1978
DOI: 10.1016/s0304-3835(78)80039-1
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The need for a mammalian test system for mutagens: Action of some reducing agents

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Cited by 74 publications
(10 citation statements)
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“…In the studies of Stich et al (1978), MacRae and Stich (1979) as well as in the present one, GSH was applied in Eagle's MEM, whereas 0nfelt and Klasterska (1983,1984) and, probably, Speit et al (1980) used Hank's solution. Our observation that the genotoxic effects of GSH were abolished by application in Hank's may explain the striking discrepancies between the different studies.…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…In the studies of Stich et al (1978), MacRae and Stich (1979) as well as in the present one, GSH was applied in Eagle's MEM, whereas 0nfelt and Klasterska (1983,1984) and, probably, Speit et al (1980) used Hank's solution. Our observation that the genotoxic effects of GSH were abolished by application in Hank's may explain the striking discrepancies between the different studies.…”
Section: Discussionmentioning
confidence: 84%
“…Their genotoxic properties have also been demonstrated. With respect to GSH, Stich et al (1978) reported the induction of unscheduled DNA synthesis and clastogenicity in the presence of Cu 2+ ions in human fibroblasts and CHO cells at 10 -2 or 10 -3 moles/1 GSH, respectively, after a 3 h exposure. At higher concentrations both activities declined.…”
Section: Discussionmentioning
confidence: 99%
“…Stich et al (1978) and MacRae and Stich (1979) reported a "unique dose-response" of thiols (cysteine, cysteamine, GSH) in clastogenicity, unscheduled DNA synthesis and SCE assays in CHO cells with one or two maxima and a decline of genotoxicity at higher concentrations. Recently, we performed a pilot experiment with GSH, the GSH-mimicking drug 2-mercaptopropionylglycine, and cysteine.…”
Section: Thustmentioning
confidence: 99%
“…Thus, oxidative stress appears to be involved in the process of mutagenesis, carcinogenesis, and aging [1]. Evidence has been obtained that free radicals are mutagenic and can induce base changes, single-strand breaks and apurinic/apyrimidinic sites [3][4][5], possibly leading to the onset of chromosome aberrations (CA) [6].…”
Section: Introductionmentioning
confidence: 99%