The natural history of group B streptococcal colonization in the pregnant woman and her offspring

Yow, Martha D.; Leeds, Leroy J.; Thompson, Peter; Mason, Edward O.; Clark, Dorothy J.; Beachler, Craig W.

doi:10.1016/0002-9378(80)90382-8

Cited by 100 publications

(58 citation statements)

References 11 publications

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“…Yow et al [14], Kubota [23] and others [15,25] performed only vaginal or cervicovaginal swabs and found prevalences between 6% and 14.2%, whereas rectovaginal cultures done in several other studies [3,8,16,21,24,26] revealed higher rates between 19.4% and 31%, similar to the 21% found in our study. Since vaginal and in particular rectal flora contains numerous micro-organisms, the use of selective enrichment broth is recommended to maximise the isolation of GBS and to avoid the overgrowth of other organisms.…”

Section: Commentsupporting

confidence: 87%

“…In various studies [27,29,35,36] no significant differences in colonisation rates were noted on the basis of age or parity, but increasing age [5] and parity [5,14] have also sometimes been associated with lower rates of carriage. However, Regan et al [2] described GBS carriage as being more common among older women and women of lower parity.…”

Section: Commentmentioning

confidence: 99%

“…In previous studies, GBS carriage prevalences between 1.6% and 30.4% have been described [2][3][4][5]7,8,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The differences in these prevalences can probably be explained by the different gestational ages at culturing, differences in culture site and in the use of different culture techniques.…”

Section: Commentmentioning

confidence: 99%

“…Discordant results are reported regarding the effects of age and parity on GBS prevalence [5,14,27,28,33,34]. In various studies [27,29,35,36] no significant differences in colonisation rates were noted on the basis of age or parity, but increasing age [5] and parity [5,14] have also sometimes been associated with lower rates of carriage.…”

Section: Commentmentioning

confidence: 99%

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Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Berg

Sprij

Oostvogel³

et al. 2006

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: This study was performed to determine the prevalence of GBS and to identify GBS colonisation risk factors in a multicultural population of pregnant women in The Netherlands. We calculated predictive values of cultures in pregnancy for intrapartum GBS carriage. Study design: From a total of 1702 women visiting several antenatal outpatient departments, rectovaginal swabs were collected at 35-37 weeks' gestation. In 761 women swabs were repeated at time of delivery. Carriage of GBS late in third trimester and at time of delivery was analysed in relation to age, parity, ethnicity and socio-economic status. Results: Twenty-one percent was GBS carrier late in pregnancy. Compared to Europeans, African women were at a higher risk (29%, RR 1.4, CI 1.1-1.7) and Asian women were at lower risk (13%, RR 0.6, CI 0.4-0.8) for GBS carriage. No differences in colonisation were found between women with respect to age, parity or socio-economic background. Positive predictive value of GBS carriage at 35-37 weeks' gestation for carriage at time of parturition was 79% and negative predictive value was 93%. Conclusions: It was not possible to identify a group of pregnant women at high risk for GBS colonisation. Predictive values of antenatal genital group B streptococci cultures at 35-37 weeks' gestation for intrapartum GBS carriage are lower than previously reported. # 2005 Published by Elsevier Ireland Ltd.

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Section: Commentsupporting

confidence: 87%

Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

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Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Berg

Sprij

Oostvogel³

et al. 2006

European Journal of Obstetrics & Gynecology and Reproductiv

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“…The primary source of infection in the neonate is the colonized maternal birth canal, with transmission occurring before or during the birth process. Estimates of GBS colonization rates in pregnant women range from 12% to 35% (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Forty per cent to 75% of infants born to colonized mothers are born colonized (18).…”

mentioning

confidence: 99%

The Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of neonatal group B streptococcal infections in Canada

Davies

LeBlanc

Bortolussi

et al. 1999

Paediatrics &Amp; Child Health

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OBJECTIVES:To determine the presentation and medical outcomes of neonatal group B streptococcus (GBS) disease in Canada, and describe maternal and obstetrical risk factors. DESIGN: Retrospective review of health records and laboratory databases using standardized data collection forms. SETTING: All neonates diagnosed with GBS infections in 1992 at 13 Canadian paediatric centres. RESULTS: A total of 105 infants meeting the criteria for neonatal GBS disease were identified. The majority of cases (78 or 74.3%) had earlyonset disease (EOD); 78.9% (60 of 76) of these cases presented within 24 h of delivery. Rates of EOD (less than seven days) varied from 0.44/1000 live births to 2.1/1000 live births, with an overall rate of 1.2/1000 live births. Pneumonia was the most common clinical illness (43.8%), followed by bacteremia without focus (23.8%) and meningitis (16.2%). At least one maternal risk factor for neonatal GBS disease was noted in 46 of 78 (59%) infants with EOD. A median of one dose (range one to 23 doses) of intrapartum antibiotics was given in 18 of 75 (24%) of the pregnancies. Overall, the mean gestational age at birth was 36.2±4.7 weeks, with 38 of 96 (39.6%) infants having a gestational age at birth younger than 37 weeks (31 of 73 [42.5%] EOD cases were born with a gestational age younger than 37 weeks). The median birth weight was 3099 g (range 610 g to 4830 g). Thirty of 94 (31.9%) infants had a birth weight less than 2500 g. Seventeen (16.2%) infants died. CONCLUSIONS: In 1992, neonatal GBS disease was a significant cause of morbidity and mortality in Canadian infants. More than half of the cases identified in this study could have been potentially preventable by the use of intrapartum antibiotics for women with known risk factors. There is a need for prospective studies to better define risk factors and preventative measures for neonatal GBS infections in Canada.

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Group B Streptococcal Sepsis in Adults and Infants

Opal

Cross²,

Palmer³

et al. 1988

Arch Intern Med

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The natural history of group B streptococcal colonization in the pregnant woman and her offspring

Cited by 100 publications

References 11 publications

Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

Prevalence of colonisation with group B Streptococci in pregnant women of a multi-ethnic population in The Netherlands

The Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of neonatal group B streptococcal infections in Canada

Group B Streptococcal Sepsis in Adults and Infants

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