The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis

Liu, Xiaomin; Zhang, Yuwei; Chu, Yi; Zhao, Xuemei; Mao, Liufeng; Zhao, Shiting; Lin, Shaoqiang; Hui, Xiaoyan; Gu, Ping; Xu, Yong; Loomes, Kerry M.; Tang, Shibing; Nie, Tao; Wu, Donghai

doi:10.1016/j.bbrc.2021.01.080

Cited by 5 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural products always have an outstanding regulatory function in the tumor microenvironment, so researchers conducted extensive studies on the effects of natural products on adipocytes cell cycle and regulatory factors. For example, a natural product of small molecules called Rutaecarpine is able to reduce the incidence of adipocyte-associated obesity by regulating the AMPK signal pathway ( 192 ). Cancer is a disease that affects the homeostasis of the whole organism.…”

Section: Mechanisms Underlying Natural Products Remodeling Tumor Micr...mentioning

confidence: 99%

Remodeling tumor microenvironment with natural products to overcome drug resistance

Zhang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand to find safer and more effective anticancer strategy for cancer patients. Natural products, have the advantage of low toxicity and multiple action targets, are always used in the treatment of cancer prevention in early stage and cancer supplement in late stage. Tumor microenvironment is necessary for cancer cells to survive and progression, and immune activation is a vital means for the tumor microenvironment to eliminate cancer cells. A number of studies have found that various natural products could target and regulate immune cells such as T cells, macrophages, mast cells as well as inflammatory cytokines in the tumor microenvironment. Natural products tuning the tumor microenvironment via various mechanisms to activate the immune response have immeasurable potential for cancer immunotherapy. In this review, it highlights the research findings related to natural products regulating immune responses against cancer, especially reveals the possibility of utilizing natural products to remodel the tumor microenvironment to overcome drug resistance.

show abstract

Section: Mechanisms Underlying Natural Products Remodeling Tumor Micr...mentioning

confidence: 99%

Remodeling tumor microenvironment with natural products to overcome drug resistance

Zhang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Zhou et al (2019) found that liraglupeptide can induce the differentiation of brown adipocytes in skeletal muscle, including the expression of UCP1 and PRDM16 proteins, and improve insulin sensitivity through multiple pathways, thereby reducing inflammation, enhancing fatty acid oxidation, and inducing adaptive thermogenesis (Zhou et al, 2019). Compound C (an AMPK inhibitor) downregulated PRDM16 in adipocytes, and the effect of rutaecarpine on adipocyte browning was eliminated (Liu et al, 2021b). Liu X. et al (2021b proposed that rutaecarpine may play a therapeutic role in obesity using AMPK/PRDM16 signaling (Liu et al 2021b).…”

Section: Prdm16 May Serve As a Potential Therapeutic Target In Obesit...mentioning

confidence: 99%

“…Compound C (an AMPK inhibitor) downregulated PRDM16 in adipocytes, and the effect of rutaecarpine on adipocyte browning was eliminated (Liu et al, 2021b). Liu X. et al (2021b proposed that rutaecarpine may play a therapeutic role in obesity using AMPK/PRDM16 signaling (Liu et al 2021b). Pan et al (2019) found that resveratrol, as a natural stilbene with antiobesity effects, can enhance the expression of thermogenic-related proteins UCP1 and PRDM16 by activating SIRT1/PGC-1α (Pan et al, 2019).…”

Section: Prdm16 May Serve As a Potential Therapeutic Target In Obesit...mentioning

confidence: 99%

PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

et al. 2022

View full text Add to dashboard Cite

Given that obesity and diabetes have been major public health concerns and that disease morbidities have been rising continuously, effective treatment for these diseases is urgently needed. Because adipose tissue metabolism is involved in the progression of obesity and diabetes, it might be efficient to target adipocyte metabolic pathways. Positive regulatory domain zinc finger region protein 16 (PRDM16), a transcription factor that is highly expressed in adipocytes, plays a key role in adipose tissue metabolism, such as the browning and thermogenesis of adipocytes, the beigeing of adipocytes, the adipogenic differentiation of myoblasts, and the conversion of visceral adipocytes to subcutaneous adipocytes. Furthermore, clinical and basic studies have shown that the expression of PRDM16 is associated with obesity and diabetes and that PRDM16 signaling participates in the treatment of the two diseases. For example, metformin promotes thermogenesis and alleviates obesity by activating the AMPK/αKG/PRDM16 signaling pathway; rosiglitazone alleviates obesity under the synergistic effect of PRDM16; resveratrol plays an antiobesity role by inducing the expression of PRDM16; liraglupeptide improves insulin resistance by inducing the expression of PRDM16; and mulberry leaves play an anti-inflammatory and antidiabetes role by activating the expression of brown fat cell marker genes (including PRDM16). In this review, we summarize the evidence of PRDM16 involvement in the progression of obesity and diabetes and that PRDM16 may be a promising therapy for obesity and diabetes.

show abstract

Substantial solubility and fluorescence property changes upon inclusion of rutaecarpine in cucurbit[7]uril: Kinetics and thermodynamics of binding

Miskolczy,

Megyesi,

Turczel

et al. 2024

Journal of Molecular Liquids

View full text Add to dashboard Cite

The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis

Cited by 5 publications

References 32 publications

Remodeling tumor microenvironment with natural products to overcome drug resistance

Remodeling tumor microenvironment with natural products to overcome drug resistance

PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

Substantial solubility and fluorescence property changes upon inclusion of rutaecarpine in cucurbit[7]uril: Kinetics and thermodynamics of binding

Contact Info

Product

Resources

About