The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder

Lee, Bernard T.; Cho, Seong Whi; Khang, Hyung Soo; Lee, Boung-Chul; Choi, Ihn-Geun; Lyoo, In Kyoon; Ham, Byung Joo

doi:10.1016/j.pnpbp.2007.06.030

Cited by 86 publications

(59 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although at this point speculative, these observations could indicate that in depressed women the left Cg25 modulates intense visceral emotional responses to aversive visual stimuli by limiting their neuronal impact. This corresponds to earlier reports of decreased left sided limbic activation patterns in response to negative stimuli in majorly depressed patients (Davidson et al, 2003;Lee et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Baeken

Schuerbeek

Raedt

et al. 2010

Journal of Affective Disorders

View full text Add to dashboard Cite

Background: Research regarding the neurocircuitry in mood disorders suggests an important role for affective information processing of the subgenual part of the anterior cingulate cortex (Cg25: Brodmann area 25).Objective: In this study, we focused on Cg25 neuronal responses in depressed females using a paradigm in which emotions are elicited without explicit cognitive control, relying on the salient nature of the mood inducing stimuli eliciting approach-related emotions (like happiness) or withdrawal-related emotions (like disgust).Methods: Twelve treatment-resistant melancholic depressed women and 12 healthy female control subjects were asked to passively view blocks of emotionally valenced baby faces while undergoing functional magnetic resonance imaging (fMRI).Results: Compared to the healthy females, the depressed patients displayed significantly higher bilateral Cg25 neuronal activities in both emotional conditions. In melancholically depressed women, we found significantly less left-sided than right-sided Cg25 neuronal activity during the withdrawal-related emotions, while right-sided Cg25 activity was comparable for both emotional responses.

show abstract

Section: Discussionsupporting

confidence: 92%

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Baeken

Schuerbeek

Raedt

et al. 2010

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

“…Recent reports have shown an altered emotion processing in depression compared with the healthy state concerning the perception and also the anticipation of emotional events (e.g. for reviews, see Drevets, 2001 ;Davidson et al 2002 ;Phillips et al 2003 ;Leppanen, 2006 ; for recent reports, see Keedwell et al 2005 ;Abler et al 2006 ;Johnstone et al 2007 ;Langenecker et al 2007 ; Lee et al 2007 ;Dannlowski et al 2008 ;Fales et al 2008 ;Grimm et al 2008 ;Knutson et al 2008 ;Mitterschiffthaler et al 2008). However, the direct comparison of anticipating events of known positive and negative valence with an unknown valence as a model of ' pessimistic ' expectation has not yet been performed in depressed patients.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of ‘pessimistic’ attitude in depression

et al. 2009

View full text Add to dashboard Cite

Background. Preparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that ' pessimism '-related emotion processing would characterize brain activity in major depression.Method. During functional magnetic resonance imaging, depressed patients and a healthy control group were cued to expect and then perceive pictures of known emotional valences -pleasant, unpleasant and neutral -and stimuli of unknown valence that could have been either pleasant or unpleasant. Brain activation associated with the ' unknown ' expectation was compared with the ' known ' expectation conditions.Results. While anticipating pictures of unknown valence, activation patterns in depressed patients within the medial and dorsolateral prefrontal areas, inferior frontal gyrus, insula and medial thalamus were similar to activations associated with expecting unpleasant pictures, but not with expecting positive pictures. The activity within a majority of these areas correlated with the depression scores. Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations.Conclusions. Brain activation in depression during expecting events of unknown emotional valence was comparable with activation while expecting certainly negative, but not positive events. This neurobiological finding is consistent with cognitive models supposing that depressed patients develop a ' pessimistic ' attitude towards events with an unknown emotional meaning. Thereby, particularly the role of brain areas associated with the processing of cognitive and executive control and of the internal state is emphasized in contributing to major depression.

show abstract

“…The underlying cause could be the impaired inhibition of negative affect, which has been found in depressed patients across several studies [17,26]. In turn, altered patterns of facial activity have been reported in those patients suffering major depressive disorders [31,32].…”

Section: A Case In Point -Facial Activity In Depression 31 the Affementioning

confidence: 99%

“…More specifically, the impaired inhibition of negative affective material could be an important cognitive factor in depressive disorders. Recent studies using functional magnetic resonance imaging (fMRI), have provided some evidence that the severity of depression in major depressive disorder (MDD) groups correlates with increased neural responses to pictures with negative content [16,26]. In turn, this bias to favour negative material by depressed patients has been shown to be signaled in the resulting facial expressions.…”

Section: Introductionmentioning

confidence: 99%

An approach for automatically measuring facial activity in depressed subjects

McIntyre

Göcke

Hyett

et al. 2009

2009 3rd International Conference on Affective Computing and Intelligent Interaction and Workshops

View full text Add to dashboard Cite

This paper is motivated by Ellgring's work in non-verbal communication in depression to measure and compare the levels of facial activity, before and after treatment, of endogenous and neurotic depressives. Similar to that work, we loosely associate the measurements with Action Units (AU) groups from the Facial Action Coding System (FACS). However, we use the neologism Region Units (RU) to describe regions of the face that encapsulate AUs. In contrast to Ellgring's approach, we automatically generate the measurements and provide both prototypical expression recognition and RU-specific activity measurements. Latency between expressions is also measured and the system is conducive to comparison across groups and individual subjects. By using Active Appearance Models (AAM) to locate the fiduciary facial points, and MultiBoost to classify prototypical expressions and the RUs, we can provide a simple, objective, flexible and cost-effective means of automatically measuring facial activity.

show abstract

The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder

Cited by 86 publications

References 33 publications

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Neural correlates of ‘pessimistic’ attitude in depression

An approach for automatically measuring facial activity in depressed subjects

Contact Info

Product

Resources

About