The negative regulatory role of ORMDL3 in antigen-induced cytokine production, cyclooxygenase-2 expression, and chemotactic response in mast cells (IRM11P.637)
Abstract:Single-nucleotide polymorphism studies have linked the chromosome 17q12-q21 region, where human ORMDL3 gene is localized, to the risk of asthma and other inflammatory diseases. Although mast cells are involved in development of these diseases, the contribution of ORMDL3 to mast cell physiology is unknown. In this study we examined the role of ORMDL3 in mouse bone marrow-derived mast cells with reduced or enhanced ORMDL3 expression. Our data show that in antigen-activated mast cells, reduced expression of the O… Show more
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