The National Strongyloides Working Group in Australia 10 workshops on: commendations and recommendations

Ross, Kirstin; Bradbury, Richard S.; Garrard, Tara A.; O’Donahoo, Francis J.; Shield, Jennifer; Page, Wendy; Miller, Adrian; Robertson, Gemma; Judd, Jenni; Speare, Rick

doi:10.1111/1753-6405.12611

Cited by 11 publications

(14 citation statements)

References 23 publications

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“…Reviews examining other barriers to strongyloidiasis control in Indigenous communities have identified several points for intervention, including the need for improved reporting protocols, increased testing of at-risk individuals, health professional engagement, and community-based monitoring and control programs [ 8 , 18 , 42 ]. Collaborative community-based initiatives incorporating mass deworming, infrastructure improvements, and culturally safe health education ( Figure 6 ) have demonstrated significant reductions in Strongyloides seroprevalences [ 16 , 18 , 42 ]. One Western Australian study saw the seropositivity in 259 Indigenous adults fall from 35.3% to 5.8% in three years using these strategies [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Within community-based initiatives, further research is needed to inform practices relating to the testing and treatment of Indigenous children. Universal testing of Indigenous people living in endemic areas has been recommended [ 18 , 42 ]. The logistical challenges of implementing universal paediatric testing are substantial in our context.…”

Section: Discussionmentioning

confidence: 99%

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Paediatric Strongyloidiasis in Central Australia

Wilson

Fearon

2018

TropicalMed

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Few published studies are available describing the prevalence of paediatric strongyloidiasis in endemic areas within Australia. This literature review and exploratory clinical audit presents the first seroprevalence data for paediatric patients in Central Australia. A total of 16.1% (30/186) of paediatric inpatients tested for Strongyloides stercoralis in 2016 were seropositive (95% CI: 11.5% to 22.1%). Eosinophilia of unknown aetiology was the most common indication for testing (91.9%). Seropositive patients were significantly more likely to reside in communities outside of Alice Springs (p = 0.02). Seropositive patients were noted to have higher mean eosinophil counts with a mean difference of 0.86 × 109/L (95% CI: 0.56 to 1.16, p < 0.0001), although the limited utility of eosinophilia as a surrogate marker of strongyloidiasis has been described previously. All seropositive patients were Indigenous. There was no significant difference in ages between groups. There was a male predominance in the seropositive group, although this was not significant (p = 0.12). Twelve patients had known human T-lymphotropic virus 1 (HTLV-1) status and all were seronegative. Further research describing the epidemiology of strongyloidiasis in Central Australia is required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Paediatric Strongyloidiasis in Central Australia

Wilson

Fearon

2018

TropicalMed

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“…A marked reduction in the prevalence of strongyloides at 6 and 18 months was demonstrated using this approach [ 12 ]. Such a strategy however, would require the active participation of affected communities and public health authorities alike, and agreement on the need for such a program has not yet been reached [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Control of chronic Strongyloides stercoralis infection in an endemic community may be possible by pharmacological means alone: Results of a three-year cohort study

2017

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ObjectivesTo assess the effect of treatment with ivermectin on the prevalence of S. stercoralis infection in an Australian Aboriginal population over a three year period, and to assess the validity of using a lower ELISA cut-off in diagnosis.MethodsA three-year cohort study of 259 adult Australian Aboriginals living in a remote community in northern Australia. S stercoralis infection was diagnosed using commercial ELISA testing, and employed a lower threshold for treatment than that recommended. Follow up was conducted at 6 months and 3 years following ivermectin treatment.FindingsTreatment with ivermectin was highly effective and resulted in a sustained fall in the prevalence of infection in the study group (Initial prevalence 35.3%, 3 year prevalence 5.8%, McNemar’s chi2 = 56.5, p<0.001). Results of treatment suggested use of a lower ELISA threshold for treatment was valid in this setting. Follow up identified a small group of subjects with persistently positive ELISA serology despite repeated treatment.InterpretationControl of S. stercoralis infection in this cohort appears to be feasible using pharmacological treatment alone.

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“…[6][7][8][9][10][11] This seeking behavior frequently relates to the perception of previously acquired information as inadequate, 8,12,13 confusing 14,15 or conflicting. 16 Consequently, a person may seek information about vaccination to feel reassured about a decision, get a 'second opinion' or prepare for a consultation with a healthcare professional, 16,17 sometimes with the intention of challenging a recommendation. 18,19 The content of such information gathered through seeking often centers around safety concerns related to a specific vaccine, 16 the signs, and symptoms of a disease the vaccine is intended to prevent 13 or gaining information on aspects of trust and morality such as financial interests, misconduct, and intentions of individuals within the healthcare system or pharmaceutical industry.…”

mentioning

confidence: 99%

“…16 Consequently, a person may seek information about vaccination to feel reassured about a decision, get a 'second opinion' or prepare for a consultation with a healthcare professional, 16,17 sometimes with the intention of challenging a recommendation. 18,19 The content of such information gathered through seeking often centers around safety concerns related to a specific vaccine, 16 the signs, and symptoms of a disease the vaccine is intended to prevent 13 or gaining information on aspects of trust and morality such as financial interests, misconduct, and intentions of individuals within the healthcare system or pharmaceutical industry. 18 As such, the information gained through vaccine information-seeking can be categorized as information pertaining to trust and personal risk management.…”

mentioning

confidence: 99%

Do previously held vaccine attitudes dictate the extent and influence of vaccine information-seeking behavior during pregnancy?

Clarke

Sirota

Paterson

2019

Human Vaccines & Immunotherapeutics

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Pregnancy represents a high information need state, where uncertainty around medical intervention is common. As such, the pertussis vaccination given during pregnancy presents a unique opportunity to study the interaction between vaccine attitudes and vaccine information-seeking behavior. We surveyed a sample of pregnant women (N = 182) during early pregnancy and again during late pregnancy. The variables of vaccine confidence and risk perception of vaccination during pregnancy were measured across two questionnaires. Additional variables of decision conflict and intention to vaccinate were recorded during early pregnancy, while vaccine information-seeking behavior and vaccine uptake were recorded during late pregnancy. 88.8% of participants reported seeking additional information about the pertussis vaccine during pregnancy. Women that had a lower confidence in vaccination (p = .004) and those that saw the risk of pertussis disease as high compared to the risk of side effects from the pertussis vaccination during pregnancy (p = .004) spent significantly more time seeking information about the pertussis vaccination. Women's perception of risk related to vaccination during pregnancy significantly changed throughout the pregnancy (t(182) = 4.685 p< .001), with women perceiving the risk of pertussis disease higher as compared to the risk of side effects from the vaccine as the pregnancy progresses. The strength and influence of information found through seeking was predicted by intention to vaccinate (p = .011). As such, we suggest that intention to vaccinate during early pregnancy plays a role in whether the information found through seeking influences women towards or away from vaccination.

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The National Strongyloides Working Group in Australia 10 workshops on: commendations and recommendations

Cited by 11 publications

References 23 publications

Paediatric Strongyloidiasis in Central Australia

Paediatric Strongyloidiasis in Central Australia

Control of chronic Strongyloides stercoralis infection in an endemic community may be possible by pharmacological means alone: Results of a three-year cohort study

Do previously held vaccine attitudes dictate the extent and influence of vaccine information-seeking behavior during pregnancy?

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