2023
DOI: 10.1002/viw.20220080
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The necessary of ternary amyloid classification for clinical practice: An alternative to the binary amyloid definition

Abstract: Visual interpretation is considered the gold standard for amyloid scans in clinical practice. However, dichotomous classification of amyloid deposition by visual reading always results in bias due to rater experience. Therefore, there is a need for a more lenient and flexible amyloid‐equivocal classification in clinical practice. A total of 461 participants were included in this study. Amyloid and glucose positron‐emission tomography was performed, and neuropsychological tests were evaluated. A disease‐specifi… Show more

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Cited by 7 publications
(4 citation statements)
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“…This analysis is also in line with recent endeavors that use deep learning model to subtype MCI 40 and to de ne the amyloid equivocality. 41 In the views of DL models, there exists ADdementia subjects being similar to naMCI or aMCI and SCD subjects being alike to HC or MCI (aMCI or naMCI). The existence of these subpopulations is underpinned by the clinical studies highlighting the heterogeneity and subtypes within AD and SCD populations.…”
Section: Discussionmentioning
confidence: 99%
“…This analysis is also in line with recent endeavors that use deep learning model to subtype MCI 40 and to de ne the amyloid equivocality. 41 In the views of DL models, there exists ADdementia subjects being similar to naMCI or aMCI and SCD subjects being alike to HC or MCI (aMCI or naMCI). The existence of these subpopulations is underpinned by the clinical studies highlighting the heterogeneity and subtypes within AD and SCD populations.…”
Section: Discussionmentioning
confidence: 99%
“…Seventy‐four participants underwent 18 F‐MK6240 PET/CT (Biograph128.mCT; Siemens, Germany) to survey tau pathology in the brain. Assessment of the amyloid PET images was performed through visual inspection by three experienced raters by consensus 25 . All tests and image acquisition were conducted over 1 month.…”
Section: Methodsmentioning
confidence: 99%
“…Assessment of the amyloid PET images was performed through visual inspection by three experienced raters by consensus. 25 All tests and image acquisition were conducted over 1 month.…”
Section: Methodsmentioning
confidence: 99%
“…made the judgment. Based on the distribution of cortical Aβ deposits, the diagnostic results were categorized as positive and negative (FigureS2) 27,28.…”
mentioning
confidence: 99%