The necessity of building population specific prediction equations for clinical assessment of pulmonary function tests

Hellmann, Sarah; Goren, Ayana I.

doi:10.1007/s004310051133

Cited by 12 publications

(10 citation statements)

References 7 publications

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“…When compared with published equations, our R 2 values are similar or even higher than whatever other groups have presented. For example, in equations for FVC and FEV 1 the R 2 was between 66 and 74% (Hellmann & Goren, 1999), 60 and 65% (Pistelli et al ., 1992), and 62 and 65% (Haby et al ., 1994). The last two papers used one equation for boys and girls, with sex as a dummy variable.…”

Section: Discussionmentioning

confidence: 99%

Spirometric reference values in Estonian schoolchildren

Kivastik

Kingisepp

2001

Clinical Physiology

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This study was conducted to describe the relationship between anthropometric parameters and lung function in Estonian children, to determine the reference values for spirometry, and to compare these results with other data sets. The results are based on 1170 healthy non-smoking children (643 girls and 527 boys), aged 6-18 years. The spiroanalyser Pneumoscreen II (Jaeger) was used to register dynamic lung parameters. Natural logarithmic values of lung volumes, standing or sitting height and age were used in the final regression model. Prediction equations for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow, forced expiratory flows when 50 and 75% of FVC has been exhaled, and mean forced expiratory flow over the middle 50% of the FVC for both sexes are presented. In comparison with recent data from European children the reference values were close for FVC, the differences were bigger for FEV1 and forced expiratory flows, especially in taller children.

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Section: Discussionmentioning

confidence: 99%

Spirometric reference values in Estonian schoolchildren

Kivastik

Kingisepp

2001

Clinical Physiology

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“…It can be easily measured and correlates well with other lung function measurements. However, for the meaningful interpretation of PEFR results, it is necessary to establish the normal range of observations specific to a population, since there are wide variations of PEFR with geographic, racial, genetic and nutritional background [1,2,3] It is defined as "The largest expiratory flow rate achieved with a maximally forced effort from a position of maximal inspiration, expressed in liters/min" [4] Besides fulfilling the need of assessing the ventilatory function peak flow meter is a reliable and safe instrument. It is suitable for studies of respiratory function due to its portability and simplicity [5,6].…”

Section: Introductionmentioning

confidence: 99%

Variation of PEFR with height, weight and waist-hip ratio in medical students

2015

Int Arch Med

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Objective: The primary aim of our study was to assess the variation of PEFR with various anthropometric measurements in medical students of Karachi, Pakistan.Design: Cross-sectional study.Setting: Medical students of Karachi Medical and Dental College.Participants: 276 non-smoker healthy medical students composed of 168 females and 108 males.Variable parameters: They include mean age, body height and body weight and PEFR. They were marked separately for each gender. Results:The mean waist hip ratio in females was observed to be 0.843±0.111 in relation with that of mean PEFR value 452.97±65.84 L/min, whereas in males the mean waist hip ratio was 0.864±0.028 in relation with that of mean PEFR value 445.93±66.49 L/min. Also there is a statistically significant variation in PEFR with an increase in waist hip ratio. The mean height of males was 173.63±7.5 cm and weight was 61.81±11.25 Kg while mean height of females was 158.56±7.3 cm and weight was 49.33±9.04 Kg. PEFR is positively correlated with increase in height and weight up to a certain limit. Conclusion:The study concludes that PEFR is affected positively by variation in waist hip ratio; moreover young females have more

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“…Lung function differs from one population to other, depending on multiple factors including size and shape of the rib cage, respiratory muscles' strength and possibly parenchymal lung development (5). There are also other influences such as environmental pollution, socioeconomic conditions, nutritional status and exercise, which have direct and indirect effects on lung function (6)(7)(8).…”

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confidence: 99%

FEV1 and FVC pulmonary function reference values among 6-18-year-old children: a multi-centre study in Saudi Arabia

Al-Frayh¹,

Khoja²,

Alhusain³

et al. 2014

East Mediterr Health J

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It is important to establish lung function reference values for each population. This study aimed to determine the spirometric reference values for healthy Saudi Arabian children and adolescents and to derive prediction equations for these. A cross-sectional study was conducted among healthy schoolboys and girls aged 6-18 years old, selected randomly from the 6 administrative regions of Saudi Arabia. Data were collected by questionnaire and physical examinations including spirometry. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were significantly higher in males than females. Height was the anthropometric variable most strongly correlated with FEV1 (r = 0. 61), more so for males (r = 0.71) than females (r = 0.50). In males the multivariate linear regression model explained 53.9% of FEV1 and 35.1% of FVC variations. In females it explained 25.3% of FEV1 and 16.5% of FVC variations. All changes in R 2 were statistically significant.

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The necessity of building population specific prediction equations for clinical assessment of pulmonary function tests

Abstract: The development of population specific prediction equations for PFT parameters is necessary. Such equations should be used both in clinical assessment to minimize misclassification (healthy/sick child) and in epidemiological studies.

Cited by 12 publications

References 7 publications

Spirometric reference values in Estonian schoolchildren

Spirometric reference values in Estonian schoolchildren

Variation of PEFR with height, weight and waist-hip ratio in medical students

FEV1 and FVC pulmonary function reference values among 6-18-year-old children: a multi-centre study in Saudi Arabia

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