The neonatal intestinal resistome and factors that influence it—a systematic review

Leo, Stefano; Curtis, Nigel; Zimmermann, Petra

doi:10.1016/j.cmi.2022.07.014

Cited by 5 publications

(4 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Factors correlated with an increased ARG prevalence include antibiotic use during childbirth and in the neonatal period [ 78 ]. Conversely, breastfeeding and the administration of probiotics to neonates are linked with a reduced presence of ARGs [ 79 ]. The meta-analysis by Grech et al [ 80 ] demonstrated that maternal exposure to antibiotics during childbirth was associated with a modest reduction in alpha diversity in their newborns as compared to that in the control group, who were not exposed to antibiotics.…”

Section: Impact Of Maternal Microbiota On Foetal Immune System Develo...mentioning

confidence: 99%

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

Adamczak,

Werblińska,

Jamka

et al. 2024

Biomedicines

View full text Add to dashboard Cite

In recent years, the number of scientific publications on the role of intestinal microbiota in shaping human health, as well as the occurrence of intestinal dysbiosis in various disease entities, has increased dynamically. However, there is a gap in comprehensively understanding the factors influencing a child’s gut microbiota. This review discusses the establishment of gut microbiota and the immunological mechanisms regulating children’s microbiota, emphasising the importance of prioritising the development of appropriate gut microbiota in a child from the planning stages of pregnancy. The databases PubMed, Web of Sciences, Cochrane, Scopus and Google Scholar were searched to identify relevant articles. A child’s gut microbiota composition is influenced by numerous factors, such as diet during pregnancy, antibiotic therapy, the mother’s vaginal microbiota, delivery method, and, later, feeding method and environmental factors. During pregnancy, the foetus naturally acquires bacterial strains from the mother through the placenta, thereby shaping the newborn’s immune system. Inappropriate maternal vaginal microbiota may increase the risk of preterm birth. Formula-fed infants typically exhibit a more diverse microbiota than their breastfed counterparts. These factors, among others, shape the maturation of the child’s immune system, impacting the production of IgA antibodies that are central to cellular humoral immune defence. Further research should focus on identifying specific microbiota–immune system interactions influencing a child’s immune health and developing personalised treatment strategies for immune-related disorders.

show abstract

Section: Impact Of Maternal Microbiota On Foetal Immune System Develo...mentioning

confidence: 99%

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

Adamczak,

Werblińska,

Jamka

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…A recent systematic review on the neonatal intestinal resistome [ 39 ] observed a higher presence of ARGs in newborns when compared to their mothers’ microbiota. Gene transfer from mother to child occurs, considering that even newborns who have not been exposed to antibiotics harbor a considerable load of ARGs.…”

Section: The Infant Intestinal Resistomementioning

confidence: 99%

Old Folks, Bad Boon: Antimicrobial Resistance in the Infant Gut Microbiome

et al. 2023

View full text Add to dashboard Cite

The development of the intestinal microbiome in the neonate starts, mainly, at birth, when the infant receives its founding microbial inoculum from the mother. This microbiome contains genes conferring resistance to antibiotics since these are found in some of the microorganisms present in the intestine. Similarly to microbiota composition, the possession of antibiotic resistance genes is affected by different perinatal factors. Moreover, antibiotics are the most used drugs in early life, and the use of antibiotics in pediatrics covers a wide variety of possibilities and treatment options. The disruption in the early microbiota caused by antibiotics may be of great relevance, not just because it may limit colonization by beneficial microorganisms and increase that of potential pathogens, but also because it may increase the levels of antibiotic resistance genes. The increase in antibiotic-resistant microorganisms is one of the major public health threats that humanity has to face and, therefore, understanding the factors that determine the development of the resistome in early life is of relevance. Recent advancements in sequencing technologies have enabled the study of the microbiota and the resistome at unprecedent levels. These aspects are discussed in this review as well as some potential interventions aimed at reducing the possession of resistance genes.

show abstract

“…These bacteria are a major reservoir of clinically relevant ARGs (5)(6)(7). Antibiotics influence the composition of intestinal microbiome and resistome (8) but ARGs can also be detected in the absence of antibiotic treatment (9,10).…”

Section: Introductionmentioning

confidence: 99%

“…PERMANOVA, permutational multivariate analysis of variance; ARGs, antibiotic resistance genes.Pseudo-F statistics are used in PERMANOVA to compare within-group to between-group variance(24).receive formula milk during the first week of life (median of total normalised ARG counts 665, IQR: 422-1,026, vs. 575, IQR: 346-1,009, p-value 0.3).…”

mentioning

confidence: 99%

Metagenomics analysis of the neonatal intestinal resistome

et al. 2023

Self Cite

View full text Add to dashboard Cite

IntroductionThe intestinal microbiome forms a major reservoir for antibiotic resistance genes (ARGs). Little is known about the neonatal intestinal resistome.ObjectiveThe objective of this study was to investigate the intestinal resistome and factors that influence the abundance of ARGs in a large cohort of neonates.MethodsShotgun metagenomics was used to analyse the resistome in stool samples collected at 1 week of age from 390 healthy, term-born neonates who did not receive antibiotics.ResultsOverall, 913 ARGs belonging to 27 classes were identified. The most abundant ARGs were those conferring resistance to tetracyclines, quaternary ammonium compounds, and macrolide-lincosamide-streptogramin-B. Phylogenetic composition was strongly associated with the resistome composition. Other factors that were associated with the abundance of ARGs were delivery mode, gestational age, birth weight, feeding method, and antibiotics in the last trimester of pregnancy. Sex, ethnicity, probiotic use during pregnancy, and intrapartum antibiotics had little effect on the abundance of ARGs.ConclusionEven in the absence of direct antibiotic exposure, the neonatal intestine harbours a high abundance and a variety of ARGs.

show abstract

The neonatal intestinal resistome and factors that influence it—a systematic review

Cited by 5 publications

References 62 publications

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

Maternal-Foetal/Infant Interactions—Gut Microbiota and Immune Health

Old Folks, Bad Boon: Antimicrobial Resistance in the Infant Gut Microbiome

Metagenomics analysis of the neonatal intestinal resistome

Contact Info

Product

Resources

About