The natural history of <i>nevus sebaceus</i>

Morioka, Sadao

doi:10.1111/j.1600-0560.1985.tb01623.x

Cited by 83 publications

(38 citation statements)

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“…Childhood onset of BCC has previously been associated with albinism, 21,27 Bazex syndrome, 21,28 BCC nevus syndrome, 25,26,[29][30][31][32][33]53 nevus sebaceous, 2,25,26,[34][35][36][37][38][39][40] solid organ transplants, 47,48 xeroderma pigmentosum, 25,29,32,[49][50][51][52] and radiotherapy-treated cancers, such as astrocytoma, 44 ependymoma, 41 hemangioma, 26 Hodgkin lymphoma, 38,46 leukemia, 38,[42][43][44][45][46] medulloblastoma, 22,29,33,46 neuroblastoma, 38 optic nerve glioma, 41 and unspecified malignant tumor. 32 Children are defined to be 18 y...…”

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confidence: 99%

Basal cell carcinoma in childhood: Case report and literature review

Griffin¹,

Cohen²,

Tschen³

et al. 2007

Journal of the American Academy of Dermatology

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confidence: 99%

Basal cell carcinoma in childhood: Case report and literature review

Griffin¹,

Cohen²,

Tschen³

et al. 2007

Journal of the American Academy of Dermatology

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“…During puberty, they usually enlarge and become elevated, verrucous, or nodular and may appear brown (1,2). In late childhood and adulthood, there is a significant risk of developing a secondary tumor, the most common of which are syringocystadenoma papilliferum and basal cell carcinoma (1,3).…”

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confidence: 99%

The Role of Androgen Receptors in the Clinical Course of Nevus Sebaceus of Jadassohn

2001

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Nevus sebaceus of Jadassohn (NSJ) is a benign, congenital hamartoma that often presents at birth, appears to regress in childhood, and grows during puberty, suggesting possible hormonal control. We studied 18 cases of NSJ from children and adults for immunohistochemical evidence of androgen receptor expression. The lesions were evaluated for location and pattern of immunostaining, and these findings were compared between age groups, sexes, and to androgen receptor expression in normal skin. Androgen receptor positivity was seen in the sebaceous glands, in eccrine glands with and without apocrine change, and rarely in keratinocytes in the sebaceous nevi. There were no significant differences in staining location or pattern between the age groups or sexes. Normal skin showed similar staining in the sebaceous glands but did not show staining of the eccrine glands or keratinocytes. Androgen receptors are present in all epithelial components of NSJ, but there is no change in androgen receptor expression during puberty.

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“…3,[5][6][7][8] The necessity of early surgical excision was first questioned as a result of a 1995 study by Chun et al that documented nine benign tumors (5.5 percent) in 165 patients with nevus sebaceus and no patients (0 percent) with malignant transformation. 13 This finding has since been confirmed by several other large, retrospective studies that demonstrate an incidence of only 6.1 and 0.5 percent, respectively, for benign and malignant tumor development.…”

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confidence: 99%