The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking

Hamlin, Adam; Newby, Jill M.; McNally, Gavan P.

doi:10.1016/j.neuroscience.2007.01.063

Cited by 177 publications

(233 citation statements)

References 41 publications

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“…This replicates our previously published finding that renewal of beer seeking is associated with c-Fos induction in AcbShV (Hamlin et al, 2007). A similar significant difference between groups ABA and ABB was observed for single c-Fos-IR (F (1,8) ϭ 9.2; p Ͻ 0.05).…”

Section: Distribution Of C-fos-ir In Lh and Pef Afferentssupporting

confidence: 91%

“…Figure 3F shows mean (ϮSEM) total c-Fos, single c-Fos, and dual c-Fos/CTb IR for AcbSh. Our past research has shown an important difference between c-Fos expression in ventral (AcbShV) and dorsomedial (AcbShDm) AcbSh during ABA renewal (Hamlin et al, 2007). We have previously shown that renewal associated c-Fos induction is detected only in AcbShV.…”

Section: Behaviormentioning

confidence: 92%

“…This difference was due to more variable levels of responding during extinction training in the sucrose experiment. These parameters were chosen based on our past research which shows robust acquisition, extinction, and renewal of responding under these conditions (Hamlin et al, 2006(Hamlin et al, , 2007(Hamlin et al, , 2008. At the end of extinction training, rats were allocated, based on responding during acquisition and extinction training, to one of four groups: training context A (ABA) B/M, ABA PBS, extinction context B (ABB) B/M, or ABB PBS.…”

Section: Methodsmentioning

confidence: 99%

“…used a renewal design (Bouton and Bolles, 1979) and reported that rats trained to self-administer a heroin-cocaine mixture in one context, context A, and then extinguished in a second, different context, context B, showed a pronounced reinstatement of extinguished drug seeking when tested in context A. This context-induced reinstatement or renewal of extinguished drug seeking has since been reported for a variety of drug rewards including cocaine Fuchs et al, 2007;Hamlin et al, 2008), heroin (Bossert et al, 2004), alcohol Zironi et al, 2006;Hamlin et al, 2007;Marinelli et al, 2007), and nicotine (Diergaarde et al, 2008), as well as the natural reward sucrose (Hamlin et al, 2006). Renewal is a signature phenomenon of extinction (Bouton, 2002).…”

Section: Introductionmentioning

confidence: 90%

“…Recently, we have used c-Fos expression to identify the neural correlates of context-induced reinstatement. We have characterized these correlates for renewal of cocaine (Hamlin et al, 2008), alcoholic beer (Hamlin et al, 2007), and sucrose (Hamlin et al, 2006) seeking. In each case, renewal was selectively associated with c-Fos induction in lateral hypothalamus (LH).…”

Section: Introductionmentioning

confidence: 99%

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Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

2009

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We studied the role of lateral hypothalamus (LH) in context-induced reinstatement (renewal) of reward seeking. Rats were trained to respond for 4% (v/v) alcoholic beer or 10% (w/v) sucrose reward in one context (Context A) before extinction training in a second context (Context B). On test, rats were returned to the training context, A (ABA), or the extinction context, B (ABB). Return to the training context (ABA) produced robust reinstatement. Reversible inactivation of LH via baclofen/muscimol infusion prevented context-induced reinstatement of beer and sucrose seeking. This prevention was specific to bilateral infusions into LH. We then used the retrograde neuronal tracer cholera toxin b subunit (CTb) combined with detection of the c-Fos protein to identify activated afferents to LH during contextinduced reinstatement of beer seeking. Double labeling for c-Fos and CTb revealed a significant recruitment of LH-projecting neurons in nucleus accumbens shell (AcbSh) during reinstatement. These afferents could be classified into two anatomically and functionally distinct groups. First, afferents in the ventral AcbSh projecting to LH were activated during reinstatement. Second, afferents in the dorsomedial AcbSh projecting to LH were activated during test in the extinction context. These recruitments were specific to an AcbSh-LH pathway because they were not observed following CTb injection into the immediately adjacent perifornical hypothalamus. These results show that LH is critical for context-induced reinstatement of reward seeking and that parallel striatal-hypothalamic pathways are recruited following return to the training versus extinction contexts.

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Section: Distribution Of C-fos-ir In Lh and Pef Afferentssupporting

confidence: 91%

Section: Behaviormentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

2009

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A Contemporary Behavioral Perspective on Extinction

Vurbic¹,

Bouton²

2014

The Wiley Blackwell Handbook of Operant and Classical Conditioning

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Identification of discrete, intermingled hypocretin neuronal populations

Iyer

Essner

Klingenberg

et al. 2018

J of Comparative Neurology

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Neurons in the lateral hypothalamic area that express hypocretin (Hcrt) neuropeptides help regulate many behaviors including wakefulness and reward seeking. These neurons project throughout the brain, including to neural populations that regulate wakefulness, such as the locus coeruleus (LC) and tuberomammilary nucleus (TMN), as well as to populations that regulate reward, such as the nucleus accumbens (NAc) and ventral tegmental area (VTA). To address the roles of Hcrt neurons in seemingly disparate behaviors, it has been proposed that Hcrt neurons can be anatomically subdivided into at least two distinct subpopulations: a "medial group" that projects to the LC and TMN, and a "lateral group" that projects to the NAc and VTA. Here, we use a dual retrograde tracer strategy to test the hypotheses that Hcrt neurons can be classified based on their downstream projections and medial/lateral location within the hypothalamus. We found that individual Hcrt neurons were significantly more likely to project to both the LC and TMN or to both the VTA and NAc than would be predicted by chance. In contrast, we found that Hcrt neurons that projected to the LC or TMN were mostly distinct from Hcrt neurons that projected to the VTA or NAc. Interestingly, these two populations of Hcrt neurons are intermingled within the hypothalamus and cannot be classified into medial or lateral groups. These results suggest that Hcrt neurons can be distinguished based on their downstream projections but are intermingled within the hypothalamus.

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The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking

Cited by 177 publications

References 41 publications

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

A Contemporary Behavioral Perspective on Extinction

Identification of discrete, intermingled hypocretin neuronal populations

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