The Natural History of Genital Herpes Simplex Virus

Corey, Lawrence

doi:10.1007/978-1-4615-8021-8_1

Cited by 7 publications

(6 citation statements)

References 110 publications

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“…Thirty sera from blood donors, confirmed to be seronegative by ELISA using HSV whole antigens [Hashido et al, 1989] were also examined. The clinical types of genital herpes [Nahmias et al, 1970;Corey, 1985] of the patients from whom serum was collected were as follows; panel A consisted of 10 cases of primary, 3 cases of recurrent and 4 cases of nonprimary first episode type HSV-1 genital herpes, panel B consisted of 9 primary and 9 recurrent cases of HSV-2 genital herpes, and panel C consisted of 11 recurrent and 8 nonprimary first episode cases of HSV-2 genital herpes. The primary type was diagnosed if HSV neutralizing antibody titer in the acute-phase serum was <8.…”

Section: Methodsmentioning

confidence: 99%

Detection of herpes simplex virus type-specific antibodies by an enzyme-linked immunosorbent assay based on glycoprotein G

et al. 1997

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In order to develop a simple and quantitative method to detect herpes simplex virus (HSV) type-specific antibodies, the usefulness of an enzyme-linked immunosorbent assay (ELISA) using HSV glycoprotein G (gG) captured on a plate by monoclonal antibodies as antigen was studied. The gG1- and gG2-specific IgG antibody activities were measured by the ELISA for 54 sera which had been collected from culture-proven genital herpes patients and pre-characterized by an immunodot assay using purified gG antigens. Thirty control sera without antibodies against the HSV whole antigens were also included. In comparison with the immunodot assay as standard, the sensitivities of the ELISA were 88.9% (32/36) for HSV-1 antibody and 89.2% (33/37) for HSV-2 antibody and the specificities were both 100%. Sera taken within a few months after primary infection tended to give false negative results. The HSV type-specific ELISA based on easy-to-prepare gG antigens might be useful to help improve the serological assessment of HSV infections.

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Section: Methodsmentioning

confidence: 99%

Detection of herpes simplex virus type-specific antibodies by an enzyme-linked immunosorbent assay based on glycoprotein G

et al. 1997

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“…Physicians in most European countries perceive patients to have a very low level of understanding of GH, chlamydia and other sexually transmitted diseases (STDs). This perception is supported by a survey on the public awareness of GH (International Herpes Management Forum 1997) 3 where only 17% of the general public in the USA were aware of the disease. The management of GH is further complicated by the opinion, held by 20% of physicians in one US survey, that GH is a trivial disease 3 .…”

Section: Herpes Awareness In the General Public And Physiciansmentioning

confidence: 96%

“…This perception is supported by a survey on the public awareness of GH (International Herpes Management Forum 1997) 3 where only 17% of the general public in the USA were aware of the disease. The management of GH is further complicated by the opinion, held by 20% of physicians in one US survey, that GH is a trivial disease 3 . What physicians ignore, however, is the significant negative psychological impact that GH can have on an infected patient.…”

Section: Herpes Awareness In the General Public And Physiciansmentioning

confidence: 96%

“…It should be noted that there is a lack of comparative evidence to support the necessity of these higher dosing regimens. The main concern for physicians is that when the daily treatment course is stopped (for more than a few days) the rate of recurrences resumes at the pretreatment level 3 . Physicians do not want to have patients dependent on tablets.…”

Section: Efficacy Of Current Treatmentmentioning

confidence: 99%

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Current treatments and perceptions of genital herpes: a European‐wide view

Strand

Barton

Alomar³

et al. 2002

Acad Dermatol Venereol

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A European panel of physicians reviewed the current treatments and perceptions of recurrent genital herpes (GH) across the continent. The panel consisted of specialists in dermatology and venereology from France, Finland, Germany, Italy, Norway, Spain, Sweden and the UK. A wide variety of factors that influence GH management were considered, including different health delivery systems, funding and cultural differences. The poor awareness of GH among both the general public and physicians was highlighted. The effectiveness of GH management was then examined from a patient's viewpoint, including the confirmation of the diagnosis, information and counselling about GH, as well as prescriptions for treatment. It was agreed that both physicians and patients often feel uncomfortable about discussing the disease, and that a European-wide effort is needed to re-educate patients and physicians about GH. The panel identified clear and unmet needs to manage a patient with clinical recurrences and to attempt to reduce the risk of GH transmission. Finally, resiquimod, an immune response modifier, was considered as a potential treatment option for GH.

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“…Most of the initial infections of HSV-1 were acquired in early childhood, usually from a close relative kissing the child when an active coldsore was present (Corey, 1982). All of the herpes simplex viruses (both HSV-1 and HSV-2) are transmitted through direct physical contact either with physical touching (autoinoculation can result from transferring the virus to another part of one's body from the original site of .infection), kissing, or sexual intercourse.…”

Section: Introduction and Literature Reviewmentioning

confidence: 99%

The psychological intervention of group therapy for women coping with genital herpes

Ferguson¹

2000

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H;nayna;(j _ / ---Three groups of women who had been diagnosed as having genital herpes completed a series of psychological assessments over the course of the four-month research period. One group received t.-10-hour weekly group psychotherapy sessions for eight consecutive weeks as a mode of treatment intervention. Two control groups were used '> fo1~ efficacy of treatment compar~ son. One control group consisted of regular members of a local self~help chapter for herpes victims.The second control group was formed from those volunteers willing to participate, but who did not choose, or desire, any form of treatment, Outcome measures reflected a greater improvement in psychological adjustment following group therapy for the treatment group on depression, anxiety, and physical self-esteem as compared to the two control groups. Implications from the findings of this mode of therapy for genital herpes victims are reviewed and discussed.

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The Natural History of Genital Herpes Simplex Virus

Cited by 7 publications

References 110 publications

Detection of herpes simplex virus type-specific antibodies by an enzyme-linked immunosorbent assay based on glycoprotein G

Detection of herpes simplex virus type-specific antibodies by an enzyme-linked immunosorbent assay based on glycoprotein G

Current treatments and perceptions of genital herpes: a European‐wide view

The psychological intervention of group therapy for women coping with genital herpes

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