The Nerves of Bone

Sherman, Mary S.

doi:10.2106/00004623-196345030-00010

Cited by 83 publications

(33 citation statements)

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“…The nerves of osteones (Haversian systems) have been suggested to function in the control of bone blood flow, transmission of sensation from the skeleton or in a trophic manner [Harrell, 1937;Sherman, 1963;Retzlaff et al, 1981;Thurston, 1982], In the present study, the reduced uptake of 'H-proline by osteoblasts and the observed reduction in the synthesis and release of bone matrix components following denervation may repre sent the loss of a neurotrophic influence in the regula tion of osteogenesis [Milgram and Robinson, 1965;Chiego and Singh, 1981;Singh et al. 1981].…”

Section: Discussionmentioning

confidence: 99%

Effect of Guanethidine-Induced Sympathectomy on Osteoblastic Activity in the Rat Femur Evaluated by <sup>3</sup>H·Proline Autoradiography

Herskovits¹,

Singh²

1984

Cells Tissues Organs

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Osteoblastic activity in the rat femur was assessed following sympathectomy by injections of guanethidine sulfate from birth to 14 days of age. At ages 30, 45 and 90 days, osteogenesis was monitored by quantitative autoradiography using ³H-proline. Grain counts over periosteal osteoblasts of the femoral diaphysis showed a significant reduction in the uptake of ³H -proline in sympathectomized rats. The results indicate that the sympathetic innervation of bone influences osteoblastic activity and provide support for a role of the autonomic nervous system in the regulation of bone formation.

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Section: Discussionmentioning

confidence: 99%

Effect of Guanethidine-Induced Sympathectomy on Osteoblastic Activity in the Rat Femur Evaluated by <sup>3</sup>H·Proline Autoradiography

Herskovits¹,

Singh²

1984

Cells Tissues Organs

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“…It is often difficult to determine whether the tumor truly originates from bone or arises from the nerve roots and bone is secondarily involved (14). Intraosseous nerves are typically associated with arterial vessels in the nutrient canal and participate in vasomotor functions, and the majority appear to be non-myelinated (15). Therefore, an intraosseous schwannoma involving a long bone may be associated with the second mechanism, the tumor arises and develops within the nutrient canal, and related to the site of the nutrient artery; however, the most common location of intraosseous schwannomas in long bones remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Association between intraosseous schwannoma occurrence and the position of the intraosseous nutrient vessel: A case report

et al. 2016

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Abstract. Intraosseous schwannoma is a rare benign bone tumor that originates from Schwann cells of the nerve sheath. The majority of intraosseous schwannomas arise in the mandible and sacrum, but an intraosseous schwannoma involving the ulna is described in the present case report. Radiologically, the current case presented as a well-defined lytic lesion, with a pathological fracture and no intralesional calcification, in the proximal metaphysis of the left ulna. Using magnetic resonance imaging, an intraosseous mass spreading out from the cortical defect was observed. The lesion appeared isointense to skeletal muscle on T1-weighted images, and hyperintense or heterogeneous on T2-weighted images. The differential diagnosis comprised benign bone tumors, including bone cyst, aneurysmal bone cyst, giant cell tumor and fibrous dysplasia. Based on the results of a needle biopsy, a schwannoma involving the ulnar bone was diagnosed, and tumor marginal resection followed by artificial bone grafting and fixation was performed. A total of one year subsequent to surgery, the patient exhibits no symptoms, and there is no evidence of disease recurrence.

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“…True ''intraosseous schwannoma'' has been defined as an intraosseous tumor with or without extraosseous components and no neural tissue involvement with the tumor [2]. The infrequent occurrence of intraosseous schwannomas has been attributed to a paucity of sensory fibers in the bones although the presence of myelinated fibers within the marrow of the vertebral bodies has been reported [13].…”

Section: Discussionmentioning

confidence: 99%

Intraosseous schwannoma originating from the posterior column of the thoracic spine

et al. 2010

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Only eight cases of intraosseous schwannoma of the mobile spine have been reported in the English literature. We report herein a rare case of intraosseous schwannoma mimicking benign osteoblastoma originating from the posterior column of the thoracic spine. A 60-yearold man presented with a history of back pain for several months. The patient subsequently developed gait disturbance and numbness on bilateral lower limbs. Preoperative computed tomography and magnetic resonance imaging showed a neoplastic lesion occupying the posterior column of the ninth thoracic vertebra. The most likely preoperative diagnosis was osteoblastoma. The patient underwent tumor excision and posterior fusion with instrumentation. No nerve involvement of the tumor was identified intraoperatively. Histological diagnosis was schwannoma. To the best of our knowledge, this represents the first report of intraosseous schwannoma originating from the posterior column of the mobile spine.

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The Nerves of Bone

Cited by 83 publications

References 0 publications

Effect of Guanethidine-Induced Sympathectomy on Osteoblastic Activity in the Rat Femur Evaluated by <sup>3</sup>H·Proline Autoradiography

Effect of Guanethidine-Induced Sympathectomy on Osteoblastic Activity in the Rat Femur Evaluated by <sup>3</sup>H·Proline Autoradiography

Association between intraosseous schwannoma occurrence and the position of the intraosseous nutrient vessel: A case report

Intraosseous schwannoma originating from the posterior column of the thoracic spine

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