-Coronary artery disease is the leading cause of death in the UK with a high clinical, social and economic burden. The management of acute coronary syndromes is rapidly evolving and clinicians are constantly challenged with incorporating new clinical pathways and guidelines into their practices. It is important for clinicians to have a sound working knowledge of acute coronary syndromes, and be updated on the emerging evidence to guide therapy and improve outcomes in these patients.KEY WORDS: acute coronary syndromes, coronary artery disease, myocardial infarction
IntroductionOver recent years, there has been overwhelming trial data, which has had significant impact on our management of patients with acute coronary syndromes. There is greater emphasis on earlier reperfusion with different strategies in acute myocardial infarction (MI), development and greater use of novel antithrombotic agents, and greater emphasis on secondary prevention and cardiac rehabilitation. This review article serves to update physicians both in the primary and secondary care setting in this rapidly evolving field of acute coronary syndromes.
Sources and selection criteriaA literature search was conducted using PubMed/ Medline, EMBASE and Cochrane databases using coronary artery disease (CAD), acute coronary syndromes and MI as keywords. References of recent major articles and key reviews were also researched, and articles were accessed where necessary.
ClassificationAcute coronary syndromes include unstable angina (USA), non-ST segment elevation MI (NSTEMI) and ST segment elevation MI (STEMI). Acute coronary syndromes with persistent STEMI generally require urgent reperfusion therapy. Those without persistent ST-elevation represent a continuum from USA to NSTEMI and can be further classified on the basis of troponin release, a biochemical marker of myocardial cell death (Fig 1).
EpidemiologyAn estimated 2.7 million people in the UK have CAD which accounts for over 105,000 deaths per year. Approximately 1.3 million people in the UK have had a MI, 2 million people suffer from angina, and over 230,000 new MIs are diagnosed every year. 1 Over the last decade, the proportion of patients presenting with STEMI has fallen, while there has been an increase in USA and NSTEMI. 2 Explanations for this apparent change are probably multifactorial, but relate to advances in therapy, risk factor reduction, better primary and secondary preventative strategies and appropriate coronary revascularisation. In addition, the growing use of troponin assays, which have an increased overall diagnostic sensitivity for MI, has facilitated more effective early treatment.
Reperfusion therapy in STEMI
ThrombolysisFor over two decades, thrombolysis has been the cornerstone in the acute management of STEMI, s ORIGINAL PAPERS 42