1990
DOI: 10.1097/00000372-199006000-00006
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The Nature of Hyaline (Eosinophilic) Globules and Vascular Slits of Kaposiʼs Sarcoma

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Cited by 65 publications
(22 citation statements)
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“…Intracellular junctions between neoplastic endothelial cells are frequently defective allowing the extravasation of large numbers of erythrocytes from vessel lumens into the surrounding tissue. [50][51][52][53] These renegade cells become more numerous as the disease progresses and abnormal networks of slitlike vascular spaces expand. Erythrophagocytosis by KS cells is also a common feature.…”
Section: Discussionmentioning
confidence: 99%
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“…Intracellular junctions between neoplastic endothelial cells are frequently defective allowing the extravasation of large numbers of erythrocytes from vessel lumens into the surrounding tissue. [50][51][52][53] These renegade cells become more numerous as the disease progresses and abnormal networks of slitlike vascular spaces expand. Erythrophagocytosis by KS cells is also a common feature.…”
Section: Discussionmentioning
confidence: 99%
“…by guest www.bloodjournal.org From described the presence of hyaline globules in plaque-and nodularstage KS, and histologic staining has revealed that these are the remnants of degenerated erythrocytes. 51 In light of these histologic findings, it is conceivable that up-regulation of HO-1 by KSHV infection could confer a selective advantage to KS cells within the high heme lesional microenvironment compared with neighboring uninfected cells. The availability of potent inhibitors of HO-1 in clinical use elsewhere 55,56 makes this enzyme a potentially important treatment target in KS.…”
Section: Discussionmentioning
confidence: 99%
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“…The clinical presentation was quite unusual; the endoscopy revealed numerous polypoid mucosal nodules ®lling the lumen of the rectum and sigmoid colon. Microscopically, besides the classical pattern of KS as seen elsewhere, the striking histologic feature was the presence of eosinophilic intracytoplasmic globules, thought to be phagocized sequestrated red blood cells, in the neoplastic cells [18], and Cowdry type A nuclear inclusions caused by HHV-8 infection, which ®ndings have not been described except skin KS [19].…”
Section: Discussionmentioning
confidence: 80%
“…These structures are thought to represent digested erythrocytes as the neoplastic cells seem to have phagocytic activity. 21 Based on immunolabeling studies, KS is best regarded as a lesion of lymphatic endothelial cells, as it expresses CD34, CD31, Fli-1, VEGFR-3, and podoplanin (D2-40). [22][23][24][25] Virtually all examples show nuclear labeling with HHV-8 antibodies (Figure 3c).…”
Section: Kaposi Sarcomamentioning
confidence: 99%