The nature of the fungal cargo induces significantly different temporal programmes of macrophage phagocytosis

“Under Pressure” – How fungi evade, exploit, and modulate cells of the innate immune system

“…It is tempting to speculate that this may benefit the macrophage-resistant C. glabrata by attracting suitable host cells. A recent publication in fact revealed that a large proportion of macrophages exhibits enhanced kinesis towards C. glabrata (and C. albicans ) in comparison with other pathogenic fungi [189] . Moreover, C. glabrata is found surrounded by monocytes in experimental murine infections [185] .…”

“We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes

“…In addition, the degree of physical membrane stress and the kinetics of escape are strongly influenced by the fungal morphology. Fungal species that filament inside macrophages, namely, C. albicans , A. fumigatus , and Mucor species (Gilbert et al, 2014; Nicolas et al, 2020; Perez‐Arques et al, 2019), have a higher capacity to damage host cells than nonfilamenting fungal species like C. glabrata , C. neoformans , H. capsulatum , Rhizopus species, B. dermatitidis , and P. brasiliensis , which proliferate intracellularly as yeast cells or persist as spores (Alonso et al, 2022; Gilbert et al, 2014; Giusiano, 2021; Johnston & May, 2013; Kumar et al, 2019; Newman, 1999; Nicolas et al, 2020; Sterkel et al, 2015).…”

“…Potentially, C. glabrata induces specifically this cytokine to attract suitable host cells, in order to persist within them. A recent publication in fact revealed that a large proportion of macrophages exhibits enhanced kinesis toward C. glabrata (and C. albicans ) in comparison with other pathogenic fungi (Alonso et al, 2022). Moreover, C. glabrata was found to be surrounded by monocytes and even inside mononuclear cells in immunocompetent mice, and notably could still be isolated from organs four weeks after infection (Jacobsen et al, 2010).…”