The Nature and Impact of Domestic Violence Across Age Cohorts

Wilke, Dina J.; Vinton, Linda

doi:10.1177/0886109905277751

Cited by 71 publications

(81 citation statements)

References 23 publications

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“…The time courses of Ang-1, Tie2, and VEGF mRNA after exposure to hypoxia were comparable in both methods (data not shown). As the Ang-1/Tie2 system and VEGF signaling pathways play important roles for endothelial function, and endothelial dysfunction has been reported in experimental and human PH, expression of eNOS was also evaluated [1,2,3,4, 11]. mRNA expression of eNOS was significantly upregulated after 0.5–21 days.…”

Section: Resultsmentioning

confidence: 99%

“…As Tie2 and VEGF are known as survival factors of endothelial cells, the decreases in expression might result in apoptosis of vascular cells [1,2,3,4, 11]. Thus we next investigated the expression of caspase-3, which is known as an important effector enzyme for apoptosis.…”

Section: Resultsmentioning

confidence: 99%

“…The growth factors that specifically act on the vasculature are limited to families known by their prototypical members, the vascular endothelial growth factor (VEGF) family and the angiopoietin family [1,2,3]. Both angiopoietins and VEGF achieve their specificity based on the limited distribution of their receptors, which are expressed on the vascular walls [2].…”

Section: Introductionmentioning

confidence: 99%

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Downregulation of Angiopoietin-1 and Tie2 in Chronic Hypoxic Pulmonary Hypertension

Yamamoto

Takahashi²,

Kojima³

et al. 2007

Respiration

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Background: Angiopoietins, newly discovered vascular-specific growth factors, and vascular endothelial growth factors (VEGF) play distinct and complementary roles in angiogenesis and vascular maturation. However, the exact roles of angiogenic factors in the adult pulmonary vasculature remain unclear. Objective: To elucidate possible roles of angiopoietins and VEGF in the development of hypoxic pulmonary hypertension (PH), changes in the expression of angiogenic factors were examined. Methods: The cellular distribution and expression of angiopoietins and their receptor Tie2 and VEGF were investigated by RT-PCR, immunoblot, and immunohistochemical methods in rat lung under normal and hypoxic conditions. Results: During the development of PH with vascular remodeling characterized by a decrease in vessel density of intrapulmonary arteries, protein expression of angiopoietin-1 (Ang-1), Tie2, and VEGF significantly decreased in the pulmonary arteries, and Tie2 receptor was inactivated in the lung. The expression of angiopoietin-3 (Ang-3), an endogenous antagonist of Ang-1, significantly increased in the intima under hypoxic conditions. Conclusions: Since both Ang-1/Tie2 and VEGF promote angiogenesis and vascular survival, and play protective roles in the adaptation of microvascular changes during the onset of PH, the downregulation of both Ang-1/Tie2 and VEGF and upregulation of Ang-3 appear to be associated with vascular rarefaction and the development of hypoxic PH.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Downregulation of Angiopoietin-1 and Tie2 in Chronic Hypoxic Pulmonary Hypertension

Yamamoto

Takahashi²,

Kojima³

et al. 2007

Respiration

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“…This constellation of factors may make older women more difficult to serve in domestic violence programs. Wilke and Vinton's (2005) study examined the nature and extent of IPV and its impact on psychosocial functioning among women of different age groups. Findings confirmed that older women experience just as much IPV as younger women, but had more needs than younger women.…”

Section: Culturally Competent Interventions For Elder Intimate Partnementioning

confidence: 99%

Korean Older Intimate Partner Violence Survivors in North America: Cultural Considerations and Practice Recommendations

Shim

Nelson-Becker

2009

Journal of Women & Aging

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While literature on elder abuse has expanded, elder abuse by intimate partners has been less investigated. Even less is known about intimate partner violence among older Koreans living in North America. This article identifies important cultural considerations for individuals helping the Korean older adult community beginning with the definition of intimate partner violence in this community and barriers to leaving that include traditional views of the East Asian self. Current practice interventions are discussed and recommendations for future practice such as healing han, the accumulated suffering from years of abuse, are suggested. The ultimate goal of this paper is to expand awareness in order to develop the best culturally competent prevention and intervention practice for Korean older intimate partner violence survivors in North America.

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“…While the disproportionate risk of young women (e.g., of childbearing age), particularly those who are pregnant, is well documented [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16], a growing empirical literature also characterizes the significant prevalence and public health implications of interpersonal abuse exposure, including verbal, physical or sexual abuse, neglect, and financial exploitation, among older, post-menopausal women [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. For example, Zink et al [33] conducted a telephone survey investigating prevalence of abuse exposure among more than 3500 women over age 55.…”

Section: Introductionmentioning

confidence: 99%

Cross-Sectional and Longitudinal Risk of Physical Impairment in a Cohort of Postmenopausal Women Who Experience Physical and Verbal Abuse

2015

The Gerontologist

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Background: Exposure to interpersonal violence, namely verbal and physical abuse, is a highly prevalent threat to women's health and well-being. Among older, post-menopausal women, several researchers have characterized a possible bi-directional relationship of abuse exposure and diminished physical functioning. However, studies that prospectively examine the relationship between interpersonal abuse exposure and physical functioning across multiple years of observation are lacking. To address this literature gap, we prospectively evaluate the association between abuse exposure and physical functioning in a large, national cohort of post-menopausal women across 12 years of follow-up observation. Methods: Multivariable logistic regression was used to measure the adjusted association between experiencing abuse and physical function score at baseline in 154,902 Women's Health Initiative (WHI) participants. Multilevel modeling, where the trajectories of decline in physical function were modeled as a function of time-varying abuse exposure, was used to evaluate the contribution of abuse to trajectories of physical function scores over time. Result: Abuse was prevalent among WHI participants, with 11 % of our study population reporting baseline exposure. Verbal abuse was the most commonly reported abuse type (10 %), followed by combined physical and verbal abuse (1 %), followed by physical abuse in the absence of verbal abuse (0.2 %). Abuse exposure (all types) was associated with diminished physical functioning, with women exposed to combined physical and verbal abuse presenting baseline physical functioning scores consistent with non-abused women 20 years senior. Results did not reveal a differential rate of decline over time in physical functioning based on abuse exposure. Conclusions: Taken together, our findings suggest a need for increased awareness of the prevalence of abuse exposure among postmenopausal women; they also underscore the importance of clinician's vigilance in their efforts toward the prevention, early detection and effective intervention with abuse exposure, including verbal abuse exposure, in post-menopausal women. Given our findings related to abuse exposure and women's diminished physical functioning at WHI baseline, our work illuminates a need for further study, particularly the investigation of this association in younger, pre-menopausal women so that the temporal ordering if this relationship may be better understood.

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The Nature and Impact of Domestic Violence Across Age Cohorts

Cited by 71 publications

References 23 publications

Downregulation of Angiopoietin-1 and Tie2 in Chronic Hypoxic Pulmonary Hypertension

Downregulation of Angiopoietin-1 and Tie2 in Chronic Hypoxic Pulmonary Hypertension

Korean Older Intimate Partner Violence Survivors in North America: Cultural Considerations and Practice Recommendations

Cross-Sectional and Longitudinal Risk of Physical Impairment in a Cohort of Postmenopausal Women Who Experience Physical and Verbal Abuse

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