The naturalistic oscillating patterns of alcohol consumption in alcoholic methadone patients.

Bickel, Warren K.; Rizzuto, Pamela

doi:10.15288/jsa.1991.52.454

Cited by 15 publications

(4 citation statements)

References 16 publications

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“…3). This pattern of drinking has been reported in other studies that examined the ADE phenomenon (Sinclair, 1979;Sinclair and Senter, 1968;Sinclair and Gribble, 1985) and after periods of excessive alcohol intake in rats (Files et al, 1993), monkeys, and humans (Bickel and Rizzuto, 1991). The similarity between the P rat pattern of alcohol consumption and human alcohol consumption has been argued to confirm the validity of the P rat as an animal model of alcoholism (Files et al, 1993).…”

Section: Discussionsupporting

confidence: 78%

Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Rodd-Henricks

McKinzie

Shaikh

et al. 2000

Alcoholism Clin & Exp Res

119

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Section: Discussionsupporting

confidence: 78%

Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Rodd-Henricks

McKinzie

Shaikh

et al. 2000

Alcoholism Clin & Exp Res

119

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“…Another factor that may cause problems for studies is the possibility that alcohol consumption oscillates in methadone-using patients (Bickel & Rizzuto, 1991). Thus, the waxing and waning of alcohol consumption and the time of assessment may have had an impact on the conclusions of the studies included in the review.…”

Section: Discussionmentioning

confidence: 99%

The effect of methadone maintenance treatment on alcohol consumption: A systematic review

Srivastava

Kahan

Ross

2008

Journal of Substance Abuse Treatment

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“…While recent systematic reviews have indicated that alcohol, heroin and methadone are correlated, the impact of enrolment in MMT on heavy drinking has not been fully characterized [5,14,15]. Phases of heavy drinking seem to follow after bouts of abstinence from heroin use, and this pattern often repeats over time [16]. However, specifics of this relationship remain unclear.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Enrolment in Methadone Maintenance Therapy on Initiation of Heavy Drinking among People Who Use Heroin

et al. 2016

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Background: There is equivocal evidence regarding whether people who use heroin substitute heroin for alcohol upon entry to methadone maintenance therapy (MMT). We aimed to examine the impact of MMT enrolment on the onset of heavy drinking among people who use heroin. Methods: We derived data from prospective, community-based cohorts of people who inject drugs in Vancouver, Canada, between December 1, 2005, and May 31, 2014. Multivariable extended Cox regression analysis examined the effect of MMT enrolment on the onset of heavy drinking among people who used heroin at baseline. Results: In total, 357 people who use heroin were included in this study. Of these, 208 (58%) enrolled in MMT at some point during follow-up, and 115 (32%) reported initiating heavy drinking during follow-up for an incidence density of 7.8 events (95% CI 6.4-9.5) per 100 person-years. The incidence density of heavy drinking was significantly lower among those enrolled in MMT at some point during follow-up compared to those who did not (4.6 vs. 16.2; p < 0.001). MMT enrolment was not significantly associated with time to initiate heavy drinking (adjusted relative hazard (ARH) 1.27; 95% CI 0.78-2.07) after adjustment for relevant demographic and substance-use characteristics. Age and cannabis use were the only variables that were independently associated with the time to onset of heavy drinking (ARH 0.74; 95% CI 0.58-0.94 and ARH 2.06; 95% CI 1.32-3.19, respectively). Conclusion: In this study, MMT enrolment did not predict heavy drinking and may even appear to decrease the initiation of heavy drinking. Our findings suggest younger age and cannabis use may predict heavy drinking. These findings could help inform on-going discussions about the effects of opioid agonist therapy on alcohol consumption among people who use heroin.

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The naturalistic oscillating patterns of alcohol consumption in alcoholic methadone patients.

Cited by 15 publications

References 16 publications

Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

The effect of methadone maintenance treatment on alcohol consumption: A systematic review

The Impact of Enrolment in Methadone Maintenance Therapy on Initiation of Heavy Drinking among People Who Use Heroin

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