The neural basis of prolonged suppression of predatory attack. I. Naturally occurring physiological differences in the limbic systems of killer and non-killer cats

Adamec, Robert E.

doi:10.1002/1098-2337(1975)1:4<315::aid-ab2480010405>3.0.co;2-1

Cited by 19 publications

(10 citation statements)

References 6 publications

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“…Since the electrostimulation-induced potentiation of pathways appears capable of mediating lasting behavioral changes, it seems possible that physiological potentiating mechanisms may underlie natural behavioral differences in animals. In support of this notion, the natural transmission efficiencies of limbic pathways were found to vary systematically with what might be described as “personality” characteristics of cats (Adamec 1975 a , 1975 b ; Adamec and Stark-Adamec 1983 c ). Upon single-pulse stimulation of the amygdala, the most defensive cats exhibited the greatest evoked synaptic responses in the ventromedial hypothalamus and relatively small responses in the ventral hippocampus.…”

Section: Brief Orientation To Neural Plasticity Researchmentioning

confidence: 76%

“…This kindling model for progressive behavioral change emphasizes a correlation between behavior and synaptic connectivity. Just as differentially aggressive cats differed naturally in the transmission efficiencies of limbic pathways (Adamec 1975 a , 1975 b ), humans with psychopathology may also have alterations in the functional connectivities of some nerve tracts.…”

Section: Neural Plasticity and Schizophrenia: Convergent Hypothesesmentioning

confidence: 99%

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Neural Plasticity in Schizophrenia

Haracz

1985

Schizophrenia Bulletin

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No current biological hypothesis can assimilate the genetic, environmental, and clinical features of schizophrenia. If, as some authors contend, environmental factors have important effects on the course of schizophrenia, then a fruitful research concern may be the adaptation of neuronal circuitry to environmental changes. The plasticity of neuronal connections has been studied by subjecting animals to neurosurgical lesions, brain electro-stimulation, and a variety of rearing environments. The present article approaches the schizophrenia research literature from a theoretical perspective which takes into account the plasticity of neuronal connections. In a speculative manner, it demonstrates how neural plasticity concepts can be invoked to explain the following seemingly disparate features of schizophrenia: the pharmacological support for the dopamine hypothesis, the delayed onset and offset of neuroleptic antipsychotic action, genetic and environmental influences in schizophrenia, the regional alterations in brain structure and function seen in chronic schizophrenic patients, and the various types of behavioral symptoms exhibited by schizophrenic patients. In view of the explanatory potential of neural plasticity concepts, a research program that focuses on these concepts seems warranted.

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Section: Brief Orientation To Neural Plasticity Researchmentioning

confidence: 76%

Section: Neural Plasticity and Schizophrenia: Convergent Hypothesesmentioning

confidence: 99%

Neural Plasticity in Schizophrenia

Haracz

1985

Schizophrenia Bulletin

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“…These effects persist interictally for weeks to months. Adamec (1975) also found that cats that scored high on measures of predatory behavior (rat killers) had high afterdischarge thresholds in the medial amygdala compared to more faarful non-killers. Ite also found that 10wer1ng afterdischarge thresholds by partially kindling the amygdala turned rat killers into fearful non-killers.…”

Section: Medial Amygdala Kindling Elicits An L!nxiogenic Responsementioning

confidence: 94%

The effect of kindling of different nuclei in the left and right amygdala on anxiety in the rat

Adamec

Morgan

1994

Physiology & Behavior

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119

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“…Finally, rat killers had the highest thresholds (ranging from 800 n A to 1800 /u A, N = 11) which also did not overlap with any of the non-killer thresholds. These threshold differences are not attributable to differences in location of electrodes of these groups (Adamec, 1975). Nor are they a function of general brain excitability differences, since no differences in thresholds in the white matter lateral to the amygdala were found (killers range 600 n A to 1800 u A, N = 5; non killers range 600 u A to 800 M A, N = 4, not significantly different) or in ventral hippocampal thresholds (killers range 200 \x A to 500 [X A, N = 5; nonkillers range 200 M A to 700 fiA, N = 12, not significantly different).…”

mentioning

confidence: 83%

Behavioral and Epileptic Determinants of Predatory Attack Behavior in the Cat

Adamec

1975

Can. j. neurol. sci.

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SUMMARY:This report presents studies which relate limbic epileptic excitability to behavioral measures of defensive suppression of predatory attack in cats. Correlated with heightened defensiveness to environmental stimuli among non-killer cats is a heightened amygdaloid epileptic excitability, as well as a heightened conduction of amygdaloid epileptic activity to thalamic and hypothalamic substrates of predatory response in the amygdala to the complex visual stimuli presented by rat prey. These neurosensory responses correlate well with measures of epileptic excitability. Brain and behavior measures appear related since enhancement of excitability in the amygdala and of projection of epileptic activity by repeated electrical stimulation of predatory attacks. Furthermore, the ventral hippocampus seems capable of antagonizing the behaviorally suppressive effects of heightened amygdaloid excitability perhaps at points of convergence of amygdaloid and hippocampal output.

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The neural basis of prolonged suppression of predatory attack. I. Naturally occurring physiological differences in the limbic systems of killer and non-killer cats

Cited by 19 publications

References 6 publications

Neural Plasticity in Schizophrenia

Neural Plasticity in Schizophrenia

The effect of kindling of different nuclei in the left and right amygdala on anxiety in the rat

Behavioral and Epileptic Determinants of Predatory Attack Behavior in the Cat

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