the present study.…”

Section: Discussionsupporting

confidence: 73%

Factors Affecting Ethanol-Induced Conditioned Place Preference and Locomotor Sensitization in Mice

Shimizu

Oki

Mitani

et al. 2015

Biological & Pharmaceutical Bulletin

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The rewarding effects of alcohol can lead to progressively heavier and more frequent drinking. Since studies of reward have mainly focused on responses to higher alcohol doses, the relations between reward and moderate/sustained alcohol exposure remain unknown. Our objective was to evaluate factors affecting the reward value of low alcohol doses and risk factors for increasing alcohol doses due to reward progression caused by alcohol exposure patterns. We thus performed conditioned place preference (CPP) and ethanol (EtOH)-induced locomotor sensitization tests in mice. Low-dose EtOH (0.5 or 1 g/kg twice/week)-induced CPP was stronger than that produced by saline control treatment, but the effect decreased with increasing numbers of conditioning trials. Moderate-dose/long-term EtOH exposure induced a weaker CPP than high-dose/short-term EtOH (2 g/kg twice/week) exposure with the same total EtOH dose (8 g/kg/experiment). Acamprosate calcium, an anti-relapse drug, preclusively reduced EtOH-induced CPP. EtOH induced CPP and locomotor sensitization in black but not white chamber, although the initial preference and the basal locomotion in each chamber were equal. Therefore the brightness of the chamber had an effect on EtOHinduced sensitization. Moreover, additional studies indicated that EtOH-induced locomotor sensitization also depends on the dose but not the administration interval. Paired associative learning with EtOH exposure is a potent factor influencing the level of reward produced by EtOH. Moreover, exposure to high doses of alcohol, even on an intermittent schedule, carries a higher risk of addiction than exposure to moderate doses over longer periods.Key words moderate alcohol (ethanol: EtOH); conditioned place preference (CPP); reward; sensitization; paired associative learning Alcohol abuse is associated with serious physical and psychiatric illnesses, financial hardships, familial dysfunction, and violence, all of which place a substantial burden on society. Heavy alcohol consumption and long-term drinking increase the risk of alcohol-related diseases such as liver cirrhosis, cancer, pancreatitis, and depression. 1,2) In response, the World Health Organization (WHO) recently approved a Global Strategy to Reduce Harmful Use of Alcohol urging all countries to strengthen national responses to public health problems caused by alcohol use.3) In Japan, 6.45 million people suffer from alcohol-related problems, with an estimated annual economic loss of 4.15 trillion yen associated with alcohol. 4) In December 2013, the Basic Act on Measures against Alcohol-related Health Harm was enacted in Japan, promoting education about drinking in moderation to prevent alcoholrelated problems.Regular consumption of alcohol increases the propensity for addiction because of the rewarding effects of alcohol. Thus, many casual drinkers gradually increase total alcohol consumption, which becomes habitual over time. Although many studies in rodents have been conducted on chronic drinking and reward, 5-7) previous studies have ma...

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Section: Discussionsupporting

confidence: 73%

Factors Affecting Ethanol-Induced Conditioned Place Preference and Locomotor Sensitization in Mice

Shimizu

Oki

Mitani

et al. 2015

Biological & Pharmaceutical Bulletin

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“…Kong et al [2010] found that blocking the activity of these neurons in D. melanogaster attenuated the stimulant response to ethanol, and that the attenuated stimulant response to ethanol in flies lacking a D1-like dopamine receptor could be rescued by selective expression of the receptor in the ellipsoid body. These findings are consistent with a well-established role for dopamine in mediating ethanol-related behaviors in rodents and flies [Crabbe et al, 2006;Phillips and Shen, 1996;Scholz, 2009;Sprow and Thiele, 2012], which is in turn consistent with the model of Strausfeld and Hirth [2013] of conserved locomotorgenerating circuitry in arthropods and vertebrates.…”

Section: P O C C I D E N T a L I S M D I G I T A T A B G E R Msupporting

confidence: 89%

Conservation of the Ethanol-Induced Locomotor Stimulant Response among Arthropods

Kliethermes

2015

Brain Behav Evol

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Ethanol-induced locomotor stimulation has been variously described as reflective of the disinhibitory, euphoric, or reinforcing effects of ethanol and is commonly used as an index of acute ethanol sensitivity in rodents. The fruit fly Drosophila melanogaster also shows a locomotor stimulant response to ethanol that is believed to occur via conserved, ethanol-sensitive neurobiological mechanisms, but it is currently unknown whether this response is conserved among arthropod species or is idiosyncratic to D. melanogaster. The current experiments surveyed locomotor responses to ethanol in a phylogenetically diverse panel of insects and other arthropod species. A clear ethanol-induced locomotor stimulant response was seen in 9 of 13 Drosophilidae species tested, in 8 of 10 other species of insects, and in an arachnid (wolf spider) and a myriapod (millipede) species. Given the diverse phylogenies of the species that showed the response, these experiments support the hypothesis that locomotor stimulation is a conserved behavioral response to ethanol among arthropod species. Further comparative studies are needed to determine whether the specific neurobiological mechanisms known to underlie the stimulant response in D. melanogaster are conserved among arthropod and vertebrate species.

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“…This drinking pattern has been shown to produce cognitive deficits and motivational alterations following repeated alcohol exposure (Bechara et al, 2001;Harper and Matsumoto, 2005;Stephens and Duka, 2008;Sprow and Thiele, 2012;Cippitelli et al, 2014;Townshend et al, 2014). The combination of alcoholic beverages and energy drinks (EDs) has been suggested to favor binge drinking because of increased palatability (e.g., the sweet taste) and the common misconception that EDs antagonize the depressant effects of alcohol.…”

Section: Introductionmentioning

confidence: 99%

Binge-like ingestion of a combination of an energy drink and alcohol leads to cognitive deficits and motivational changes

Takahashi

Vendruscolo

Takahashi

2015

Pharmacology Biochemistry and Behavior

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The combination of alcohol with an energy drink (ED) is believed to contribute to risky alcohol-drinking behaviors, such as binge drinking. However, the long-term effects on cognition and reward function that are caused by the repeated binge-like ingestion of alcohol and EDs are still poorly known. The present study examined the effects of a history of repeated exposure to alcohol and/or an ED on short-term memory and alcohol-seeking behavior. Male Wistar rats were given daily intragastric administration of alcohol (3.4g/kg) combined or not with an ED (10.71ml/kg) for 6 consecutive days. The rats were tested for locomotion 15min after the first intragastric treatment. Short-term memory was assessed in the novel object recognition and social discrimination tests 2-3days after the last intragastric administration. The rewarding effect of alcohol was tested 1-3weeks following the last intragastric administration in a conditioned place preference paradigm. The acute binge-like ingestion of alcohol decreased locomotor activity, whereas the combination of alcohol and an ED increased locomotion in the first minutes of assessment. Alcohol exposure produced cognitive deficits in both the object recognition and social discrimination tests, and adding the ED to the alcohol solution did not modify these effects. The combination of alcohol and the ED increased alcohol-induced conditioned place preference. Thus, a history of binge-like alcohol exposure combined with the ED caused subsequent cognitive deficits and increased alcohol seeking behavior, and such behavioral effects might contribute to the progression to alcohol abuse disorders.

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The neurobiology of binge-like ethanol drinking: Evidence from rodent models

Cited by 88 publications

References 70 publications

Factors Affecting Ethanol-Induced Conditioned Place Preference and Locomotor Sensitization in Mice

Factors Affecting Ethanol-Induced Conditioned Place Preference and Locomotor Sensitization in Mice

Conservation of the Ethanol-Induced Locomotor Stimulant Response among Arthropods

Binge-like ingestion of a combination of an energy drink and alcohol leads to cognitive deficits and motivational changes

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