The Natural History of Idiopathic Scoliosis During Growth

Felice, Francesca Di; Zaina, Fabio; Donzelli, Sabrina; Négrini, Stefano

doi:10.1097/phm.0000000000000861

Cited by 28 publications

(26 citation statements)

References 21 publications

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“…Rate of scoliosis progression was 65 % in this study, since 36 progressive patients out of 55. A recent meta-analysis by Di Felice et al [17] reported a progression rate of 49%, with a large 95% confidence interval of 19%-79%. The present study falls within the higher spectrum of this confidence interval, while the study by Danielsson et al [15] falls on the lower part of the spectrum, with a 40% progression rate.…”

Section: Discussionmentioning

confidence: 99%

“…Part of this cohort (thirty patients) was already used in the previous validation work [13], but some patients were imaged with older stereoradiographic devices with low image quality; these patients were excluded from the current study. Cohort size for this sensitivity/specificity study was defined based on the hypothesis of 40 % prevalence for progressive AIS [15][16][17] and a statistical power of 0.8 [18], leading to a minimal cohort of 50 patients with at least 20 progressive cases.…”

Section: Subjectsmentioning

confidence: 99%

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Quasi-automatic early detection of progressive idiopathic scoliosis from biplanar radiography: a preliminary validation

et al. 2019

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Purpose To validate the predictive power and reliability of a novel quasi-automatic method to calculate the severity index of adolescent idiopathic scoliosis (AIS). Methods Fifty-five AIS patients were prospectively included (Age: 10-15, Cobb: 16° ± 4°). Patients underwent low-dose biplanar x-rays and a novel fast method for 3D reconstruction of the spine was performed. They were followed until skeletal maturity (stable patients) or brace prescription (progressive patients). The severity index was calculated at the first exam, based on 3D parameters of the scoliotic curve, and it was compared with the patient's final outcome (progressive or stable). Three operators have repeated the 3D reconstruction twice for a subset of 30 patients to assess reproducibility (through Cohen's kappa and intraclass correlation coefficient). Results 85% of the patients were correctly classified as stable or progressive by the severity index, with a sensitivity of 92% and specificity of 74%. Substantial intra-operator agreement and good inter-operator agreement were observed, with 80% of the progressive patients correctly detected at the first exam. The novel severity index assessment took less than 4 minutes of operator time. Conclusions The fast and semi-automatic method for 3D reconstruction developed in this work allowed for a fast and reliable calculation of the severity index. The method is fast and user friendly. Once extensively validated, this severity index could allow very early initiation of conservative treatment for progressive patients, thus increasing treatment efficacy and therefore reducing the need for corrective surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Quasi-automatic early detection of progressive idiopathic scoliosis from biplanar radiography: a preliminary validation

et al. 2019

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“…Furthermore, the progression of scoliosis curve severity was analyzed by measuring the Cobb angle on the first and last radiograph available for each patient with at least one year of follow-up. A progressive curve was defined as at least a 5° increase over the follow-up period [ 24 ]. Additionally, if a patient had received brace treatment or surgery, the curve was considered progressive.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, if a patient had received brace treatment or surgery, the curve was considered progressive. Of all 22q11.2DS patients with progressive scoliosis, the curve progression rate in degrees of Cobb angle per year was calculated and compared to reference values of idiopathic scoliosis in the general population, as described in a meta-analysis by Di Felice et al in 2018 [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

22q11.2 Deletion Syndrome as a Human Model for Idiopathic Scoliosis

Reuver

Homans

Schlösser

et al. 2021

JCM

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To better understand the etiology of idiopathic scoliosis, prospective research into the pre-scoliotic state is required, but this research is practically impossible to carry out in the general population. The use of ‘models’, such as idiopathic-like scoliosis established in genetically modified animals, may elucidate certain elements, but their translatability to the human situation is questionable. The 22q11.2 deletion syndrome (22q11.2DS), with a 20-fold increased risk of developing scoliosis, may be a valuable and more relevant alternative and serve as a human ‘model’ for idiopathic scoliosis. This multicenter study investigates the morphology, dynamic behavior, and presence of intraspinal anomalies in patients with 22q11.2DS and scoliosis compared to idiopathic scoliosis. Scoliosis patients with 22q11.2DS and spinal radiography (n = 185) or MRI (n = 38) were included (mean age 11.6 ± 4.2; median Cobb angle 16°) and compared to idiopathic scoliosis patients from recent literature. Radiographic analysis revealed that 98.4% of 22q11.2DS patients with scoliosis had a curve morphology following predefined criteria for idiopathic curves: eight or fewer vertebrae, an S-shape and no inclusion of the lowest lumbar vertebrae. Furthermore, curve progression was present in 54.2%, with a mean progression rate of 2.5°/year, similar to reports on idiopathic scoliosis with 49% and 2.2–9.6°/year. The prevalence of intraspinal anomalies on MRI was 10.5% in 22q11.2DS, which is also comparable to 11.4% reported for idiopathic scoliosis. This indicates that 22q11.2DS may be a good model for prospective studies to better understand the etiology of idiopathic scoliosis.

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“…Только при I-II степени искривления консервативное лечение является эффективным [17]. В большом проценте случаев идиопатический сколиоз имеет тенденцию прогрессировать в периоды интенсивного роста [18]. При прогрессировании деформации даже соблюдение всех необходимых условий консервативного лечения не позволяет устранить искривление позвоночника.…”

Section: лечение сколиотической болезниunclassified

Idiopathic scoliosis: general characteristics and analysis of etiological theories (literature review)

Строкова

Pahomova

Gusev

et al. 2021

Acta biomedica scientifica

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Idiopathic scoliosis is a severe pathology of the musculoskeletal system that affects children and adolescents all over the world. The disease occurs in approximately 0.2-0.6% of the general population, and is the largest subgroup of spinal curvature in humans (70-90% of all known scoliosis cases). In idiopathic scoliosis, a threedimensional deformation of the vertebral column is formed, leading to the formation of a rib hump, curvature of the ribs and chest, asymmetry of the pelvis and impaired development of internal organs. The main feature of the disease is the spontaneous development of deformity during the growth of the child and the tendency to progress. Scoliosis is not only an orthopedic disease, but also a ignificant cosmetic, and, consequently, a psychological and social problem. The standard of treatment for scoliotic disease remains unchanged for a long time: observation, corset treatment and surgical correction. The prognosis for the development of pathology varies depending on the degree of deformation. The corset-therapy, hospitalization, surgery and treatment of chronic back pain have a negative impact on the psychoemotional state of children and adolescents. Despite significant advances in the methods of diagnosis of deformity, improvement of surgical treatment methods and in the study of pathogenesis, the etiological factor of pathology is still unknown. The search for the causes of idiopathic scoliosis covers almost all aspects of its possible origin: genetic, environmental, hormonal, metabolic, biochemical, neurological, and others. In recent decades, relevant theories of the development of scoliosis have been formulated, but none of the theories reveals the essence of the pathological process and has no clear justification. The greatest number of supporters is the genetic theory: genetic factors play a key role in the occurrence and development of idiopathic scoliosis. Understanding the underlying factors of the disease will enable prevention, early diagnosis, and identification of the risk groups of the patients in question.

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The Natural History of Idiopathic Scoliosis During Growth

Cited by 28 publications

References 21 publications

Quasi-automatic early detection of progressive idiopathic scoliosis from biplanar radiography: a preliminary validation

Quasi-automatic early detection of progressive idiopathic scoliosis from biplanar radiography: a preliminary validation

22q11.2 Deletion Syndrome as a Human Model for Idiopathic Scoliosis

Idiopathic scoliosis: general characteristics and analysis of etiological theories (literature review)

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