The natural disease course of ankylosing spondylitis

Carette, Simon; Graham, D.; Little, Hugh; Rubenstein, Joel; Rosen, Philip

doi:10.1002/art.1780260210

Cited by 218 publications

(84 citation statements)

References 12 publications

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“…This is reflected by its inclusion in the modified New York Criteria for the classification of ankylosing spondylitis (AS) and in the core set of domains for the evaluation of patients with SpA in clinical practice and trials, as defined by the Assessment of SpondyloArthritis international Society (ASAS) (1). A study on the natural course of AS conducted in the pre-biologic agent era described that in the long term more than half of all patients will develop moderate to severe impairment of spinal mobility (2). Spinal mobility is one of the central outcomes included in observational and treatment studies in axial SpA (3,4) and is a predictor of poor prognosis (3).…”

Section: Introductionmentioning

confidence: 99%

Hierarchy of Impairment of Spinal Mobility Measures in Ankylosing Spondylitis: Twelve‐Year Data

Ramiro

Landewé

Heijde

et al. 2015

Arthritis Care & Research

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Objective. To investigate which spinal mobility measures (SMMs) are most frequently impaired in patients with ankylosing spondylitis (AS), whether a hierarchy of impairment can be established, and whether assessing fewer measures sufficiently captures impairment in spinal mobility. Methods. Patients from the Outcome in Ankylosing Spondylitis International Study were followed up for 12 years. SMMs were considered impaired when falling below predefined cutoffs, derived from normal individuals. The proportion of patients in whom each SMM was impaired was calculated using baseline observation. In patients with ‡1 impaired SMM, we investigated how often impairment in spinal mobility would be missed if only a fixed number of SMMs was assessed. Analyses were repeated using all 12-year observations. Results. A total of 216 patients were included (70% males). Lateral spinal flexion (LSF) was the most frequently impaired measure, followed by the modified Schober (mSchober) test, tragus-to-wall, cervical rotation, intermalleolar distance, and chest expansion measures, respectively. This hierarchy was strikingly consistent over time, and independent of sex, symptom duration, and presence of syndesmophytes. In patients with ‡1 impaired SMM, LSF was impaired most frequently (86%), followed by the mSchober test (58%). If only LSF was measured, 14% of patients with impairment in any SMM would be missed; if additionally the mSchober test was measured, 9% would be missed. Conclusion. LSF followed by the mSchober test are the most frequently impaired mobility measures in AS, reflecting an earlier involvement of the lumbar spine, followed by involvement of the thoracic and cervical spine. In clinical practice LSF and the mSchober test suffice to screen impairment in spinal mobility.

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Section: Introductionmentioning

confidence: 99%

Hierarchy of Impairment of Spinal Mobility Measures in Ankylosing Spondylitis: Twelve‐Year Data

Ramiro

Landewé

Heijde

et al. 2015

Arthritis Care & Research

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“…[5] It mostly affects men, especially in their sexually active ages. Some studies have suggested that progression in AS is most rapid in the first 10 years of the disease, [6,7] and this fact can greatly influence sexual activity. Otherwise, sexual problems created by both physical changes of the illness and its attendant distress not only affect these patients, but also their partners.…”

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confidence: 99%

Assessment of Sexual Functions in Male Patients with Ankylosing Spondylitis Compared with Healthy Controls

Rezvanı

2013

Turk J Rheumatol

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Amaç: Bu çalışmada, ankilozan spondilitin (AS), erkek hastalarda seksüel fonksiyon üzerindeki etkisi, araştırıldı, sonuçlar sağlıklı erkek kontrollerle karşılaştırıldı ve hastalık ile ilgili değişkenlerle olan ilişkisi belirlendi. Objectives: This study aims to investigate the impact of ankylosing spondylitis (AS) on sexual functions in male patients, to compare the results with healthy male controls, and to identify the associations with disease-related variables. Hastalar ve yöntemler: Patients and methods:A total of 39 male patients with AS (mean age 38 years; range 27 to 52 years) and 27 healthy male subjects (mean age 30 years; range 23 to 45 years) were included in the study. The Bath Ankylosing Spondylitis Metrology Index (BASMI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Short Form 36 (SF-36) and the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire were used for those with AS, while the International Index of Erectile Function (IIEF) and the Beck Depression Inventory (BDI) were utilized for all the study subjects. Results:The frequency of erectile dysfunction in the male patients with AS and the healthy controls was 43.6% and 51.9%, respectively. No statistically significant differences were found with regard to demographic characteristics, the IIEF, or the BDI scores between the two groups (p>0.05). No significant correlation was found between any domain of the IIEF and the AS indices or laboratory parameters. However, erectile function, overall satisfaction, the total IIEF, and the level of erectile dysfunction were found to be correlated with the BDI. Conclusion:Sexual dysfunction is common in male patients with AS; however, we could not find any statistically significant differences between them and the healthy male controls in terms of sexual functions. Sexual dysfunction in male patients with AS seems to be associated with an unfavorable psychological status.

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“…It has been linked to HLA B-27. Extra-arti-cular involvement is frequent and includes anterior uveitis, cardiac manifestations, pulmonary fibrosis, arachnoiditis, 9 cauda equina syndrome, and amyloidosis [10][11][12] . It also has been associated with ulcerative colitis, regional enteritis, psoriasis, multiple sclerosis, Reiter's disease, and Behçet's disease.…”

mentioning

confidence: 99%

Ankylosing spondylitis and central core disease: case report

Scola

Lin

Iwamoto

et al. 2003

Arq. Neuro-Psiquiatr.

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-Ankylosing spondylitis (AS) is an inflammatory disorder of unknown cause that primarily affects the axial skeleton. Neurological manifestations of AS are usually related to spinal deformities. Previous studies of the paraspinal muscles of AS patients showed muscle fiber atrophy, and core fibers. On the other hand, central core disease (CCD) is a genetic condition that primarily involves the skeletal muscles, but can present articular deformities secondary to muscular weakness. We report the case of a 45-year-old man with clinical and radiological diagnosis of AS and proximal muscular weakness in the lower limbs. Needle electromyography showed myopathic features and nerve conduction study was normal. Muscle biopsy disclosed almost complete predominance of type-1 fibers, and fibers with central cores. This is the first report of AS and CCD. Whether central core myopathy is coincidental or a new association with AS is discussed.KEY WORDS: ankylosing spondylitis, central core disease, muscle biopsy. Espondilite anquilosante e doença do core central: relato de casoRESUMO -A espondilite anquilosante (EA) é desordem inflamatória de causa desconhecida que afeta primariamente o esqueleto axial. Estudos prévios dos músculos para-espinhais em pacientes acometidos de EA demonstraram atrofia de fibras musculares e fibras com core central. Por outro lado, a doença do core central (DCC) é condição genética que envolve primariamente a musculatura esquelética, podendo acarretar deformidades articulares devido a fraqueza muscular. Relatamos o caso de um paciente de 45 anos com diagnóstico clínico e radiológico de espondilite anquilosante e fraqueza muscular proximal nos membros inferiores. A eletromiografia de agulha mostrou padrão miopático e a biópsia muscular evidenciou predominância quase total de fibras tipo 1 e fibras com cores, compatível com DCC. Este é o primeiro relato de EA e DCC. Discutimos se a EA é apenas coincidência ou uma nova associação com a DCC. PALAVRAS-CHAVE: espondilite anquilosante, doença do core central, biópsia muscular.

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The natural disease course of ankylosing spondylitis

Cited by 218 publications

References 12 publications

Hierarchy of Impairment of Spinal Mobility Measures in Ankylosing Spondylitis: Twelve‐Year Data

Hierarchy of Impairment of Spinal Mobility Measures in Ankylosing Spondylitis: Twelve‐Year Data

Assessment of Sexual Functions in Male Patients with Ankylosing Spondylitis Compared with Healthy Controls

Ankylosing spondylitis and central core disease: case report

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