The National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Network Randomized Clinical Trial in Progress

2. Classification and Diagnosis of Diabetes

“…The expected benefits to these pregnancies and offspring are inferred from intervention trials that focused on women with lower levels of hyperglycemia than identified using older GDM diagnostic criteria and that found modest benefits including reduced rates of large-for-gestational-age births and preeclampsia (41,42). It is important to note that 80-90% of women being treated for mild GDM in two randomized controlled trials (whose glucose values overlapped with the thresholds recommended by the IADPSG) could be managed with lifestyle therapy alone.…”

2. Classification and Diagnosis of Diabetes

“…The expected benefits to these pregnancies and offspring are inferred from intervention trials that focused on women with lower levels of hyperglycemia than identified using older GDM diagnostic criteria and that found modest benefits including reduced rates of largefor-gestational-age births and preeclampsia (42,43). It is important to note that 80-90% of women being treated for mild GDM in two randomized controlled trials (whose glucose values overlapped with the thresholds recommended by the IADPSG) could be managed with lifestyle therapy alone.…”

722: First trimester fasting hyperglycemia and adverse pregnancy outcomes

“…Indeed, ϳ20% of fetuses already had signs of macrosomia (abdominal circumference above the 90% percentile in ultrasound exam) at the time the women were first referred for GDM treatment (14). Several recent studies (15)(16)(17) provide contemporary evidence that screening for and treating GDM is beneficial, and this evidence has bolstered the arguments of those who favor universal GDM testing. Nevertheless, outcomes found in the treatment arms of these studies as well as those observed in general clinical practice suggest that there is room for improvement even within the recommended testing paradigm.…”