The Negro River (Ancash-Peru): A unique case of water pollution, three environmental scenarios and an unresolved issue

Grande, J. A.; Loayza‐Muro, Raúl; Alonso-Chaves, Francisco M.; Garrido, Juan Carlos Fortes; Willems, B. A.; Sarmiento, Aguasanta Miguel; Santistebán, M.; Dávila, José Miguel; Torre, M. L. de la; Durães, Nuno; Díaz-Curiel, Jesús; Luís, Ana Teresa

doi:10.1016/j.scitotenv.2018.08.068

Cited by 20 publications

(14 citation statements)

References 35 publications

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“…Mine wastewater is continuously monitored and treated prior to release from the site: cause–effect relationships between the geological setting and mining activities versus water quality in the downstream catchment area are topic of ongoing study. 67…”

Section: Methodsmentioning

confidence: 99%

“…Waste rock at Antamina is processed based on a reactivity classification scheme that accounts for sulfide and metal content, among others, and stored on-site in different waste-rock storage facilities that drain into an isolated tailings facility. Mine wastewater is continuously monitored and treated prior to release from the site: cause–effect relationships between the geological setting and mining activities versus water quality in the downstream catchment area are topic of ongoing study …”

Section: Methodsmentioning

confidence: 99%

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Mobilization of Metal(oid) Oxyanions through Circumneutral Mine Waste-Rock Drainage

et al. 2019

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Most studies on the weathering of mine waste rock focus on the generation of acidic drainage with high metal concentrations, whereas metal(loid) release under neutral-rock drainage (NRD) conditions has received limited attention. Here, we present geochemical and mineralogical data from a long-term (>10 years) kinetic testing program with 50 waste-rock field barrels at the polymetallic Antamina mine in Peru. The weathering of most rock lithologies in the field experiments generated circumneutral to alkaline drainage (6 < pH < 9) but with concentrations of the oxyanion-forming metal(loid)s As, Mo, Se, and Sb in the mg/L range. The mobilization of As and Sb was particularly efficient from intrusive, marble and hornfels rocks that contained labile As- and Sb-sulfides, irrespective of bulk elemental content or waste-rock reactivity. High-alkalinity drainage from these materials sustained neutral-pH conditions that are unfavorable to oxyanion adsorption onto Fe-(oxyhydr)oxides and, therefore, enhanced As and Sb leaching. The release of Mo and Se from sulfidic skarn and intrusive waste rock was more proportional to elemental content but equally enhanced by pH-inhibited adsorption and negligible secondary mineral precipitation under NRD conditions. Our results demonstrate that oxyanion concentrations of environmental concern may be conveyed by neutral- to alkaline-pH waste-rock drainage and should be a focus of mine wastewater monitoring programs.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Mobilization of Metal(oid) Oxyanions through Circumneutral Mine Waste-Rock Drainage

et al. 2019

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“…Finally, we must highlight the possible role of the environment in the hepatocarcinogenic process due to the high mineral content of the subsoil and rivers. This statement was endorsed by several studies showing the presence of high heavy metal concentrations in the Andean regions of Peru 44 – 46 . In Egypt, Elwakil et al .…”

Section: Discussionmentioning

confidence: 91%

Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells

Cano

Bertani

Island

et al. 2021

Sci Rep

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We have previously described a form of hepatocellular carcinoma (HCC) in non-cirrhotic liver (HCC-NC) developed by Peruvian patients. We analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting HCC-NC. Clinical, histopathological data, and HCC and non-tumoral liver (NTL) samples of 38 Peruvian and 38 French HCC-NC patients, were studied. Twelve metals were quantified using ICP/MS: Mn, Fe, Cu, Co, Zn, As, Se, Rb, Mo, Cd, Pb, and Sn. Associations between metals and survival were assessed. Our data showed significant differences between cohorts. Mean ages were 40.6 ± 20, 67.5 ± 9 years old for Peruvians and French, respectively. Fifty percent of the Peruvian patients were positive for the HBsAg, versus 3% in French patients. Mn, Cu, Zn, As, Se, Rb, Mo, Cd, Sn metal concentrations were higher in NTL of Peruvians. Importantly, metal concentrations were lower in HCC areas compared to NTL tissues in both cohorts, except for Cu for which mean concentration was higher in HCC (p < 0.05). Se concentration in HCC was associated with extended survival only in Peruvians. Our data, obtained in Peruvian and French HCC-NC cohorts, highlights similarity in the metallomic profile of HCC compared to NTL during the hepatic tumorigenesis in these specific groups of patients.

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“…This statment was endorsed by several studies showing the presence of high heavy metal concentrations in the Andean regions of Peru. [41][42][43] In Egypt, Elwakil et al have also described high concentrations of Cd, Pb, As, and Hg in blood samples from HCC patients who were exposed to the consumption of contaminated plants. 44 Therefore, we cannot rule out the relationship between the presence of metal in environment and natural history HCC.…”

Section: Discussionmentioning

confidence: 99%

Metallomic Profile in Non-cirrhotic Hepatocellular Carcinoma Supports a Phenomenon of Metal Metabolism Adaptation in Tumor Cells

Cano

Bertani

Island

et al. 2020

Preprint

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Our group has previously described a particular form of Hepatocellular carcinoma (HCC) developed in non-cirrhotic liver (HCC-NC) developed in Peruvian patients Our aim is to analyze the HCC-NC from clinical-biological findings in two different cohorts (Peruvian and French) and the link with metallomic profile. Clinical, histopathological and also tumoral (T) and non-tumoral liver (NTL) samples of 38 Peruvian and 45 French patients were studied. Twelve metals were assayed using ICP/MS: Mn, Fe, Cu, Co, Zn, As, Se, Rb, Mo, Cd, Pb, and Sn. Possible associations between metals and survival were also evaluated. Overall, results show clearly differences between both cohorts. Mean age were 41 ± 20 and 68 ± 9 years-old for Peruvians and French, respectively. 80% of Peruvian patients were positive for the HBsAg, versus 9% in French patients. Metals concentrations were higher in the NTL of Peruvians (p < 0.05) compared to the French. In both cohort metal concentrations were lower in HCC areas compared to NTL, excepted for Cu for which mean concentration was increased in HCC (p < 0.05). Se concentration in HCC was associated with better survival only in Peruvians. Our data shows, in both HCC-NC cohorts, that the process of hepatic tumorigenesis impact similarity the metallomic profile in tumor.

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The Negro River (Ancash-Peru): A unique case of water pollution, three environmental scenarios and an unresolved issue

Cited by 20 publications

References 35 publications

Mobilization of Metal(oid) Oxyanions through Circumneutral Mine Waste-Rock Drainage

Mobilization of Metal(oid) Oxyanions through Circumneutral Mine Waste-Rock Drainage

Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells

Metallomic Profile in Non-cirrhotic Hepatocellular Carcinoma Supports a Phenomenon of Metal Metabolism Adaptation in Tumor Cells

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