The natural history of idiopathic dilated cardiomyopathy

Fuster, Valentı́n; Gersh, Bernard J.; Giuliani, Emilio R.; Tajik, A. Jamil; Brandenburg, Robert O.; Frye, Robert L.

doi:10.1016/0002-9149(81)90534-8

Cited by 902 publications

(261 citation statements)

References 41 publications

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“…[1][2][3][4] Dilated cardiomyopathy is a primary cause of severe heart failure with subsequent transplantation or death within several years after diagnosis. 1,5 The direct result of cellular infiltration of the myocardium is necrosis and loss of myocytes leading to the development of contractile dysfunction and ventricular dilatation. The loss of myocytes and formation of scar tissue in the myocardium would lead to loss of contractile function and ventricular enlargement.…”

mentioning

confidence: 99%

Cardiac Myosin and the TH1/TH2 Paradigm in Autoimmune Myocarditis

Cunningham

2001

The American Journal of Pathology

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confidence: 99%

Cardiac Myosin and the TH1/TH2 Paradigm in Autoimmune Myocarditis

Cunningham

2001

The American Journal of Pathology

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“…Heart failure is associated with activation of the sympathetic nervous system and electrolyte abnormalities that could affect arrhythmogenesis.122,24 In addition, heart failure patients are predisposed to systemic and venous thromboemboli that could precipitate cardiac arrest. 25 Establishing the causes of cardiac arrest in heart failure patients is important for the development of therapeutic strategies to reduce sudden death in this population. Therefore, we reviewed clinical and autopsy data from all electrocardiographically monitored, sudden, unexpected cardiac arrests observed during a 4-year period in hospitalized patients with advanced but stable heart failure.…”

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Diverse mechanisms of unexpected cardiac arrest in advanced heart failure.

Luu¹,

Stevenson²,

Stevenson³

et al. 1989

Circulation

483

154

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To define the mechanisms of unexpected cardiac arrest in advanced heart failure, we reviewed the causes of cardiac arrest as established from electrocardiographic monitoring and from clinical and autopsy data in patients hospitalized for cardiac transplantation evaluation and management of advanced heart failure (mean left ventricular ejection fraction, 0.18 +/- 0.08) who were stable while on vasodilator and diuretic therapy such that hospital discharge to home was anticipated. Twenty-one cardiac arrests occurred in 20 of 216 (9%) such patients during a 4-year period. Heart failure was due to coronary artery disease with prior myocardial infarction in 13 patients and nonischemic cardiomyopathy in seven patients. The rhythm at the time of arrest was severe bradycardia or electromechanical dissociation (BA/EMD) in 13 (62%) patients. The precipitating cause of the BA/EMD arrest was coronary artery thrombosis or embolism in two patients, pulmonary embolism in one patient, hyperkalemia in two patients, and unexplained hypoglycemia in one patient. In seven of 13 (54%) patients, a precipitating cause of the bradycardia arrest could not be established. Only eight of 21 (38%) arrests were due to ventricular tachycardia or fibrillation (VT/VF), and all occurred in patients with prior myocardial infarction (p = 0.02 vs. BA/EMD arrests). Two VT/VF arrests were due to acute or recent infarction, and one patient had hyperkalemia. The patients who suffered a BA/EMD arrest were similar to those who had a VT/VF arrest in age, ventricular arrhythmia history, ventricular function, and serum potassium levels. Serum sodium levels were lower in patients with BA/EMD arrests (129 +/- 3 vs. 133 +/- 4 meq/l, p = 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Dilated cardiomyopathy is a disease that carries a poor prognosis and for which no radical therapy is available (Report of the WHO 1980; Fuster et al 1981). Its aetiology is unknown at present, but various factors are thought to be involved.…”

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confidence: 99%

Natural killer cells in dilated cardiomyopathy.

Yokoyama

1988

Tohoku J. Exp. Med.

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The natural history of idiopathic dilated cardiomyopathy

Cited by 902 publications

References 41 publications

Cardiac Myosin and the TH1/TH2 Paradigm in Autoimmune Myocarditis

Cardiac Myosin and the TH1/TH2 Paradigm in Autoimmune Myocarditis

Diverse mechanisms of unexpected cardiac arrest in advanced heart failure.

Natural killer cells in dilated cardiomyopathy.

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