THE NATURAL HISTORY OF CERVICAL CARCINOMA <i>IN SITU</i>

Green, G. H.; Donovan, John W.

doi:10.1111/j.1471-0528.1970.tb03401.x

Cited by 37 publications

(11 citation statements)

References 18 publications

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“…Intra-epithelial lesions can be found associated with CC, and are probably the precursors of adjacent invasive lesions. However, the large majority of CINs -even high-grade lesions -spontaneously regress, which indicates that additional events to those observed in the most commonly encountered CINs, which do not evolve into cancer, are required for conversion to malignancy [4].…”

mentioning

confidence: 99%

Loss of Heterozygosity on the Short Arm of Chromosome 3 in Cervical Intra-Epithelial Neoplasia without Concomitant Cervical Carcinoma

Fouret¹,

Dabit

Mergui

et al. 1998

Pathobiology

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Losses of heterozygosity on the short arm of chromosome 3p are common in cervical carcinomas in the 3p13-3p21 region, and can be observed in intra-epipthelial lesions accompanying cervical cancers. As a preliminary attempt to determine whether these losses can be observed in intra-epithelial cervical lesions without concomitant invasive carcinoma, we have used two microsatellite markers located at the two most frequently deleted segments of the 3p13-3p21 region. We have studied 36 cases of grade II and grade III cervical intra-epithelial neoplasias obtained by conisation biopsies and 30 cases of cervical carcinoma including 3 micro-invasive squamous cell carcinomas. We found loss of heterozygosity or microsatellite instability in 6 of 16 (38%) and 9 of 23 (39%) informative cases of cervical carcinoma at 3p13 and 3p21, respectively. Four of 27 (15%) cases of cervical intra-epithelial neoplasia showed loss of heterozygosity at 3p13, whereas loss of heterozygosity or microsatellite instability at 3p21 was found in 5 of 19 cases (26%). No relationship was found between 3p loss of heterozygosity and human papillomavirus infection. In conclusion, losses of heterozygosity at 3p13 and 3p21 occur in premalignant lesions without concomitant invasive lesions. The prevalence and precise extent of these losses should be established by a more extensive analysis.

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mentioning

confidence: 99%

Loss of Heterozygosity on the Short Arm of Chromosome 3 in Cervical Intra-Epithelial Neoplasia without Concomitant Cervical Carcinoma

Fouret¹,

Dabit

Mergui

et al. 1998

Pathobiology

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“…In 1966 Green gained the approval of the hospital medical committee for a study in which no further treatment would be offered to a group of women in whom a histologic diagnosis of CIS of the cervix had been established by a representative biopsy with minimal disturbance of the lesion. While Green's publications through the 1960s and 1970s 3,4 appeared to confirm his theory, an independent reanalysis of data from the same group of women by McIndoe et al in 1984 demonstrated a 25-fold increased risk of cervical cancer in women with persistent cytologic abnormalities as compared with women with normal cytologic follow-up. 5 We reanalyzed the original material-by reviewing medical records, histopathologic slides and cytology smears-and performed linkages with cancer registries, death registries and electoral rolls primarily to assess, in relation to the women's treatment, the longterm risk of cancer of the lower genital tract in this cohort (McCredie et al, in preparation).…”

mentioning

confidence: 91%

“…Green's study 4 involved withholding definitive treatment from a group of women with a histologic diagnosis of CIN 3 so that he could follow the natural history of the disease. Although many of the women subsequently had positive smears, Green either did no biopsy or performed only inadequate biopsies to check for invasion.…”

Section: Review Of Cytologic Slidesmentioning

confidence: 99%

Review of Cytologic Slides from the National Women’s Hospital, New Zealand, Cohort of Women with Cervical Intraepithelial Neoplasia 3 Diagnosed in 1955–1976

McCredie

Medley²,

Sharples³

et al. 2006

Acta Cytologica

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“…These women were followed up during 13 to 141 months, with a mean of 53 months (4.42 years). None of these women developed invasive cancer during the follow-up period [37]. Interpreting the results from the clinical study by an inappropriate model led Professor Green to dismiss the common opinion that CIS is a pre-stage of cancer and to question the need for any treatment at all of CIS.…”

Section: Pred T T Pred T T Births Tmentioning

confidence: 99%

“…The conceptual description quoted here is taken from [37], but we have changed the denotation of the sojourn time from m to D.…”

Section: Conceptual Modelmentioning

confidence: 99%

The Full Potential of Continuous System Simulation Modelling

Gustafsson¹,

Sternad²,

Gustafsson³

2017

OJMSi

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Continuous System Simulation (CSS) is a powerful way to study the behaviour of differential-algebraic equation models. Differential-algebraic equation modelling goes back to Newton and works well for models of e.g. physical systems where stochasticity plays almost no role, and where only a single attribute of an object is studied over time. However, when results from a deterministic CSS model are compared with results from a Discrete Event Simulation (DES) model, they are often inconsistent. The reasons behind this CSS-DES inconsistency are nowadays well understood. In this paper, we demonstrate that a CSS model can contain both continuous state variables (compartments) that change continuously over time and discrete state variables (also compartments) that model discrete entities and change by integer amounts. In both cases, the time-slicing method is used to advance time. Furthermore, stochasticity can and should play the same role in CSS as it does in DES. This paper first explains how a well-defined conceptual model can be stepwise transformed in a consistent way into a CSS model. These transformation steps provide insights into how to construct a consistent CSS model. In short, this is about preserving uncertainties, attributes and dynamic properties. An additional benefit of this approach is that continuous and discrete sub-models can interact within the same model, without having to combine different types of simulation languages, types of time handling and incongruent concepts. To facilitate the use and understanding of stochastic CSS, this paper is also intended to serve as a guide to performing consistent CSS modelling and simulation. Furthermore, an open source tool for collecting and analyzing the outputs from a stochastic CSS model and analyzing and presenting the results in statistical form is also developed and made available to the reader.

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THE NATURAL HISTORY OF CERVICAL CARCINOMA IN SITU

Cited by 37 publications

References 18 publications

Loss of Heterozygosity on the Short Arm of Chromosome 3 in Cervical Intra-Epithelial Neoplasia without Concomitant Cervical Carcinoma

Loss of Heterozygosity on the Short Arm of Chromosome 3 in Cervical Intra-Epithelial Neoplasia without Concomitant Cervical Carcinoma

Review of Cytologic Slides from the National Women’s Hospital, New Zealand, Cohort of Women with Cervical Intraepithelial Neoplasia 3 Diagnosed in 1955–1976

The Full Potential of Continuous System Simulation Modelling

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