The need of a correct experimental model in microsurgery: An issue that may invalidate the resultsis. It time for an international scientific “Bank”?

Amodeo, Chiara Andretto

doi:10.1002/micr.30071

Cited by 1 publication

(1 citation statement)

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“…This landmark is a critical structure whose manipulations may compromise seriously the posterior limb's blood flow, unlike the femoral artery. The complete occlusion of this last vessel preserves the flow thanks to an extra-abdominal anastomotic circle between the internal and external iliac arteries ( 6 , 50 ).…”

Section: Experimental In Vivo Aneurysm Developmentmentioning

confidence: 99%

Beyond Classic Anastomoses Training Models: Overview of Aneurysm Creation in Rodent Vessel Model

et al. 2022

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Nowadays, due to the decline in the number of microsurgical clippings for cerebral aneurysms and revascularization procedures, young neurosurgeons have fewer opportunities to participate and train on this type of surgery. Vascular neurosurgery is a demanding subspecialty that requires skills that can only be acquired with technical experience. This background pushes the new generations to be ready for such challenging cases by training hard on different available models, such as synthetic tubes, chicken wings, or placenta vessels. Although many training models for vascular neurosurgery have been described worldwide, one of the best is the rodent vessels model. It offers pulsation, coagulation, and real blood flow conditions in a physiologic atmosphere that mimics perfectly the intracranial human vessels environment, especially in terms of size. However, the current differences in governmental different regulations about the use of living animals in medical experimentation and the social awareness, as well as the lack of financial support, cause more difficulties for neurosurgeons to start with that kind of training. In this review, we describe the tools and techniques as basic steps for vascular microsurgery training by using rodent models, that provide an accurate copy of brain vessels environment under stable conditions. The initial three classical known microanastomoses for neurosurgeons are end-to-end, end-to-side, and side-to-side, but in literature, there have been described other more complex exercises for training and investigation, such as aneurysm models. Although there is still little data available, we aim to summarize and discuss aneurysm's training models and reviewed the current literature on the subject and its applications, including a detailed description of the techniques.

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Section: Experimental In Vivo Aneurysm Developmentmentioning

confidence: 99%