The Nephrotic Syndrome

Squire, J. R.; Blainey, J. D.; Hardwicke, J.

doi:10.1093/oxfordjournals.bmb.a069570

Cited by 57 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It therefore escaped attention that the actual presence of hypovolemia was supported by only few studies. Squire [104] stated that total BV was nearly always reduced by ±25% , but added that more documentation was needed. In children with the NS, a 10% decrease was reported [81].…”

Section: Results Of Pv and Bv Determination In Patients With The Nsmentioning

confidence: 99%

Blood Volume and Sodium Retention in the Nephrotic Syndrome: A Controversial Pathophysiological Concept

Mees

Geers

Koomans³

1984

Nephron

View full text Add to dashboard Cite

Section: Results Of Pv and Bv Determination In Patients With The Nsmentioning

confidence: 99%

Blood Volume and Sodium Retention in the Nephrotic Syndrome: A Controversial Pathophysiological Concept

Mees

Geers

Koomans³

1984

Nephron

View full text Add to dashboard Cite

“…Obviously if the patient is grossly edematous, then 5%o of the body weight will give an erroneous plasma volume. Also in the nephrotic, the plasma volume tends to be less than normal (23). In such edematous states, the use of albumin-'I to measure plasma volume also leads to erroneous results, since the volume of distribution of labeled albumin is greater than that of plasma (13).…”

Section: Methodsmentioning

confidence: 99%

Studies on the turnover of triglyceride and esterified cholesterol in subjects with the nephrotic syndrome

McKenzie¹,

Nestel²

1968

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T RA CT Factors involved in the hyperlipidemia of nephrosis have been studied in seven patients. The turnover of triglyceride was measured in plasma very low density lipoproteins after the injection of glycerol-'4C. The turnover of esterified cholesterol was measured in whole plasma and in very low density lipoproteins after the injection of mevalonic acid-2-3H.Urine protein loss was found to be significantly correlated with the plasma concentrations of triglyceride and free cholesterol, suggesting that increasing loss of protein is associated with the formation of larger lipoproteins. Lactescent plasmas were found in the subjects with the greatest protein loss.The turnover rate of triglyceride tended to be higher among subjects with higher than with lower triglyceride concentrations and was on the average higher than among six normotriglyceridemic subjects. However, there was also evidence for decreased clearance of glyceride from plasma. The hypertriglyceridemia of nephrosis appeared to reflect both increased formation of glyceride and decreased removal of glyceride from plasma.The turnover of esterified cholesterol was significantly higher in whole plasma of nephrotic subjects than in normocholesterolemic nonnephrotic patients. Esterified cholesterol turnover in very Send reprint requests to Dr. P. J. Nestel,

show abstract

“…At this time the pathophysiology of kwashiorkor and of nephrotic syndrome were thought to be the same. In the literature on nephrotic syndrome doubts were expressed because of the frequent, unexpected and spontaneous resolution of the oedema following a fever with no change in plasma proteins 14 and the long-lived response to plasma infusion despite the plasma albumin returning to pretreatment level within days 15 . Williams 16 ascribed kwashiorkor to weaning to a maize based diet and showed that they responded to a high protein diet of milk and marmite.…”

mentioning

confidence: 99%

“…The first serious attack on the protein deficiency hypothesis came from Gopalan 15 , who examined the diets of village children in India. He could find no antecedent dietary difference between those who developed marasmus and those who developed kwashiorkor.…”

mentioning

confidence: 99%

Oedematous malnutrition

Golden

1998

British Medical Bulletin

View full text Add to dashboard Cite

Oedematous malnutrition in the child or adult is not caused by protein deficiency; such a concept can lead to fatal therapeutic error in oedematous malnutrition treatment. On the other hand, deficiency of protein, or the other type II nutrients, is common and causes stunting and wasting. In kwashiorkor, the deficiency is more likely to be due to one or several type I nutrients, particularly those involved with anti-oxidant protection.

show abstract

The Nephrotic Syndrome

Cited by 57 publications

References 0 publications

Blood Volume and Sodium Retention in the Nephrotic Syndrome: A Controversial Pathophysiological Concept

Blood Volume and Sodium Retention in the Nephrotic Syndrome: A Controversial Pathophysiological Concept

Studies on the turnover of triglyceride and esterified cholesterol in subjects with the nephrotic syndrome

Oedematous malnutrition

Contact Info

Product

Resources

About