The Natural History of Pediatric Ulcerative Colitis: A Population-Based Cohort Study

Abstract

Pediatric UC was characterized by widespread localization at diagnosis and a high rate of disease extension. Twenty percent of children had their colon removed after 5 years. The colectomy rate was influenced by disease extension and was associated with the presence of EIMS at diagnosis.

Systematic analysis of factors associated with progression and regression of ulcerative colitis in 918 patients

“…9 In the process of analysis of data on paediatric UC patients, a family history of IBD was identified as a risk factor for disease progression. 16 We were unable to confirm these findings in our study of adult UC patients. In the course of literature search, we did not find any studies that evaluated factors associated with disease regression.…”

“…At diagnosis, UC patients presented with the following disease extent: proctitis [199 patients (21.7%)], left-sided colitis [338 patients (36.8%)] and extensive colitis/pancolitis [381 (41.5%)]. During a median disease duration of 9 [4][5][6][7][8][9][10][11][12][13][14][15][16] years, progression and regression was documented in 145 patients (15.8%) and 149 patients (16.2%) respectively. In addition, 624 patients (68.0%) had a stable disease extent.…”

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

“…Gower-Rousseau et al 21 reported that a delay of more than 6 months in diagnosis was associated with an increased risk of extensive disease.…”

Incidence and Phenotype at Diagnosis of Very-early-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease: A Population-based Study [1988–2011]

“…The phenotype of children with VEO-IBD is loosely defined but is usually considered as being more severe than when diagnosed later in life. [17][18] However, most published studies have not been population based but covered patients followed in referral centres, and the incidence and natural history of VEO-IBD are still poorly understood.…”