The Natural History of Untreated Breast Cancer

Herring, L.

doi:10.3322/canjclin.14.1.3

Cited by 14 publications

(17 citation statements)

References 3 publications

(3 reference statements)

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“…This early reporting in case of malignant breast lump clearly suggests increasing awareness of patients about the disease in the developing nation over the period of time. 17 In the present study, by far the most common presenting feature was painless mass in the breast (60.78%) followed by painful mass (13.73%) and associated features like ulceration of the skin, retraction of nipple and nipple discharge.…”

Section: Discussionmentioning

confidence: 49%

A clinico-pathological study of malignant breast lump in a tertiary care hospital in Kosi region of Bihar, India

et al. 2016

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Section: Discussionmentioning

confidence: 49%

A clinico-pathological study of malignant breast lump in a tertiary care hospital in Kosi region of Bihar, India

et al. 2016

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“…22 The survival time of the untreated patients at a same clinical stage of the disease varies between several months to several decades. 23 At the end of our study, when we examined the ultimate condition of the patients, we found that 79.2% were disease-free survivors, 17% had progression and 3.8% died.…”

Section: 12mentioning

confidence: 68%

Retrospective Evaluation of the Female Patients with Breast Cancer: Western Black Sea Region, Unicentered, Clinical Data of Oncology

Engın¹

2013

UHOD

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ABSTRACBreast cancer is the most common female cancer in the world wide with 30% of all women cancer and second most common cause of cancer death in women. Oncology department of Bulent Ecevit University Faculty of Medicine is the only cancer center in western part of Black Sea region. We investigated retrospectively our data of women breast cancer between the period of 2000 and 2010 in this region. The mean age of the study population was 49.90 ± 12 years and mean follow-up time was 4 ± 2 years. The distribution of patients by the age, 25% or patients under 40 years old, 32% between the 40-50 years old and 43% of them over the 50 years old. 92.6% of the patients were presented with a palpable mass. The most common type of breast cancer was invasive ductal carcinoma (IDC) in 312 patients (80%). Prognosis of the study population; 309 patients (80%) are surviving without any disease. Sixty-six patients (17%) had progression, 7 of 390 patients (1,8%) had local recurrence and 15 patients (3.8%) died. While the breast cancer is one of the most commonly seen solid organ tumors in Black Sea region and, based on the literature, no significant differences were observed for prognostic factors, longer life expectancy of the patients with advanced stage disease may be attributed to higher number of patients with hormonal positivity and therapy adherence. Keywords: Breast cancer, Woman, Prognosis, Survival ÖZET Meme Kanserli Kad›nlar›n Retrospektif Analizi: Bat› Karadeniz Bölgesi Tek Merkez Onkoloji Klinik VerileriMeme kanseri tüm dünyada kad›nlardaki en s›k kanser türü olup kad›n kanserlerinin %30'nu oluflturur ve kad›nlarda kansere ba¤-l› en s›k ölüm nedenidir. Bulen Ecevit Üniversitesi Onkoloji Bölümü Bat› Karadenizdeki tek kanser merkezidir. 2000 ila 2010 y›llar› aras›nda kad›nlarda meme kanserini retrospektif olarak araflt›rd›k. Çal›flmam›zdaki populasyonun ortalam yafl› 49.90 ± 12 'di ve ortalama takip süresi 4 ± 2 y›ld›.Hastalar›n yafla göre da¤›l›m›nda %25'ini 40 yafl ve alt›, %32'sini 40-50 yafl aras› oluflturmaktayken kalan %43'de 50 yafl ve üzeri hastalar oluflturmaktayd›.En s›k görülen kanser tipi 312 hastada saptanan invazif duktal karsinomdu (%80). Hastalar›n prognozuna bakt›¤›m›zda; 309 hasta(%80) hastal›ks›z sa¤kal›mda, 66 hastada (%17) progresyon, 7 hastada (%1,8) local nüks ve 15 hastada (%3,8) ölüm görüldü. Meme kanseri Bat› Karadeniz bölgesindeki kad›nlarda en s›k görülen solid organ tümörler-den olup prognostik faktörler ve ileri evre hastal›¤› olanlardada uzun yaflam beklentisi aç›s›ndan anlaml› bir fark saptanmad›. Hormonal pozitiflik ve tedavi uyumu bu duruma en önemli katk›y› sa¤lamaktayd›.

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“…Similarly, we interpret the similar number of CA repeats in both the metastatic and control groups as an adaptation of the tumor cells to the microenvironment. The primary factor affecting the prognosis of breast cancer is the status of metastasis (22). The most critical step for both regional and distant metastases is to traverse the extracellular matrix surrounding the tumor.…”

Section: Discussionmentioning

confidence: 99%

A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer

et al. 2013

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Th is paper concentrates on the Early Oligocene palaeoclimate of the southern part of Eastern and Central Europe and gives a detailed climatological analysis, combined with leaf-morphological studies and modelling of the palaeoatmospheric CO 2 level using stomatal and δ 13 C data. Climate data are calculated using the Coexistence Approach for Kiscellian fl oras of the Palaeogene Basin (Hungary and Slovenia) and coeval assemblages from Central and Southeastern Europe. Potential microclimatic or habitat variations are considered using morphometric analysis of fossil leaves from Hungarian, Slovenian and Italian fl oras. Reconstruction of CO 2 is performed by applying a recently introduced mechanistic model. Results of climate analysis indicate distinct latitudinal and longitudinal climate patterns for various variables which agree well with reconstructed palaeogeography and vegetation. Calculated climate variables in general suggest a warm and frost-free climate with low seasonal variation of temperature. A diff erence in temperature parameters is recorded between localities from Central and Southeastern Europe, manifested mainly in the mean temperature of the coldest month. Results of morphometric analysis suggest microclimatic or habitat diff erence among studied fl oras. Extending the scarce information available on atmospheric CO 2 levels during the Oligocene, we provide data for a well-defi ned time-interval. Reconstructed atmospheric CO 2 levels agree well with threshold values for Antarctic ice sheet growth suggested by recent modelling studies. Th e successful application of the mechanistic model for the reconstruction of atmospheric CO 2 levels raises new possibitities for future climate inference from macro-fl ora studies.

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The Natural History of Untreated Breast Cancer

Cited by 14 publications

References 3 publications

A clinico-pathological study of malignant breast lump in a tertiary care hospital in Kosi region of Bihar, India

A clinico-pathological study of malignant breast lump in a tertiary care hospital in Kosi region of Bihar, India

Retrospective Evaluation of the Female Patients with Breast Cancer: Western Black Sea Region, Unicentered, Clinical Data of Oncology

A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer

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