The neural basis of humour comprehension and humour appreciation: The roles of the temporoparietal junction and superior frontal gyrus

Campbell, Darren W.; Wallace, Marc; Modirrousta, Mandana; Polimeni, Joseph; McKeen, Nancy A.; Reiss, Jeffrey P.

doi:10.1016/j.neuropsychologia.2015.10.013

Cited by 37 publications

(16 citation statements)

References 51 publications

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“…This is consistent with previous findings on humor (Bartolo et al, 2006, Campbell et al, 2015, Goel and Dolan, 2001, Kohn et al, 2011, Mobbs et al, 2003, Samson et al, 2008, Wild et al, 2006). Our research revealed unique results since, except the left cerebellum, we did not find brain activations believed to be neural correlates of the feeling of amusement such as the rectus gyri in the orbitofrontal/ventromedial PFC, ventral ACC, insula, amygdala or parahippocampal gyri (Chan et al, 2012, Franklin and Adams, 2011, Goel and Dolan, 2001, Mobbs et al, 2003, Samson et al, 2008, Wild et al, 2006).…”

Section: Discussionsupporting

confidence: 94%

“…Furthermore, findings from parametric modulation analysis concerning subjective evaluation of the comprehensibility of stories/punchlines seem to indicate the importance of the PFC in incongruity resolution process rather than in elaboration or funniness. This is generally in line with the literature data on the role of the PFC for incongruity resolution (Campbell et al, 2015, Chan et al, 2013, Kohn et al, 2011, Samson et al, 2008, Samson et al, 2009, Wild et al, 2006). However, our findings and other research vary substantially in the PFC location, with the exception of the unequivocal dominance of the left hemisphere in successful humor comprehension process and reported activations within the MFG/SFG in the various parts of BA 8/9/10 areas.…”

Section: Discussionsupporting

confidence: 92%

“…This region is also activated during the detection and processing of unexpected stimuli, such as the process of incongruity detection and resolution (Neely et al, 2012, Vrticka et al, 2013). Other studies revealed activation of the SFG in relation to humor appreciation (Campbell et al, 2015). Neural correlates of the emotional component (e.g.…”

Section: Introductionmentioning

confidence: 93%

“…Incongruity resolution activates the left hemisphere and includes the dorsomedial MFG and Superior Frontal Gyrus (SFG), temporoparietal junction (TPJ) and precuneus (Bartolo et al, 2006, Chan et al, 2013, Marjoram et al, 2006, Samson et al, 2008, Samson et al, 2009). Successful comprehension of jokes is related to TPJ activation, which is greater if the humor content is related to ToM processing (Bartolo et al, 2006, Campbell et al, 2015, Goel and Dolan, 2001, Kohn et al, 2011, Mobbs et al, 2003, Samson et al, 2008, Wild et al, 2003). This region is also activated during the detection and processing of unexpected stimuli, such as the process of incongruity detection and resolution (Neely et al, 2012, Vrticka et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Adamczyk

Wyczesany

Domagalik

et al. 2017

NeuroImage: Clinical

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Individuals with schizophrenia exhibit problems with understanding the figurative meaning of language. This study evaluates neural correlates of diminished humor comprehension observed in schizophrenia. The study included chronic schizophrenia (SCH) outpatients (n = 20), and sex, age and education level matched healthy controls (n = 20). The fMRI punchline based humor comprehension task consisted of 60 stories of which 20 had funny, 20 nonsensical and 20 neutral (not funny) punchlines. After the punchlines were presented, the participants were asked to indicate whether the story was comprehensible and how funny it was. Three contrasts were analyzed in both groups reflecting stages of humor processing: abstract vs neutral stories - incongruity detection; funny vs abstract - incongruity resolution and elaboration; and funny vs neutral – complete humor processing. Additionally, parametric modulation analysis was performed using both subjective ratings separately. Between-group comparisons revealed that the SCH subjects had attenuated activation in the right posterior superior temporal gyrus (BA 41) in case of irresolvable incongruity processing of nonsensical puns; in the left dorsomedial middle and superior frontal gyri (BA 8/9) in case of incongruity resolution and elaboration processing of funny puns; and in the interhemispheric dorsal anterior cingulate cortex (BA 24) in case of complete processing of funny puns. Additionally, during comprehensibility ratings the SCH group showed a suppressed activity in the left dorsomedial middle and superior frontal gyri (BA 8/9) and revealed weaker activation during funniness ratings in the left dorsal anterior cingulate cortex (BA 24). Interestingly, these differences in the SCH group were accompanied behaviorally by a protraction of time in both types of rating responses and by indicating funny punchlines less comprehensible. Summarizing, our results indicate neural substrates of humor comprehension processing impairments in schizophrenia, which is accompanied by fronto-temporal hypoactivation.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Adamczyk

Wyczesany

Domagalik

et al. 2017

NeuroImage: Clinical

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“…Moreover, introspective tasks increase activity specifically in this part of SFG, with activity extending medially into BA32 (77), while damage to SFG and BA32 correlates with impairment in re-appraising the personal relevance of negative events (78). Interestingly, this part of SFG has also been implicated in expressions of positive affect such as laughter (79) and humor (80) important for self-centered re-appraisal.…”

Section: Discussionmentioning

confidence: 99%

Orbital and Medial Prefrontal Cortex Functional Connectivity of Major Depression Vulnerability and Disease

Samara

Evers

Peeters

et al. 2018

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background Pathophysiology models of major depression (MD) center on the dysfunction of various cortical areas within the orbital and medial prefrontal cortex (OMPFC). While independent structural and functional abnormalities in these areas are consistent findings in MD, the complex interactions among them and the rest of the cortex remain largely unexplored. Methods We used resting state functional magnetic resonance imaging (fMRI) connectivity to systematically map alterations in the communication between OMPFC fields and the rest of the brain in MD. Functional connectivity (FC) maps from participants with current MD (N=35), unaffected first-degree relatives (N=36) and healthy controls (N=38) were subjected to conjunction analyses to distinguish FC markers of MD vulnerability and FC markers of MD disease). Results FC abnormalities in MD vulnerability were found for dorsal medial wall regions and the anterior insula and concerned altered communication of these areas with the inferior parietal cortex and dorsal posterior cingulate, occipital areas and the brainstem. FC aberrations in current MD included the anterior insula, rostral and dorsal anterior cingulate and lateral orbitofrontal areas and concerned altered communication with the dorsal striatum, the cerebellum, the precuneus, the anterior PFC, somato-motor cortex, dorsolateral PFC, and visual areas in the occipital and inferior temporal lobes. Conclusions Functionally delineated parcellation maps can be used to identify putative connectivity markers in extended cortical regions such as the OMPFC. The anterior insula and the rostral anterior cingulate play a central role in the pathophysiology of MD, being consistently implicated both in the MD vulnerability and MD disease states.

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Representing, Detecting, and Translating Humour in the Brain

Hofmann¹,

Rodden²

2019

The Handbook of the Neuroscience of Multilingualism

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The neural basis of humour comprehension and humour appreciation: The roles of the temporoparietal junction and superior frontal gyrus

Cited by 37 publications

References 51 publications

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Orbital and Medial Prefrontal Cortex Functional Connectivity of Major Depression Vulnerability and Disease

Representing, Detecting, and Translating Humour in the Brain

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