The nature, time course and severity of methamphetamine withdrawal

McGregor, Catherine; Srisurapanont, Manit; Jittiwutikarn, Jaroon; Laobhripatr, Suchart; Wongtan, Thirawat; White, Jason M.

doi:10.1111/j.1360-0443.2005.01160.x

Cited by 384 publications

(280 citation statements)

References 33 publications

(40 reference statements)

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“…Previous research investigating the residual effects of methamphetamine have relied exclusively on self-reports of sleep behavior (McGregor et al 2005;Peck et al 2005), despite the fact that a large database comparing subjective estimates of sleep with objective sleep measures suggests that the two modalities may tap different aspects of the sleep experience (e.g., Coates et al 1982;Vitiello et al 2004). Indeed, the current data demonstrate that selfreports may dramatically overestimate the extent of sleep disruptions produced by methamphetamine.…”

Section: Discussionmentioning

confidence: 99%

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Residual effects of intranasal methamphetamine on sleep, mood, and performance

Perez

Kirkpatrick

Gunderson

et al. 2008

Drug and Alcohol Dependence

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Although intranasal methamphetamine abuse has increased, there are no published data investigating the residual effects of the drug under controlled conditions. Thus, the current study examined the residual effects of single-dose intranasal methamphetamine administration on a broad range of behavioral and physiological measures. Non-treatment seeking methamphetamine abusers (n = 11) completed this two-week, in-patient, within-participant, double-blind study. The study consisted of 4 two-day blocks of sessions; each block was separated by at least 24 hrs. At approximately 1000 hrs, on the first day of each block, participants received one of four intranasal methamphetamine doses (0, 12, 25, 50 mg/70 kg). Lights were turned out at 2300 hrs that evening and sleep measures were assessed. On the morning of the second day of each block, methamphetamine plasma levels, cardiovascular measures, mood, subjective reports of the previous evening's sleep, and psychomotor performance were assessed to determine residual drug effects. The larger methamphetamine doses (25 and 50 mg) markedly disrupted subjective measures of that night's sleep and some indices of next-day mood, but only the largest dose (50 mg) dose decreased objective measures of that night's sleep and increased next-day physiological measures. Methamphetamine did not produce any negative residual effects on early next-day performance. Future studies should assess methamphetamine-related residual effects following repeated doses administered over consecutive days.

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Section: Discussionmentioning

confidence: 99%

“…These deleterious effects appear to be exacerbated following abrupt discontinuation of methamphetamine use (Peck et al 2005). In addition, hypersomnia, increased depression-related symptoms, anxiety and methamphetamine craving are reported after cessation of methamphetamine use (McGregor et al 2005). …”

Section: Introductionmentioning

confidence: 99%

Residual effects of intranasal methamphetamine on sleep, mood, and performance

Perez

Kirkpatrick

Gunderson

et al. 2008

Drug and Alcohol Dependence

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“…Despite its stimulating effects, the literature on methamphetamine use indicates that methamphetamine users frequently report high levels of co-occurring psychiatric symptoms, particularly depression (Peck et al, 2005;Sommers et al, 2006;Zweben et al, 2004;Semple et al, 2005). Similar to alcohol, the causal relationship between methamphetamine and depression has not been established (Kalechstein et al, 2000) although it appears that depressive symptoms figure particularly prominently during withdrawal from methamphetamine use (McGregor et al, 2005;Rawson et al, 2002). Methamphetamine use has also been shown to impact a variety of self-reported and objective physical health measures, which could in turn affect HRQL (Greenwell and Brecht, 2003;Anglin et al, 2001;Alberston et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

The impact of illicit drug use and harmful drinking on quality of life among injection drug users at high risk for hepatitis C infection

Costenbader

Zule

Coomes

2007

Drug and Alcohol Dependence

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Background-Heavy alcohol use, hepatitis C and illicit drug use each have been shown to have negative impacts on health-related quality of life (HRQL). To date, considerations of HRQL have not played a prominent role in the design and measurement of intervention strategies for out-oftreatment at-risk populations.Methods-Data were collected from out-of-treatment IDUs recruited through street outreach in North Carolina. Multiple linear regression analyses were used to examine the independent effects of HCV status, harmful drinking (AUDIT), and illicit drug use on HRQL (SF-36).Results-Fifty-one percent of 619 study participants tested HCV-positive; 57% met criteria for harmful or hazardous drinking and 63% reported daily use of hard drugs. HRQL scores for this population were significantly lower than those of the general population. Multiple linear regression analyses demonstrated that harmful levels of alcohol consumption and use of methamphetamine in the past month had the strongest associations with reduced HRQL.Conclusions-Given the high rates of HCV in most IDU communities, new harm reduction approaches are needed for these populations which focus beyond prevention to the functioning and well-being of those already infected. In particular, reducing heavy alcohol use in addition to slowing HCV progression shows promise for improving HRQL.

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“…The incidence can vary from as low as 2 % to as high as 49 % in some studies. However, unlike its cocaine counterpart, methamphetamine withdrawal in neonates rarely necessitates pharmacologic intervention [8,11,12].…”

Section: Neonatal Abstinence Syndromementioning

confidence: 99%

Stimulant Methamphetamine and Dextromethorphan Use Among Thai Adolescents: Implications for Health of Women and Children

Chomchai

Manaboriboon

2012

J. Med. Toxicol.

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For over a decade, amphetamine-type stimulants have made their way into the adolescent culture of Thailand. Coupled with the more recent emergence of the legal, overthe-counter cough medicine dextromethorphan (DM), they represent the most commonly abused substances among Thai youths today. Methamphetamine is the second most popular drug of abuse in Thailand, the first being cannabis. It is available in the crystalline version, ICE, and the less pure methamphetamine tablets. The tablets are frequently crushed and smoked. Its use has gained enormous popularity among teenagers and young adults, including women of child-bearing age. As such, it has become the most common drug being detected in the urine of peripartum women, resulting in peripartum and postpartum complications for both mother and child. DM is a newer drug which has gained popularity among middle school and high school students due to its easy availability as a single product over the counter. It is usually taken with soft drinks at parties and gathering. It is metabolized by CYP4502D6 to dextrorphan, the substance responsible for the feeling of euphoria. Consequently, those who are poor metabolizers often experience the "negative" effects associated with the drug. The recreational use of methamphetamine and dextromethorphan in teenagers and young adults in Thailand is a serious problem. Recognizing not only the toxicological but also the emotional and psychosocial impacts of these drugs on Thai youth is an integral part of approaching the problem.

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The nature, time course and severity of methamphetamine withdrawal

Cited by 384 publications

References 33 publications

Residual effects of intranasal methamphetamine on sleep, mood, and performance

Residual effects of intranasal methamphetamine on sleep, mood, and performance

The impact of illicit drug use and harmful drinking on quality of life among injection drug users at high risk for hepatitis C infection

Stimulant Methamphetamine and Dextromethorphan Use Among Thai Adolescents: Implications for Health of Women and Children

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