The Nature and Determinants of Neuropsychological Functioning in Late-LifeDepression

Butters, Meryl A.; Whyte, Ellen M.; Nebes, Robert D.; Begley, Amy; Dew, Mary Amanda; Mulsant, Benoit H.; Zmuda, Michelle; Bhalla, Rishi K.; Meltzer, Carolyn C.; Pollock, Bruce G.; Reynolds, Charles F.; Becker, James T.

doi:10.1001/archpsyc.61.6.587

Cited by 546 publications

(520 citation statements)

References 78 publications

Supporting

Mentioning

448

Contrasting

Unclassified

Order By: Relevance

“…Além disso, pacientes idosos com depressão vascular freqüentemente têm disfunção cognitiva, em especial alterações no processamento da informação, funções visuoespaciais e habilidades executivas, as quais estão associadas à diminuição no desempenho das atividades de vida diária e ao comprometimento funcional, que podem persistir mesmo após a remissão dos sintomas depressivos (Butters et al, 2004).…”

Section: Discussionunclassified

Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases

Barcelos

Faria²,

Grossi³

et al. 2007

Rev. psiquiatr. clín.

View full text Add to dashboard Cite

Resumo Contexto: Entre os transtornos neuropsiquiátricos ocasionados por eventos cerebrovasculares, a depressão vascular é pouco diagnosticada por médicos não especialistas, causando aumento da morbimortalidade de pacientes idosos. Caso clínico: Trata-se de um paciente com 67 anos que apresentou resposta parcial a tratamento com inibidores da recaptura de serotonina e efeitos adversos autonômicos graves com outros antidepressivos. A adição de rivastigmina ao citalopram promoveu sucesso terapêutico, com redução de 23 para 7 pontos, na escala de Hamilton para depressão. Discussão: O resultado obtido traz novas perspectivas para o tratamento da depressão vascular, sendo necessários ensaios clínicos controlados que evidenciem o benefício da adição dos inibidores das colinesterases aos antidepressivos no tratamento destes pacientes. , R. et al. / Rev. Psiq. Clín 34 (6); 290-293, 2007 Palavras-chave: Depressão vascular, demência vascular, doença de Alzheimer, AVC, neuroimagem. Barcelos AbstractContext: Among neuropsychiatric disorders caused by cerebrovascular factors, vascular depression is diagnosed in a small degree by general practitioners, causing morbid-mortality increase in elderly. Case report: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM-D). Discussion: The result obtained brings new perspectives to the treatment of vascular depression, providing that randomized controlled trials with larger sample sizes confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of these patients. , R. et al. / Rev. Psiq. Clín 34 (6); 290-293, 2007 Barcelos

show abstract

Section: Discussionunclassified

Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases

Barcelos

Faria²,

Grossi³

et al. 2007

Rev. psiquiatr. clín.

View full text Add to dashboard Cite

show abstract

“…Yet, these factors appear to trigger suicidal behavior only in a small fraction of exposed individuals, and the nature of the suicidal diathesis in late-life remains poorly understood. For example, cognitive impairment, highly prevalent in late-life depression (3–6), has not been adequately investigated as a component of the suicidal diathesis in late-life (7, 8). …”

Section: Introductionmentioning

confidence: 99%

Impaired Executive Function in Contemplated and Attempted Suicide in Late Life

Gujral

Dombrovski

Butters

et al. 2014

The American Journal of Geriatric Psychiatry

Self Cite

View full text Add to dashboard Cite

Objective Executive deficits may play an important role in late-life suicide. Yet, current evidence in this area is inconclusive and does not indicate whether these deficits are broadly associated with suicidal ideation or specific to suicidal behavior. This study examined global cognition and specifically executive function impairments as correlates of suicidal ideation and suicidal behavior in depressed older adults, with the goal of extending an earlier preliminary study. Design Case-control study. Setting University-affiliated psychiatric hospital. Participants All were aged 60+: 83 depressed suicide attempters, 43 depressed individuals having suicidal ideation with a specific plan, 54 non-suicidal depressed participants, and 48 older adults with no history of psychiatric disorders. Measurements Global cognitive function - Dementia Rating Scale (DRS), Executive function - Executive Interview (EXIT). Results Both suicide attempters and suicide ideators performed worse than the two comparison groups on the EXIT, with no difference between suicide attempters and suicide ideators. On the DRS total score, as well as on Memory and Attention subscales, suicide attempters and ideators and non-suicidal depressed subjects performed similarly and were impaired relative to with non-psychiatric control subjects. Controlling for education, substance use disorders, and medication exposure did not affect group differences in performance on either the EXIT or DRS. Conclusions Executive deficits, captured with a brief instrument, are associated broadly with suicidal ideation in older depressed adults but do not appear to directly facilitate suicidal behavior. Our data are consistent with the idea that different vulnerabilities may operate at different stages in the suicidal process.

show abstract

“…Depression has been viewed as both a risk factor and a prodrome to the condition, and a history of depression doubles the change of developing symptoms of dementia. [5][6][7] Dementia is best defined as an umbrella term that encapsulates a number of symptoms caused by the degeneration of the brain. People who have dementia have difficulty in cognitive functions such as memory, problem solving, emotional control, and impaired intellectual functioning.…”

Section: Introductionmentioning

confidence: 99%

Marine Algae as a Source of Prevention and Relief in Those With Depression and Dementia

Williams¹

2017

WJPPS

View full text Add to dashboard Cite

Although not as common as those in young adults, the prevalence of late-onset depression has been reported to be increasing in its global incidence. Late-onset depression is generally a product of cognitive deficit and decline, rather than genetic history. Past studies have shown links between the development of depression, dementia, and vascular diseases especially with respect to the nutritional constituents as causative factors. Individuals with depression and dementia tend to be deficient in folate, polyunsaturated fatty acids, and vitamin B 12 . Folate and vitamin B 12 are essential to the metabolism of neurotransmitters necessary in mood regulation (dopamine, serotonin, and noradrenalin), as well as the conversion of homocysteine to cysteine. High levels of homocysteine may result in damage to neuronal pathways and DNA, increasing the risk of dementia. Another risk factor of dementia is the rapid metabolism of neurotransmitter acetylcholine (ACh) due to the enzyme acetylcholinesterase (AChE).Various types of seaweeds have been found to contain properties and nutrients to alleviate such symptoms and risk factors. These remedies include high levels of polyunsaturated fatty acids, folate, vitamin B 12 , AChE inhibition and fucoidan. Fucoidan is a compound found in seaweeds that has anti-inflammatory and neuroprotective properties. Further research with the incorporation of seaweeds into common diets may allow for natural prevention and treatment.

show abstract

The Nature and Determinants of Neuropsychological Functioning in Late-LifeDepression

Cited by 546 publications

References 78 publications

Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases

Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases

Impaired Executive Function in Contemplated and Attempted Suicide in Late Life

Marine Algae as a Source of Prevention and Relief in Those With Depression and Dementia

Contact Info

Product

Resources

About