The Natural History of Peyronie's Disease

Maida, Fabrizio Di; Cito, Gianmartin; Lambertini, Luca; Valastro, Francesca; Morelli, Girolamo; Mari, Andrea; Carini, Marco; Cocci, Andrea

doi:10.5534/wjmh.200065

Cited by 33 publications

(17 citation statements)

References 46 publications

(62 reference statements)

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“…Assessing PD's effects on mental health and sexual functioning is pertinent to achieving preventive treatment goals, thus enhancing patients' well-being. As in much of the previous research [29], this study's findings showed that PD's impacts on mental health and sexual functioning are multi-dimensional and are not necessarily associated with penile curvature. In fact, most study participants had less severe penile curvature, and it is possible that other factors may interfere with PD's potential influence on sexual functioning and mental health, namely relationship issues, sexual performance anxiety, stigmatization, and isolation [19], which could lead to changes in perceptions concerning the true impacts of PD [21].…”

Section: Discussionsupporting

confidence: 63%

The impact of Peyronie's disease on Portuguese men's mental health and sexual functioning

2021

JOMH

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Purpose: The purpose of this study was to assess the impact of Peyronie's disease (PD) on Portuguese men's mental health and sexual functioning. Materials and Methods: Study participants included 103 men diagnosed with PD who had attended urology appointments at two hospitals in Portugal. The participants' average age was 34.38 years old (SD = 13.77). The study utilized a variety of measurement instruments, encompassing a sociodemographic questionnaire, the Portuguese version of the Brief Symptoms Inventory-18, the Portuguese version of the Massachusetts General Hospital-Sexual Functioning Questionnaire, and a Questionnaire measuring PD concerns. Results: Overall results showed that the men surveyed presented higher levels of mental health symptoms (somatization, depression, and anxiety) and lower levels of sexual functioning than the community sample (the general Portuguese population without clinical disorders). Correlation coeﬃcients showed a strong and positive correlation between mental health symptoms and a loss of sexual conﬁdence and stress, while ﬁnding a strong and negative correlation between sexual functioning and stress. Most PD concerns exhibited strong and positive mutual correlations. The study also found strong and positive correlations between penile curvature and a perceived reduction in penis attractiveness and discrimination fears. Multiple regression analyses showed that PD concerns and penile curvature explained 34.3% of the overall mental health variance and 21% of the overall sexual functioning variance. Conclusions: These results are consistent with those of previous studies that have shown that experiencing PD can increase mental health symptoms and diminish sexual functioning.

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Section: Discussionsupporting

confidence: 63%

The impact of Peyronie's disease on Portuguese men's mental health and sexual functioning

2021

JOMH

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“…The acute phase is typified by progressive changes in penile morphology and the presence of erectile pain. The chronic phase is generally defined by stability in penile morphology for at least three months, as well as absence of erectile discomfort (13,14). The duration of the acute phase varies in the literature, although it is commonly accepted to last up to 12-18 months (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Intralesional collagenase Clostridium histolyticum for acute phase Peyronie’s disease: a single-center, retrospective cohort study

Hu¹,

Sigalos²,

Walker³

et al. 2022

Transl Androl Urol

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Background: Peyronie's disease (PD) can be subdivided into acute and chronic phases. Intralesional collagenase Clostridium histolyticum has been shown to improve curvature in the chronic phase. Initial clinical trials excluded patients in the acute phase from treatment. Recent studies show comparable results among men in the acute phase. The definition of acute phase varies among existing studies, but it is generally understood to last 12-18 months and is accompanied by penile pain and progression of deformity. We sought to evaluate the safety and efficacy of intralesional collagenase injection therapy during the acute phase of PD using multiple definitions of the acute phase.Methods: All men receiving intralesional collagenase for PD from October 2015 through December 2020 at a single academic institution were retrospectively assessed for patient demographics and comorbidities, pre-and post-treatment curvature, and adverse events. Two definitions of acute phase were used: (I) acute phase duration ≤6 months, chronic phase duration >6 months; and (II) acute phase duration ≤12 months with penile pain, chronic phase duration >12 or no penile pain.Results: Of 330 patients identified, 229 underwent intralesional collagenase treatment with pre-and post-treatment erect penile goniometry. 65 (28%) met criteria for definition 1 of acute phase, 37 (16%) met criteria for definition 2, and 76 (33%) met criteria for either. Percent change in penile curvature was not significantly different between acute and chronic phases using definition 1 (16.0% vs. 16.6%, P=0.89), definition 2 (19.9% vs. 15.7%, P=0.43), or either (16.5% vs. 16.3%, P=0.96). The rates of development of bruising, swelling, hematoma, or corporal rupture were not significantly different between the acute and chronic phases under either definition (all P>0.05).Conclusions: This single-center, retrospective cohort analysis suggests that intralesional collagenase is both safe and effective for the treatment of men with acute phase PD. Limitations exist inherent to retrospective review, since many men did not return for post-treatment goniometry, possibly skewing our cohort toward incomplete responders. Prospective, randomized studies will be required to confirm these findings.

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“…Plaque formation generally occurs during the acute phase, whereas during chronic phase pain usually tends to complete resolution and penile deformity stabilizes. PD’s pathophysiology is still subject of great discussion ( Di Maida et al, 2021 ). In addition, according to valid evidence, after bilateral cavernous nerve injury (BCNI), increased expression and activity of penile lysyl oxidase (LOX) could be detected, which promoted penile fibrosis, reduced SMC content, and induced ED ( Wan et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics-Based Identification of Potential Hypoxia-Related Genes Associated With Peyronie’s Disease

et al. 2022

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Hypoxia is one of the most important predisposing conditions for Peyronie’s disease (PD) and the pathogenetic mechanism is yet to be completely elucidated. This study applied bioinformatic approaches to select candidate hypoxia-related genes involved in the pathogenesis of PD. The Gene Expression Omnibus (GEO) data set GSE146500 was introduced to compare the transcriptional profiling between normal and PD samples. The differential expression of hypoxia-related gene was determined with R software. On the selected candidate genes, further functional analyses were applied, including protein–protein interactions (PPIs), gene correlation, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. A total of 66 candidate genes (24 candidates overexpressed in PD and 42 showing reduced expression in PD) were distinguished according to the differential expression between human fibroblast cells from normal and PD patients. The interactions among these candidate genes were recognized according to PPI analysis. The functional enrichment analyses revealed the potential modulatory functions of the candidate genes in some major biological processes, especially in glycolysis/gluconeogenesis and carbon metabolism. The findings would facilitate further study on the pathogenesis of PD, which might consequently promote the improvement of clinical strategies against PD.

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The Natural History of Peyronie's Disease

Cited by 33 publications

References 46 publications

The impact of Peyronie's disease on Portuguese men's mental health and sexual functioning

The impact of Peyronie's disease on Portuguese men's mental health and sexual functioning

Intralesional collagenase Clostridium histolyticum for acute phase Peyronie’s disease: a single-center, retrospective cohort study

Bioinformatics-Based Identification of Potential Hypoxia-Related Genes Associated With Peyronie’s Disease

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