The natural history of ductal carcinoma in situ of the breast: a review

Erbas, Bircan; Provenzano, Elena; Armes, Jane E.; Gertig, Dorota M.

doi:10.1007/s10549-005-9101-z

Cited by 320 publications

(243 citation statements)

References 88 publications

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“…Firstly, as DCIS is commonly detected asymptomatically it is often unanticipated (Hamilton, 1992) and the majority of women are unaware that the condition exists (Schwartz et al, 2000;Prinjha et al, 2006). The natural history of DCIS remains poorly understood because most patients receive surgery (Erbas et al, 2006); currently therefore it is difficult to accurately predict the risk of developing invasive breast cancer with or without treatment. Treatment options for DCIS are also controversial but involve surgery, possibly radiotherapy and hormone therapy.…”

Section: Introductionmentioning

confidence: 99%

The challenge of being diagnosed and treated for ductal carcinoma in situ (DCIS)

Kennedy¹,

Harcourt²,

Rumsey³

2008

European Journal of Oncology Nursing

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Following the introduction of the National Health Service Breast Screening Programme (NHSBSP) in the UK increasing numbers of women are diagnosed with ductal carcinoma in situ (DCIS). In DCIS, the cancer cells are confined to the ducts of the breast but considerable uncertainty surrounds the condition. Patients are often reassured that it is non-invasive and not life-threatening but they are recommended similar treatments to patients with invasive breast cancer. Little research has investigated the psychosocial impact of DCIS; therefore the aim of this qualitative study was to explore women's experiences of the condition. Semi-structured interviews were conducted with a purposive sample of 16 women previously diagnosed and treated for DCIS. Thematic analysis identified six key themes: 1) Invisibility of DCIS, 2) Uncertainty, 3)Perceptions of DCIS, 4) Acceptance of Treatment, 5) Social Support and 6) Moving On.The results highlight the substantial challenges faced by women diagnosed with DCIS.These findings have clear significance for healthcare professionals, especially specialist nurses, who work closely with DCIS patients.

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Section: Introductionmentioning

confidence: 99%

The challenge of being diagnosed and treated for ductal carcinoma in situ (DCIS)

Kennedy¹,

Harcourt²,

Rumsey³

2008

European Journal of Oncology Nursing

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“…It falls on a continuum from normal cells in the epithelium lining the ducts, to atypical ductal hyperplasia made up of cells that are dividing and starting to look abnormal, to DCIS when they are starting to look just like cancer cells but have not penetrated the basement membrane. When the cells penetrate the basement membrane, they become invasive ductal carcinoma (Erbas et al 2006). This is a cancer that was diagnosed relatively rarely in the era before mammography -in 1973, the incidence rate for women was 2.4 per 100,000 per yearbut mammography made more common: in 1992 it had risen to 15.8 per 100,000 (Erbas et al 2006, Ernster et al 1996.…”

Section: Ductal Carcinoma In Situ (Dcis)mentioning

confidence: 99%

“…When the cells penetrate the basement membrane, they become invasive ductal carcinoma (Erbas et al 2006). This is a cancer that was diagnosed relatively rarely in the era before mammography -in 1973, the incidence rate for women was 2.4 per 100,000 per yearbut mammography made more common: in 1992 it had risen to 15.8 per 100,000 (Erbas et al 2006, Ernster et al 1996. Out of all the tumors identified in mammography screening programs, DCIS makes up about 15-25% of them.…”

Section: Ductal Carcinoma In Situ (Dcis)mentioning

confidence: 99%

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Small Tumors as Risk Factors not Disease

Schwartz¹

2014

Philos. of Sci.

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Abstract:I argue that ductal carcinoma in situ (DCIS), the tumor most commonly diagnosed by breast mammography, cannot be confidently classified as cancer, i.e. as pathological. This is because there may not be dysfunction present in DCIS -as I argue based on its high prevalence and the small amount of risk it conveys -and thus DCIS may not count as a disease by dysfunction-requiring approaches, such as Boorse's Biostatistical Theory and Wakefield's Harmful Dysfunction Account. Patients should decide about treatment for DCIS based on the risks it poses and the risks and benefits of treatment, not on its disease status. Acknowledgments:Thanks to Chris Boorse, Dan Hausman, Eric Meslin, and Greg Sachs for discussion. Thanks to Anya Plutynski for inviting me to participate in this panel and Miriam Solomon for her commentary.

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“…The reported prevalence of undiagnosed DCIS in autopsy studies, of approximately 9 %, has been used to suggest that a larger reservoir of DCIS may exist in the population [6].…”

Section: Introductionmentioning

confidence: 99%

Ductal Carcinoma In Situ of the Breast

Vaidya

2013

Indian J Surg

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Ductal carcinoma in situ (DCIS) of the breast is a potentially invasive neoplasm. Risk factors include high estrogen states such as use of oral contraceptive (OC) pills, nulliparity, advanced age at first birth, and also family history and genetic mutations. The incidence of this usually clinically silent condition has risen in the past few decades due to widespread screening and diagnostic mammography, with final diagnosis confirmed by biopsy. At present, treatment options include total or simple mastectomy or lumpectomy with radiation. Adjuvant therapy includes antiestrogens like tamoxifen and human epidermal growth factor receptor 2 (HER2) suppression therapy. With the latest advances in chemotherapy and better understanding on the pathogenesis of the lesion, it is anticipated that more effective modalities of treatment may soon be available.

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The natural history of ductal carcinoma in situ of the breast: a review

Cited by 320 publications

References 88 publications

The challenge of being diagnosed and treated for ductal carcinoma in situ (DCIS)

The challenge of being diagnosed and treated for ductal carcinoma in situ (DCIS)

Small Tumors as Risk Factors not Disease

Ductal Carcinoma In Situ of the Breast

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