The Nasal Smear for Eosinophils

Miller, Robert E.; Paradise, Jack L.; Friday, Gilbert A.; Fireman, Philip; Voith, Dorothy

doi:10.1001/archpedi.1982.03970470053015

Cited by 47 publications

(21 citation statements)

References 4 publications

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“…The grading were semiquantitative on a scale of 0 to 4 + [21]. It was shown that the presence of either nasal eosinophilic or basophilic metachromatic cell provides the best sensitivity and specificity [20,24]. Eosinophil scores and/or basophilic metachromatic cell scores of 1 was considered positive cut-off points for the diagnosis of allergic rhinitis.…”

Section: Methodsmentioning

confidence: 99%

Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

Said

Mchembe

Chalya

et al. 2012

BMC Ear Nose Throat Disord

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BackgroundAllergic rhinitis is one of the commonest atopic diseases which contribute to significant morbidity world wide while its epidemiology in Tanzania remains sparse. There was paucity of information regarding allergic rhinitis in our setting; therefore it was important to conduct this study to describe our experience on allergic rhinitis, associated co-morbidities and treatment outcome in patients attending Bugando Medical Centre.MethodsThis was descriptive cross-sectional study involving all patients with a clinical diagnosis of allergic rhinitis at Bugando Medical Centre over a three-month period between June 2011 and August 2011. Data was collected using a pre-tested coded questionnaire and analyzed using SPSS statistical computer software version 17.0.ResultsA total of 190 patients were studied giving the prevalence of allergic rhinitis 14.7%. The median age of the patients was 8.5 years. The male to female ratio was 1:1. Adenoid hypertrophy, tonsillitis, hypertrophy of inferior turbinate, nasal polyps, otitis media and sinusitis were the most common co-morbidities affecting 92.6% of cases and were the major reason for attending hospital services. Sleep disturbance was common in children with adenoids hypertrophy (χ2 = 28.691, P = 0.000). Allergic conjunctivitis was found in 51.9%. The most common identified triggers were dust, strong perfume odors and cold weather (P < 0.05). Strong perfume odors affect female than males (χ2 = 4.583, P = 0.032). In this study family history of allergic rhinitis was not a significant risk factor (P =0.423). The majority of patients (68.8%) were treated surgically for allergic rhinitis co morbidities. Post operative complication and mortality rates were 2.9% and 1.6% respectively. The overall median duration of hospital stay of in-patients was 3 days (2 – 28 days). Most patients (98.4%) had satisfactory results at discharge.ConclusionThe study shows that allergic rhinitis is common in our settings representing 14.7% of all otorhinolaryngology and commonly affecting children and adolescent. Sufferers seek medical services due to co-morbidities of which combination of surgical and medical treatment was needed. High index of suspicions in diagnosing allergic rhinitis and early treatment is recommended.

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Section: Methodsmentioning

confidence: 99%

Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

Said

Mchembe

Chalya

et al. 2012

BMC Ear Nose Throat Disord

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“…[279][280][281] The collected materials can be weighed or, in some paradigms, a sample of the secretions can be transferred from the collection media onto a glass slide, allowed to air dry, followed by staining and analysis of the cells present in the sample. The specimen can also be analyzed for the presence of various biomarkers as noted in detail later in this section.…”

Section: Methods For Collecting Secretions or Cells (A) Nasal Secrmentioning

confidence: 99%

Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

Doty

Cometto‐Muñiz

Jalowayski

et al. 2004

Critical Reviews in Toxicology

131

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“…Therefore, it is applicable only in specialist centers (1)(2)(3)(5)(6). Although these approaches have been widely used in the limited research setting, they have been less widely applied as a means of objectively monitoring nasal disease in the clinical trial and/or in real-life clinical practice setting (14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

“…However, few prospective studies evaluating the diagnostic utility of nasal cytology in allergic rhinitis have been performed (14)(15)(16)(17).…”

mentioning

confidence: 99%

Clinical Importance of Eosinophil Count in Nasal Fluid in Patients with Allergic and Non-Allergic Rhinitis

Lorenzo

Mansueto

Pacor

et al. 2009

Int J Immunopathol Pharmacol

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Eosinophil count in nasal fluid (ECNF) was used to differentiate nasal pathologies. Receiver Operating Characteristic (ROC) curve analysis and the area under the curve (AVC) were performed to evaluate the ECNF's accuracy in distinguishing allergic rhinitis (AR) from non-allergic rhinitis (NAR). We also evaluated the accuracy of ECNF in recognizing patients with mild and severe symptoms of rhinitis and patients with ineffective and effective clinical responses to antihistamines. 1,170 consecutive adult patients with a clinical history of rhinitis were studied. ECNF's median in AR was 6.0 and 2.0 in NAR and the best cut-off value was> 3.0, AVC = 0.75. ECNF's median in AR with mild nasal symptoms was 3.0 and 7.0 with severe symptoms, and the best cut-off value was 4.0, AV C =0.90. ECNF's median in NAR with mild nasal symptoms was 2.0 and 8.5 with severe symptoms, and the best cut-off value was> The most common diagnostic tests for allergic rhinitis are the Skin Prick Test (SPT) and the determination of serum allergen-specific IgE. A less common diagnostic tool is nasal cytology. Nasal cytology is generally employed by subspecialists or in research, but does not play a role in the routine evaluation of rhinitis (1). The techniques for obtaining cells for cytology in lavage, or brushings, have not been standardized as the criteria for evaluating cell counts (2). Nasal lavage is the reference method among adult patients (3). Brushing was compared to lavage among adults by Juliusson et al. They found a strong correlation between the two methods regarding the percentage of eosinophils

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The Nasal Smear for Eosinophils

Cited by 47 publications

References 4 publications

Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

Clinical Importance of Eosinophil Count in Nasal Fluid in Patients with Allergic and Non-Allergic Rhinitis

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