The Natural Products Chemistry of the Gorgonian Genus Pseudopterogorgia (Octocorallia: Gorgoniidae)

Marrero, Jeffrey; Rodrı́guez, Ileana I.; Rodrı́guez, Abimael D.

doi:10.1016/b978-008045382-8.00637-7

Cited by 12 publications

(13 citation statements)

References 296 publications

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“…The discovery of selective and potent therapeutic activity of pseudopterosins and seco -pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae [ 1 – 14 ] and the high degree of chemical variation among specimens collected at different locations throughout the Caribbean region [ 1 , 2 ], have motivated several authors to pursue this field of study. Thus far, 30 pseudopterosins (PsA-Y, iso -PsE, 2- O -Ac-PsQ, 3- O -Ac-PsQ, 2- O -Ac-PsU and 2- O -Ac-PsQ) [ 3 – 11 ] and 11 seco- pseudopterosins ( seco- PsA-K) [ 8 – 13 ] have been isolated from specimens collected in the Bahamas, Bermuda, the Florida Keys and the Colombian islands of San Andrés and Providencia.…”

Section: Introductionmentioning

confidence: 99%

“…PsA-E, PsK, PsX, PsY and seco- PsA-D showed excellent and selective activity against the Gram-positive bacteria Streptococcus pyogenes , Staphylococcus aureus , and Enterococcus faecalis [ 5 , 12 ]. Pseudopterosins are also used in several skin care products [ 1 , 17 ]. Methopterosin is a simple derivative of PsA and has completed Phase I and II clinical trials as a wound healing agent [ 17 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

et al. 2011

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To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI50 values between 5.8 μM to 12.0 μM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC50 2.9–4.5 μM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC50 3.1–3.8 μM) against E. faecalis, comparable to the reference drug vancomycin (4.2 μM).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

et al. 2011

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“…Asimismo, mostraron ser letales a la Artemia salina (CL 50 < 1000 μg/ml) presentando mayor actividad, en todos los casos, las fracciones. La quimiotaxonomía de gorgonios pertenecientes a los géneros Eunicea, Muricea y Pseudopterogorgia, representativos de la fauna invertebrada en la región de las Indias Occidentales, ha demostrado que son una fuente de sustancias biactivas con potencial aplicación farmacológica (Gutiérrez et al, 2006;Lorenzo et al, 2006;Kate et al, 2010;Marrero et al, 2010;Cuadrado et al, 2010;Correa et al, 2011;Reina et al, 2011;Correa et al, 2012;Wei et al, 2012). El presente trabajo constituye una recopilación de varias investigaciones realizadas en Laboratorio de Lípidos y Productos Naturales del Departamento de Química de la Universidad de Oriente, Venezuela, en los cuales se propuso estudiar químicamente los extractos de los octocorales Eunicea sp., Muricea sp.…”

Section: Bioensayo Con Nauplios De Artemia Salinaunclassified

Vii Foro Iberoamericano De Los Recursos Marinos Y La Acuicultura

Senior¹,

Lemus²,

González³

et al. 2016

Preprint

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Los objetivos del Foro Iberoamericano de los Recursos Marinos y la Acuicultura(FIRMA) siempre han constituido un reto para la organización en cualquier paísdonde se ha desarrollado, pero siempre un puñado de voluntades ha generadojunto con los participantes una ola académica llena de hermandad que haconllevado al éxito, el VII FIRMA Ecuador 2014, independientemente decualquier obstáculo, no ha sido la excepción, confirmando que es uno de loseventos más importantes en la Evaluación de los Recursos Marinos y laAcuicultura, y al menos único en su forma y objetivos.

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“…One of the potential sources of compounds with cytotoxic activity are marine invertebrates, among them soft corals (Orders Alcyonacea and Gorgonacea, Class Anthozoa, Phylum Cnidaria [1]). These organisms are prolific sources of compounds, with novel structures conferring them marked biological activity such as anti-inflammatory, antiseptic, acetylcholinesterase inhibition, quorum sensing inhibition and cytotoxicity [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

New Diterpenes Isolated from the Colombian Caribbean Soft Coral Pseudoplexaura flagellosa and Their Cytotoxic Properties

Estrada¹,

Puyana²,

Castellanos³

et al. 2019

Rec.Nat.Prod.

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Studies about secondary metabolites isolated from soft corals around the world have proven the potential of these organism as producers of compounds with a potent cytotoxic activity. In this work, we obtained the extract of Pseudoplexaura flagellosa collected in Santa Marta, Colombia, the cytotoxic activity of this extract, fractions and compounds was established against SiHa (ATCC® HTB-35™), MDA-MB-231 (ATCC® HTB26™), A549 (ATCC® CRM-CCL-185™), PC3 (ATCC® CRL1435), and L929 (ATCC® CCL1™) cell lines. The results showed that the extract of soft coral P. flagellosa has cytotoxic activity with an IC50 of 35.4, 72.3, 49.8 and 40.5 μg/mL against SiHa, A549, PC3 and MDA-MB-231 cell lines, respectively. Thus, this extract was repeatedly subjected to different chromatographic columns and final purification of these fractions afforded pure compounds 1 -4, which were elucidated by 1D and 2D NMR experiments including 1 H, 13 C, COSY, HSQC, HMBC and NOESY, and HRESIMS. In addition, Mosher method was used to establish the stereochemistry of compound 2 and chemical interconversion allow establishing the stereochemistry of compound 1. These results let to conclude that compound 2 is a new stereoisomers of acetylated asperdiol previously reported on literature. Additionally, three analogues 5, 6, and 7 were synthesized from compound 1 and the cytotoxic activity of all compounds was evaluated using doxorubicin as positive control. The results showed that 6 (IC50 of 19.3, 23.7, 13.4 and 18.7 μg/mL against SiHa, A549, PC3 and MDA-MB-231, respectively) was the most active compound against all the cancer cell lines.

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The Natural Products Chemistry of the Gorgonian Genus Pseudopterogorgia (Octocorallia: Gorgoniidae)

Cited by 12 publications

References 296 publications

Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

Vii Foro Iberoamericano De Los Recursos Marinos Y La Acuicultura

New Diterpenes Isolated from the Colombian Caribbean Soft Coral Pseudoplexaura flagellosa and Their Cytotoxic Properties

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