The nature of fibrous dysplasia

Feller, Liviu; Wood, Neil; Khammissa, R A G; Lemmer, J; Raubenheimer, Erich J.

doi:10.1186/1746-160x-5-22

Cited by 91 publications

(111 citation statements)

References 18 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Polyostotic fibrous dysplasia has its onset mainly in children younger than 10 years of age, and the lesions grow with the child and stabilize after puberty. 6,15 The ratio of occurrence of polyostotic to monostotic fibrous dysplasia is 3:7.…”

Section: Epidemiologymentioning

confidence: 99%

“…6 However, McCune-Albright syndrome has a clear female predilection. 3 Any bone may be affected by fibrous dysplasia.…”

Section: Epidemiologymentioning

confidence: 99%

“…Other signs and symptoms include bone pain, pathologic fractures, and bone deformities. 6,7 Malignant transformation is rare, and is usually precipitated by radiation therapy. 6,8 The diagnosis of fibrous dysplasia can be made by radiologic imaging and confirmed by bone biopsies.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 Malignant transformation is rare, and is usually precipitated by radiation therapy. 6,8 The diagnosis of fibrous dysplasia can be made by radiologic imaging and confirmed by bone biopsies. Computed tomography (CT) and magnetic resonance imaging are useful for evaluating the soft tissue components and the entire extent of a lesion.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fibrous dysplasia of bone: a clinicopathologic review

Mohan¹

2011

PLMI

View full text Add to dashboard Cite

Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gsα and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.

show abstract

Section: Epidemiologymentioning

confidence: 99%

“…6 However, McCune-Albright syndrome has a clear female predilection. 3 Any bone may be affected by fibrous dysplasia.…”

Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fibrous dysplasia of bone: a clinicopathologic review

Mohan¹

2011

PLMI

View full text Add to dashboard Cite

show abstract

“…Malignant transformation is usually rare and is usually precipitated by radiation therapy. [3][4][5] Ichthyoses are a group of disorder of cornification which may be inherited or acquired. The inherited form of the disease usually presents in infancy and persists throughout the life.…”

Section: Imentioning

confidence: 99%

Monostotic Fibrous Dysplasia and Ichthyosis Vulgaris ------ A Rare Association

Mondal¹,

Chowdhury²,

Bandyopadhyay³

2013

IOSR-JDMS

View full text Add to dashboard Cite

show abstract

Generalized Radiopacities of the Craniofacial Skeleton

Omami

Wiggins

2018

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

An adolescent girl presented with a history of multiple, slowly growing masses of the face and head. The lesions were first reported when she was 5 years of age and gradually increased in size. However, her medical history was otherwise unremarkable. On clinical examination, the lesions were hard in consistency with normal overlying skin. There was significant bilateral exophthalmos (the left eye was more pronounced), with visual changes, and dental malocclusion. However, there were no clinical signs of endocrinopathy. A skeletal survey showed no involvement of other bones. The patient's serum calcium, phosphate, alkaline phosphatase, thyroid, and parathyroid hormone levels were within normal limits. A computed tomographic (CT) examination of the craniofacial skeleton was performed (Figure).

show abstract

The nature of fibrous dysplasia

Cited by 91 publications

References 18 publications

Fibrous dysplasia of bone: a clinicopathologic review

Fibrous dysplasia of bone: a clinicopathologic review

Monostotic Fibrous Dysplasia and Ichthyosis Vulgaris ------ A Rare Association

Generalized Radiopacities of the Craniofacial Skeleton

Contact Info

Product

Resources

About