The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

Rangel‐Frausto, M. Sigfrido; Pittet, Didier; Costigan, Michele; Hwang, Tae Sik; Davis, Christine S.; Wenzel, Richard P.

doi:10.1001/jama.1995.03520260039030

Cited by 1,623 publications

(443 citation statements)

References 21 publications

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“…However, this is not surprising, as we studied only severely ill patients who had septic shock. Previous studies have shown that the severity of sepsis correlates with the incidence of kidney injury [4]. The incidence of acute kidney injury we report is substantially higher than the incidence in the most severely ill patients described by Rangel-Frausto et al [4], which may reflect between study differences due to case mix, or a true increased incidence of acute kidney injury in sepsis today compared with the past, as has been suggested by others [20].…”

Section: Incidence and Outcome Of Acute Kidney Injurysupporting

confidence: 53%

“…Previous studies have shown that the severity of sepsis correlates with the incidence of kidney injury [4]. The incidence of acute kidney injury we report is substantially higher than the incidence in the most severely ill patients described by Rangel-Frausto et al [4], which may reflect between study differences due to case mix, or a true increased incidence of acute kidney injury in sepsis today compared with the past, as has been suggested by others [20]. The high incidence we observed may also reflect greater sensitivity of the RIFLE definitions compared to older definitions of renal failure.…”

Section: Incidence and Outcome Of Acute Kidney Injurymentioning

confidence: 99%

“…The incidence ranges from 15-50% [2][3][4], and is associated with a mortality rate of 30-75% [2][3][4][5]. This variation in reported incidence and outcome is partly due to heterogeneous patients and different definitions of kidney injury used in these studies.…”

Section: Introductionmentioning

confidence: 99%

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The effects of vasopressin on acute kidney injury in septic shock

et al. 2009

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Kidney injury was present in 464 patients (59.6%) at study entry. In patients in the RIFLE "Risk" category (n=106) vasopressin as compared with norepinephrine was associated with a trend to a lower rate of progression to renal "Failure" or "Loss" categories (20.8% v 39.6% respectively, p=0.03), and a lower rate of use of renal replacement therapy (17.0% v 37.7%, p=0.02). Mortality rates in the "Risk" category patients treated with vasopressin compared to norepinephrine were 30.8% v 54.7%, p=0.01, but this did not reach significance in a multiple logistic regression analysis (OR=0.33, 99%CI 0.10-1.09, p=0.02). The interaction of treatment group and RIFLE category was significant in predicting mortality. Conclusions:Vasopressin may reduce progression to renal failure and mortality in patients at risk of kidney injury who have septic shock.

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Section: Incidence and Outcome Of Acute Kidney Injurysupporting

confidence: 53%

Section: Incidence and Outcome Of Acute Kidney Injurymentioning

confidence: 99%

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The effects of vasopressin on acute kidney injury in septic shock

et al. 2009

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“…Sepsis, severe sepsis, and septic shock are more frequent in the ICU than in other sections of a healthcare institution (22)(23)(24)(25). Several reports have confirmed that severe sepsis is found in 2% of patients admitted to the general ward, while it is found in up to 75% of ICU patients (18,20,26,27).…”

Section: Discussionmentioning

confidence: 98%

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

Ortíz¹,

Dueñas²,

Rodríguez

et al. 2013

biomedica

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“…Current understanding views death from multiorgan failure as the extreme consequence of stresses that induce a systemic inflammatory response syndrome (eg endotoxin, burns, mechanical trauma). [32][33][34] Evidence argues that the monocyte/macrophage system processes the inflammatory stimulus, 35,36 and then initiates and amplifies subsequent cytokine cascades. 37,38 Under certain conditions, this can lead to loss of control, functional immune paralysis, [39][40][41] or in the metaphor of Bone, 42 'immunologic dissonance'-a pathological imbalance between pro-and counter inflammatory molecules.…”

Section: Discussionmentioning

confidence: 99%

Psychological risk factors and early complications after bone marrow transplantation in adults

Szkrumelak

1999

Bone Marrow Transplant

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Summary:Complications of bone marrow transplantation can compromise its effectiveness, and often it is not possible to predict who is at greatest risk. In a previous study we reported that certain psychological factors correlated with a high incidence of post-transplant mortality, and here we analyze the associated complications and causes of death. Prior to receiving high-dose chemotherapy and bone marrow transplantation, 112 patients underwent a psychodynamically oriented psychiatric assessment (the 'FIT' assessment). Mortality and associated complications were ascertained by a retrospective chart review. The results of the 'FIT' assessment correlated with the incidence of complications and death, whether or not the transplant was performed for hematologic or solid organ cancers, or was from an allogeneic or autologous source. Most individuals with a high risk profile died of progressive major organ dysfunction or recurrent/refractory neoplastic disease in the first year after transplant. We propose that such a psychiatric assessment might identify a subgroup of individuals in whom pre-emptive therapeutic interventions could be most effective. Keywords: bone marrow transplantation; multiorgan failure; personality assessment; risk assessment; leukemia/lymphoma; cancer of breast and ovary Bone marrow transplantation can reverse the myelotoxicity of high-dose radiation and chemotherapy used in many current strategies to treat cancer. However, sepsis and hemorrhage before engraftment, acute and chronic graftversus-host disease, graft rejection, and late organ dysfunction still limit its effectiveness. 1 Thus, an understanding of predisposing factors that place an individual at risk for such difficulties might enable better control and prevention, and ultimately improve survival.Early in the development of clinical bone marrow transplantation, psychiatrists had recognized that family interactions, coping style, and meaning of the transplant had a profound impact on the individual, 2-5 but not until 1988

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The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

Abstract: This prospective epidemiologic study of SIRS and related conditions provides, to our knowledge, the first evidence of a clinical progression from SIRS to sepsis to severe sepsis and septic shock.

Cited by 1,623 publications

References 21 publications

The effects of vasopressin on acute kidney injury in septic shock

The effects of vasopressin on acute kidney injury in septic shock

Epidemiología de la sepsis en unidades de cuidado intensivo en Colombia

Psychological risk factors and early complications after bone marrow transplantation in adults

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