The nephrotic syndrome in the elderly: clinico-pathological correlations in 317 patients

Johnston, Paul A.; Brown, June; Davison, A. M.

doi:10.1007/bf00451670

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…The distribution of histologic appearance found in our study is similar to previous reports [5,6,7,13,14,17,18,19] in that membranous nephropathy and minimal change disease were frequently diagnosed. The incidence of malignancy is also consistent with other reports [14,20]. In this study, 5.1% of patients were found to have malignant diseases.…”

Section: Discussionsupporting

confidence: 82%

“…In this study, 5.1% of patients were found to have malignant diseases. In a large study of 317 elderly nephrotic patients, only 4.7% had malignant disease, and the incidence was no higher than that in the elderly population as a whole [20]. Although a higher incidence has been noted in another report [19], it is known that about 5% of elderly patients with NS will already have a malignancy or develop one within 1 year of diagnosis [14].…”

Section: Discussionmentioning

confidence: 99%

“…There are previous reports describing the findings of renal biopsy in the elderly [2,3,4,5,6,7,8,13,14,15,16,17,18,19,20], but a direct comparison of clinical outcomes between biopsied and nonbiopsied patients has not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Impact of Renal Biopsy on Outcomes in Elderly Patients with Nephrotic Syndrome

Yoon¹,

Shin²,

Kim³

et al. 2010

Nephron Clin Pract

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Background/Aims: The number of elderly patients with nephrotic syndrome (NS) is increasing. This study aimed to assess the implications of renal biopsy on the outcomes in elderly patients with NS. Methods: Ninety-nine patients diagnosed with NS who were over 60 years of age were reviewed. Secondary NS related to diabetes was excluded. Histopathological diagnosis, comparison of outcomes between the biopsied group (n = 64) and the nonbiopsied group (n = 35) and factors affecting renal survival were evaluated. Results: The biopsied group was significantly younger and had better renal function than the nonbiopsied group. More patients in the biopsied group than in the nonbiopsied group received immunosuppressive treatment (76.6 vs. 42.9%, p < 0.005), and achieved complete remission (45.3 vs. 26.5%, p = 0.013). The complication rates and renal survival rates were not different between the two groups, but the patient survival rates were significantly higher in the biopsied group (p < 0.005). Predictors for renal survival were renal function at diagnosis and response to treatment. Conclusion: Renal biopsy is essential for a correct diagnosis and directed therapeutic approach in elderly patients with NS and may improve the clinical outcomes of these patients.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Clinical Impact of Renal Biopsy on Outcomes in Elderly Patients with Nephrotic Syndrome

Yoon¹,

Shin²,

Kim³

et al. 2010

Nephron Clin Pract

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“…In 259 patients with renal amyloidosis, the Italian Registry of Renal Biopsies reported a frequency of 80% of nephrotic syndrome, with 61% showing normal renal function (Figure 2). This nephrotic syndrome is the presenting symptom in the elderly and a clinical report from the United Kingdom MRC Glomerulonephritis Registry described how in a large group of patients aged >60 years and presenting a nephrotic syndrome, renal amyloidosis occurred in 10.7% of the cases [4]. Amyloidosis was the first cause of secondary nephrotic syndrome in these patients.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Clinical and therapeutic aspects of renal amyloidosis

Schena

Pannarale

Carbonara

1996

Nephrology Dialysis Transplantation

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Abstract. Renal amyloidosis is not a frequent disease: its annual frequency is ~2.5-2.8% of all renal biopsies. Individual cases are normally rare and for this reason clinical findings and therapeutic results obtained by clinical multicentre studies are well considered. This review describes the clinical and therapeutic aspects of renal amyloidosis and refers particularly to the results obtained by the Italian Study Group for renal amyloidosis and by the multicentre Italian study protocol for AL amyloidosis.

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“…Although some geographical differences exist, the most common disease responsible for nephrotic syndrome in adults is membranous nephropathy (1,7,8,13,14). However, minimal change disease, focal segmental glomerulosclerosis and amyloidosis are frequent in patients older than 60 (1,7,8,13,14).…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 99%

Renal Biopsy in Patients Aged 65 Years and Older: A Clinicopathological Analysis

Oğuz¹,

Dede²,

Ay³

et al. 2010

Turk Neph Dial Transpl

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aım: Elderly patients with renal disease have recently attracted increased attention. There has also been an increase in renal biopsies in these patients. The aim of this study was to investigate the influence of the renal biopsy on the diagnosis, management and prognosis of renal diseases in the elderly. maTERıal and mETHOdS:We retrospectively reviewed the clinical files of 632 patients who had undergone renal biopsy in the department of Nephrology, Gulhane School of Medicine between 2000 and 2007. Thirty of these patients included in the present study were 65 or more years old.

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The nephrotic syndrome in the elderly: clinico-pathological correlations in 317 patients

Cited by 12 publications

References 22 publications

Clinical Impact of Renal Biopsy on Outcomes in Elderly Patients with Nephrotic Syndrome

Clinical Impact of Renal Biopsy on Outcomes in Elderly Patients with Nephrotic Syndrome

Clinical and therapeutic aspects of renal amyloidosis

Renal Biopsy in Patients Aged 65 Years and Older: A Clinicopathological Analysis

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