The Natural History of Simple Renal Cysts

Terada, Naoki; Ichioka, Kentaro; Matsuta, Yosuke; Okubo, Kazutoshi; Yoshimura, Koji; Arai, Yoichi

doi:10.1016/s0022-5347(05)65373-6

Cited by 194 publications

(132 citation statements)

References 7 publications

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“…Several authors reported patients whose hypertension was cured or significantly improved after surgery or percutaneous needle decompression of the cyst [4,[15][16][17][18]. As a pathogenetic mechanism, Lüscher et al [2] suggested that renal cysts may, by local tissue or renal arterial compression, induce local ischemia and in turn may activate the renin-angiotensin system, thus causing BP elevation.…”

Section: Discussionmentioning

confidence: 99%

Simple renal cysts and circadian blood pressure: are they related to each other in patients with hypertension?

et al. 2010

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Previous studies have shown that the presence of simple renal cysts was related to hypertension. However, the relationship between simple renal cysts and circadian blood pressure was not studied before. Our study population comprised of newly diagnosed patients with essential hypertension. Medical history, physical examination and office blood pressure measurements, laboratory analysis, ambulatory blood pressure measurements, renal ultrasonography, and 24-h urine specimens were collected. In total, the study included 190 patients (male/female ratio 77/113; mean age 50.3 ± 11.3). Overall, 127 (66.8%) patients were dippers and 92 (48.4%) had at least one simple renal cyst. Thirty-five patients had solitary cysts and 57 patients had multiple cysts. Cysts were bilateral in 47 of patients. Most of ambulatory blood pressure recordings were higher in patients with at least one simple cyst when compared to patients without cysts. In multivariate logistic regression analysis, serum uric acid (P: 0.047, OR: 1.287, CI: 1.011-1.658), lower creatinine clearance (P: 0.001, OR: 1.030, CI: 1.012-1.049), presence of diabetes (P: 0.029, OR: 2.451, CI: 1.094-5.491), and presence of at least one cyst in each kidney (P: 0.002, OR: 3.087, CI: 1.533-6.212) were found to be independently related to nocturnal non-dipping. In conclusion, the presence of simple renal cysts is related to higher ambulatory BP and is associated with non-dipping phenomenon in patients with essential hypertension.

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Section: Discussionmentioning

confidence: 99%

Simple renal cysts and circadian blood pressure: are they related to each other in patients with hypertension?

et al. 2010

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“…In one study, the incidence was 36% in mutation carriers versus 4.6-8.2% reported in general population [23,45,46]. Large and numerous kidney cysts were shown to develop also in a kidney-specific Fh1 knockout mouse model finally leading to polyuric renal failure.…”

Section: Renal Tumorsmentioning

confidence: 97%

Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics

2011

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Hereditary leiomyomatosis and renal cell cancer (HLRCC, also known as multiple cutaneous and uterine leiomyomatosis, MCUL) is a highly penetrant autosomal dominant tumor predisposition syndrome characterized by benign leiomyomas of the skin and the uterus. Renal cell carcinomas, occurring in a subset of the HLRCC families, are exceptionally aggressive. Therefore careful, frequent surveillance strategies are recommended. Association of malignant smooth-muscle tumors, leiomyosarcomas, with HLRCC has been observed but the risk appears to be smaller than initially estimated. To date inactivating heterozygous mutations in the fumarate hydratase (FH, fumarase) gene, predisposing to HLRCC, have been found in approximately 180 families worldwide. The most extensively studied hypothesis on molecular mechanisms of HLRCC tumorigenesis is activation of the hypoxia pathway due to aberrant stabilization of the HIF1 transcription factor. HIF1 regulates transcription of genes relevant for vascularization, glucose transport and glycolysis, processes that facilitate tumor growth. However, additional mechanisms underlying tumor formation are likely to exist.

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“…3 There also may be a weakening of the tubular basement membrane in the formation of the distal nephron diverticula. 6 …”

Section: Simple Renal Cystsmentioning

confidence: 99%

Diagnosis and Evaluation of Renal Cysts

Waterman

2014

Primary Care: Clinics in Office Practice

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The Natural History of Simple Renal Cysts

Cited by 194 publications

References 7 publications

Simple renal cysts and circadian blood pressure: are they related to each other in patients with hypertension?

Simple renal cysts and circadian blood pressure: are they related to each other in patients with hypertension?

Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics

Diagnosis and Evaluation of Renal Cysts

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