The Netherlands Mental Health Survey and Incidence Study‐2 (NEMESIS‐2): design and methods

Graaf, Ron de; Have, Margreet ten; Dorsselaer, Saskia van

doi:10.1002/mpr.317

Cited by 189 publications

(264 citation statements)

References 79 publications

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“…We used data from the first three waves of NEMESIS-2, a prospective epidemiological cohort study in the Dutch adult general population (de Graaf et al 2010). The inclusion criterion for this study was age between 18 and 64 at the time of the baseline interview.…”

Section: Participantsmentioning

confidence: 99%

Functioning before and after a major depressive episode: pre-existing vulnerability or scar? A prospective three-wave population-based study

et al. 2018

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Background. The vulnerability hypothesis suggests that impairments after remission of depressive episodes reflect a pre-existing vulnerability, while the scar hypothesis proposes that depression leaves residual impairments that confer risk of subsequent episodes. We prospectively examined vulnerability and scar effects in mental and physical functioning in a representative Dutch population sample. Methods. Three waves were used from the Netherlands Mental Health Survey and Incidence Study-2, a population-based study with a 6-years follow-up. Mental and physical functioning were assessed with the Medical Outcomes Study Short Form (SF-36). Major depressive disorder (MDD) was assessed with the Composite International Diagnostic Interview 3.0. Vulnerability effects were examined by comparing healthy controls (n = 2826) with individuals who developed a first-onset depressive episode during first follow-up but did not have a lifetime diagnosis of MDD at baseline (n = 181). Scarring effects were examined by comparing pre-and post-morbid functioning in individuals who developed a depressive episode after baseline that was remitted at the third wave (n = 108).Results. Both mental (B = −5.4, S.E. = 0.9, p < 0.001) and physical functioning (B = −8.2, S.E. = 1.1, p < 0.001) at baseline were lower in individuals who developed a first depressive episode after baseline compared with healthy controls. This effect was most pronounced in people who developed a severe episode. No firm evidence of scarring in mental or physical functioning was found. In unadjusted analyses, physical functioning was still lowered post-morbidly (B = −5.1, S.E. = 2.1, p = 0.014), but this effect disappeared in adjusted analyses. Conclusions. Functional impairments after remission of depression seem to reflect a preexisting vulnerability rather than a scar.

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Section: Participantsmentioning

confidence: 99%

Functioning before and after a major depressive episode: pre-existing vulnerability or scar? A prospective three-wave population-based study

et al. 2018

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“…Both studies applied multistage, random sampling procedures of municipalities and households. Detailed information about the study characteristics was published elsewhere (Bijl et al, 1998;de Graaf et al, 2010). NEMESIS included 7076 participants aged 18-64 years (average age at baseline 41.2 years, SD=12.2) and consisted of two follow-up surveys, respectively one (T1) and three (T2) years after the baseline measurement (T0).…”

Section: Samples and Designmentioning

confidence: 99%

“…This version of the CIDI generated DSM-IV diagnoses and contained a screening section with key questions for most mental disorders (de Graaf et al, 2010). Only participants answering positively on a key question were administered the complete disorder section.…”

Section: Diagnostic Instrumentsmentioning

confidence: 99%

Psychotic experiences and incident suicidal ideation and behaviour: Disentangling the longitudinal associations from connected psychopathology

Honings

Drukker

Nierop

et al. 2016

Psychiatry Research

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Psychotic experiences and incident suicidal ideation and behaviour 2 ABSTRACT This study examines the longitudinal associations between psychotic experiences (PE) and incident suicidal ideation and behaviour in the general population, and to what degree the association may be confounded by nonpsychotic psychopathology. Data from three prospective, general population cohorts were combined into one dataset (n=15837) and analysed using logistic regression, controlling for continuous measures of depression, anxiety and mania symptoms. Analyses were conducted in the entire sample, and in subsamples stratified by presence or absence of mental disorders. The presence of PE at baseline increased the risk of incident suicidal ideation and behaviour. However, adjustment for dimensional measures of psychopathology reduced effect sizes, although PE remained significantly associated with suicide attempts. Further examination of the associations revealed that PE were only associated with suicide attempts in individuals with at least one mental disorder.Similarly, in individuals without mental disorders, the risk of suicidal ideation increased as PE co-occurred with more symptom domains. The results of this study confirm that individuals with PE are at increased risk of suicidal ideation and behaviour. However, these associations are not specific, but reflect the increased risk of suicidal ideation in individuals with subthreshold multidimensional psychopathology and suicide attempts in individuals with co-occurring mental disorders.

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“…Data on the general population were derived from a Dutch representative psychiatric-epidemiological general population survey, NEMESIS-2 (Netherlands Mental Health Survey and Incidence Study-2) [38,40]. Through a multi-stage, stratified random sampling procedure, 6646 participants between the ages of 18 and 64 years were recruited between November 2007 and July 2009.…”

Section: Subjectsmentioning

confidence: 99%

Mental health differences between frequent cannabis users with and without dependence and the general population

et al. 2013

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Mental health differences between frequent cannabis users with and without dependence and the general population van der Pol, P.; Liebregts, N.; de Graaf, R.; ten Have, M.; Korf, D.J.; van den Brink, W.; van Laar, M. Published in: Addiction DOI:10.1111/add.12196 Link to publicationCitation for published version (APA): van der Pol, P., Liebregts, N., de Graaf, R., ten Have, M., Korf, D. J., van den Brink, W., & van Laar, M. (2013). Mental health differences between frequent cannabis users with and without dependence and the general population. Addiction, 108(8), 1459-1469. DOI: 10.1111/add.12196 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. ABSTRACTAims To compare the prevalence of mental disorders between frequent cannabis users with and without dependence and the general population. Design Cross-sectional comparison of interview data. Setting Enriched community sample of frequent cannabis users and a representative sample of non-users and non-frequent users from the general population. Participants A total of 521 young adult (aged 18-30 years) frequent cannabis users, 252 of whom were with DSM-IV cannabis dependence (D+) and 269 without DSM-IV cannabis dependence (D-), and 1072 young adults from the general population. Measurements Multinomial logistic regression was used to compare groups regarding the presence of DSM-IV mental disorders. Detailed measures of cannabis use, childhood adversity and other substance use were considered confounders. Findings Compared with the general population, externalizing disorders were more prevalent in D-[odds ratio (OR) = 8.91, P < 0.001] and most prevalent in D+ (OR = 17.75, P < 0.001), but internalizing disorders were associated only with D+ (mood OR = 4.15, P < 0.001; anxiety OR = 2.20, P = 0.002). Associations were attenuated (and often became non-significant) after correction for childhood adversity and substance use other than cannabis. However, the prevalence of mental disorders remained higher in D+ compared with D-(OR = 2.40, P < 0.001), although cannabis use patterns were remarkably similar. Conclusions Cannabis use patterns, childhood adversity and the use of other substances are similar in dependent and non-dependent frequent cannabis users. With the exception of more externalizing disorders, the mental health ...

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The Netherlands Mental Health Survey and Incidence Study‐2 (NEMESIS‐2): design and methods

Cited by 189 publications

References 79 publications

Functioning before and after a major depressive episode: pre-existing vulnerability or scar? A prospective three-wave population-based study

Functioning before and after a major depressive episode: pre-existing vulnerability or scar? A prospective three-wave population-based study

Psychotic experiences and incident suicidal ideation and behaviour: Disentangling the longitudinal associations from connected psychopathology

Mental health differences between frequent cannabis users with and without dependence and the general population

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