The Nerve Fiber Layer in the Diagnosis of Glaucoma

Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography

“…Various reports have shown that with advancing age, the RNFL thickness decreases (Costello et al, 2008;Sommer et al, 1977). Similar findings were also seen in our study.…”

“…The RNFL thickness was further analyzed in different quadrants for comparison among the three groups of refractive error which revealed a statistically significant difference only in the nasal quadrant (p < 0.05) (Table 5) Discussion Optic nerve head evaluation as well as RNFL assessment are important diagnostic tools for the early detection and management of glaucoma. Studies have shown that RNFL damage occurs in glaucoma (Bowd et al, 2000;Sommer et al, 1977;Sony et al, 2004;Quigley et al, 1980). RNFL thinning is also seen in myopia (Budenz et al, 2007;Hougaard et al, 2006) and in old age (Lee et al, 2000;Sony et al, 2004).…”

Quantitative Analysis of Retinal Nerve Fiber Layer Thickness of Normal Children and Adolescents

“…[1][2][3][4] The optic disc examination using ophthalmoscope varies widely depending on the examiner, and since in normal eyes the individual variation of the optic disc shape is large, this examination, although it suitable as a glaucoma screening test, cannot contribute decisively to the early and definite diagnosis of glaucoma. 5 It has been shown that changes of the optic disc or in the vicinity of the disc and RNFL defects precede the visual acuity impairment.…”

Characteristics of patients with a localized retinal nerve fiber layer defect and normal optic disc appearance

“…2,3 Some ophthalmologists believe that localized RNFL defects are one of the most sensitive parameters in the detection of glaucoma. 4 However, glaucoma is defined as progressive optic neuropathy, which is characterized by the loss of retinal ganglion cells through disruptions of axoplasmic flow in the lamina cribrosa.…”