The Natural Course of Ulcerative Proctitis in Japan: Disease Extension and Related Factors

Systematic review with meta‐analysis: proximal disease extension in limited ulcerative colitis

“…After exclusion of duplicates, 4443 records were screened. After reviewing the title and abstract and if necessary the full publications, 41 relevant studies were retrieved for full review out of 139 full‐text articles were assessed for eligibility. Studies with no baseline endoscopic assessment, less than 13 cases or with insufficient information on patients were excluded.…”

“…Characteristics of the 41 studies fulfilling inclusion criteria are detailed in Table . Twelve of the 41 studies were abstracts and 27 were retrospective studies. Twenty‐four studies were from Europe, seven from North America, seven from Asia and one from Africa .…”

“…Twelve of the 41 studies were abstracts and 27 were retrospective studies. Twenty‐four studies were from Europe, seven from North America, seven from Asia and one from Africa . Accrual period for these studies, reported in 38 studies of 41 ranged from 1953 to 2016.…”

“…Ulcerative colitis overall rate of extension was reported in 30 studies with information on rate of extension from proctitis (E1) to left side colitis (E2) in 11 studies from left side colitis (E2) to pancolitis (E3) in 13 studies and from proctitis (E1) to pancolitis (E3) in 10 studies Information on extension over time (at 5 and 10 years) was reported in 11 studies, of which 3 were not included in the meta‐analysis because of insufficient information.…”

“…EIMs were reported in seven studies and tobacco usage in 12 studies . Age at diagnosis was reported in 20 studies with a median age of 37.1 years (10.6‐69).…”