The need for precision nutrition, genetic variation and resolution in Covid-19 patients

Simopoulos, Artemis P.; Serhan, Charles N.; Bazinet, Richard P.

doi:10.1016/j.mam.2021.100943

Cited by 24 publications

(19 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants were asked to report the number of pieces/tablespoons/cups of each item they consumed or to choose one of several pre-specified frequency categories. Among these choices, baseline servings of vegetables (cooked, raw), fruit (fresh, dried), oily fish, pro-cessed meat, red meat (beef, lamb/mutton, or pork), tea, and coffee have specifically been identified as contributing nutritional factors implicated in immunity [19][20][21][22][23][24] and were thus targeted for consideration in this study. The details of the questions and possible answers for these diet factors are provided in Supplemental Table S1.…”

Section: Baseline Dietary Datamentioning

confidence: 99%

Dietary Behaviors and Incident COVID-19 in the UK Biobank

Rydland

Achenbach

et al. 2021

Nutrients

View full text Add to dashboard Cite

Background: Nutritional status influences immunity but its specific association with susceptibility to COVID-19 remains unclear. We examined the association of specific dietary data and incident COVID-19 in the UK Biobank (UKB). Methods: We considered UKB participants in England with self-reported baseline (2006–2010) data and linked them to Public Health England COVID-19 test results—performed on samples from combined nose/throat swabs, using real time polymerase chain reaction (RT-PCR)—between March and November 2020. Baseline diet factors included breastfed as baby and specific consumption of coffee, tea, oily fish, processed meat, red meat, fruit, and vegetables. Individual COVID-19 exposure was estimated using the UK’s average monthly positive case rate per specific geo-populations. Logistic regression estimated the odds of COVID-19 positivity by diet status adjusting for baseline socio-demographic factors, medical history, and other lifestyle factors. Another model was further adjusted for COVID-19 exposure. Results: Eligible UKB participants (n = 37,988) were 40 to 70 years of age at baseline; 17% tested positive for COVID-19 by SAR-CoV-2 PCR. After multivariable adjustment, the odds (95% CI) of COVID-19 positivity was 0.90 (0.83, 0.96) when consuming 2–3 cups of coffee/day (vs. <1 cup/day), 0.88 (0.80, 0.98) when consuming vegetables in the third quartile of servings/day (vs. lowest quartile), 1.14 (1.01, 1.29) when consuming fourth quartile servings of processed meats (vs. lowest quartile), and 0.91 (0.85, 0.98) when having been breastfed (vs. not breastfed). Associations were attenuated when further adjusted for COVID-19 exposure, but patterns of associations remained. Conclusions: In the UK Biobank, consumption of coffee, vegetables, and being breastfed as a baby were favorably associated with incident COVID-19; intake of processed meat was adversely associated. Although these findings warrant independent confirmation, adherence to certain dietary behaviors may be an additional tool to existing COVID-19 protection guidelines to limit the spread of this virus.

show abstract

Section: Baseline Dietary Datamentioning

confidence: 99%

Dietary Behaviors and Incident COVID-19 in the UK Biobank

Rydland

Achenbach

et al. 2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…Linoleic acid, an inflammatory response modulator [ 157 ] isolated from the traditional meal Vicia faba [ 158 ], significantly suppresses MERS-CoV replication [ 159 ]. Toelzer et al hypothesized that the combination of remdesivir and linoleic acid, an essential diunsaturated fatty acid, may be superior for treating COVID-19 patients over remdesivir alone [ 160 ].…”

Section: Natural Products In Combination With the Fda-approved Drugs Inhibit Sars-cov-2mentioning

confidence: 99%

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

View full text Add to dashboard Cite

As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases.

show abstract

“…Nevertheless, 18:3n-3 and 18:2n-6 fatty acids must be obtained through a balanced diet; therefore, both are entitled essential fatty acids (Broughton, Tocher & Betancor, 2020;Zhang et al, 2019;Zhukova, 2019). The 18:3n-3 is present in plants and marine animals, although superior concentration could be found in linseed, chia, and perilla grains; and 18:2n-6 is encountered in vegetable oils, such as sunflower, corn, and soybean oils (Perini et al, 2010;Sargi et al, 2013;Simopoulos, Serhan & Bazinet, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The 18:2n-6 fatty acid is the precursor of the metabolic pathway of the n-6 polyunsaturated fatty acid family, and through it, is possible to synthesize 20:4n-6 fatty acid; the main precursor of eicosanoids production, which in ideal amounts, improves the immune system response and stress resistance (Simopoulos, Serhan & Bazinet, 2021;Pérez et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, at elevated concentrations, it may offer toxic properties to the organism, and promotes competition among enzymes responsible for activating the metabolic pathway of the n-3 polyunsaturated fatty acid family, destabilizing essential fatty acid production, such as 20:5n-3 and 22:6n-3 fatty acids, produced from 18:3n-3 (Simopoulos, Serhan & Bazinet, 2021;Balić et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the fatty acid composition of different parts of zebrafish fed diets incorporated with linseed and sunflower oils

Cruz

Silva

Castro

et al. 2021

RSD

View full text Add to dashboard Cite

This study aimed to evaluate the fatty acid composition of zebrafish fed diets containing linseed oil compared to sunflower oil. First, diets supplemented with linseed and sunflower were formulated, fish were fed for 40 days, and their parts collected for analysis. Diet composition analysis, extraction and derivatization of fatty acids, gas chromatography analysis, RNA extraction and cDNA synthesis, quantitative real-time polymerase chain reaction (qRT-PCR, and statistical analyses were performed. Linseed oil exhibited an omega-3 rich lipid profile. 18:3n-3 content incorporated into the muscle tissue of fish fed linseed oil was 50% higher than that fed sunflower oil. This higher amount of 18:3n-3 favored the production of 20:5n-3 and 22:6n-3 fatty acids by synthetic pathways in the organism since these fatty acids were not initially found in the oil composition. Furthermore, in all analyzed parts of zebrafish that were fed linseed oil, concentration of 20:4n-6 were lower, while 20:5n-3 and 22:6n-3 were higher compared to the same parts fed with sunflower oil. PCR expression assay showed no significant difference, indicating that linseed oil diet was not harmful. Thus, this work evidenced that synthesis of essential fatty acids, primarily omega-3 fatty acids, was greater in zebrafish upon consumption of diets supplemented with linseed oil.

show abstract

The need for precision nutrition, genetic variation and resolution in Covid-19 patients

Cited by 24 publications

References 34 publications

Dietary Behaviors and Incident COVID-19 in the UK Biobank

Dietary Behaviors and Incident COVID-19 in the UK Biobank

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Assessment of the fatty acid composition of different parts of zebrafish fed diets incorporated with linseed and sunflower oils

Contact Info

Product

Resources

About