“…Patch testing of referred patients demonstrated positive reactions to methacrylates and additives relevant to resin based materials, although the most frequent allergens were nickel, gold, cobalt, palladium, mercury, and chromium. A survey by the UK registry indicated that the number of adverse reactions caused by resin based materials, amalgam alternatives included, was about 14 % of the total number of patient reactions (Scott et al 2004). …”