The Natural History of Psoriasis in 5,600 Patients

Abstract

The natural history of psoriasis was studied through a questionnaire survey of 5,600 patients throughout the United States. The mean age of onset of psoriasis was 27.8 years. 36% of the respondents reported familial occurrence of the disease. At the time of study, the lower extremities were indicated as being the most often affected; trunk, elbow, and scalp were next, knee and face were cited less frequently. Fingernails were involved in half of the patients at some time during the period of their disease. In the majority of patients, hot weather and sunlight had a beneficial effect. One third of the females also indicated improvement during the course of pregnancy. Remissions were reported in 39% of the patients.

Palmoplantar Psoriasis- Ahead in the Race-A Prospective Study from a Tertiary Health Care Centre in South India

“…Palmoplantar psoriasis is shown to constitute 3-4% of all psoriasis cases in most of the studies conducted [9]. Our study is first of its type done in South India to find the incidence of palmoplantar psoriasis and compare its incidence with other forms.…”

Susceptibility to psoriasis vulgaris is controlled in part by two unlinked genes in a double recessive manner

“…However, a much larger proportion (62 to 80~) is due to an apparent genetic heterogeneity on the susceptibility to PV. Some investigators favored a genetic heterogeneity in PV (Farber and Nall, 1974;Pietrzyk et al, 1982;Iselius and Williams, 1984;Henseler and Christophers, 1985). For this reason, several hypotheses have been proposed (Steinberg et al, 1952;Abele et al, 1963;Watson et al, 1972).…”

Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding

“…Psoriasis plaques with silvery scales present the Auspitz sign a pinpoint capillary bleeding when the scales are gently scraped away with a spatula or fingernail (Mrowietz, et al, 2007Naldi & Mercuri, 2010). Psoriasis may also attack nails, (Augustin et al, 2010b;Farber, & Nall , 1974), tendons, ligaments, fascia, and spinal or peripheral joints as the clinical form, inflammatory PsA similar to rheumatoid arthritis, but no rheumatoid factor present in the blood. PsA can be severely disabling, occurring in up to 10-30% of patients with psoriasis, and is associated with HLA-B27 MHC Class I marker (Mrowietz et al, 2007).…”