The Nephrotic Syndrome in the Elderly: Epidemiological Data

Twenty-four-Year Trends in Incidence and Mortality of Nephrotic Syndrome: A Population-Based Cohort Study

“…Although we did not restrict our analyses to patients with kidney biopsies, we found only slightly higher incidence of nephrotic syndrome (3.85 per 100,000 person–years) than the previously reported annual incidences ranging from 0.58 to 4.2 per 100,000 adults in Europe and Australia. 12–21 The variation in nephrotic syndrome incidences may at least to some extent be explained by the variation in biopsy rates across countries, with, for example, 22-fold more biopsies in Finland than in Romania. 45 Importantly most estimates were based on historical data going up to six decades back.…”

“…45 Importantly most estimates were based on historical data going up to six decades back. [12][13][14][15][16]18,19 Moreover, most prior studies were not restricted to first-time nephrotic syndrome patients, [12][13][14][17][18][19] and thus, may have included prevalent patients. Similar to our findings, increases in nephrotic syndrome incidence with increasing age have previously been reported in France and Italy, but those studies were based on patients with biopsies and included a few elderly patients.…”

“…Similar to our findings, increases in nephrotic syndrome incidence with increasing age have previously been reported in France and Italy, but those studies were based on patients with biopsies and included a few elderly patients. 14,16 A French study reported a small increase in nephrotic syndrome incidence over time from 3.6 per 100,000 person-years in 1976-1980, to 4.0 per 100,000 person-years in 1986-1990, but no updated figures have been reported. 15 Previous studies of mortality in patients with nephrotic syndrome are limited to patients with kidney biopsies.…”

“…10,11 While not all patients with nephrotic syndrome have a kidney biopsy, previous studies on the incidence and mortality of nephrotic syndrome have focused on patients with Submitted August 20, 2021; accepted November 28, 2022 a kidney biopsies. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] These studies report the incidence of adult nephrotic syndrome between 0.58 and 4.2 per 100,000 personyears, [12][13][14][15][16][17][18][19][20][21] , and overall mortality of 6-21% during up to 5 years of follow-up after nephrotic syndrome. [21][22][23] Additionally, several studies have examined the mortality of nephrotic syndrome in subgroups of patients with specific types of glomerulopathy.…”