The nasal septum deformities in children and adolescents from Warsaw, Poland

Zielnik-Jurkiewicz, Beata; Olszewska-Sosińska, Olga

doi:10.1016/j.ijporl.2004.09.014

Cited by 37 publications

(26 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NSD constitutes one of several causes of nasal obstruction or mouth breathing, prompting many patients to visit otolaryngology departments. Although the development of NSD is assumed to be determined by genetic, cultural and environmental factors, the etiology behind the condition is not yet understood [9].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Mesenchymal Stem Cells Originating from the Bilateral Inferior Turbinate in Humans with Nasal Septal Deviation

et al. 2014

View full text Add to dashboard Cite

Background and objectivesNasal septal deviation (NSD) is often associated with overgrowth of the unilateral inferior turbinate. In vivo and in vitro studies indicate that human mesenchymal stem cells (MSCs) are able to differentiate into multiple cell types, including osteoblasts. We tested the hypothesis that turbinate size affects human turbinate-derived MSC (hTMSCs) quantity, proliferation, and differentiation into osteogenic lineages, and that hypertrophic turbinates may predispose to NSD on the contralateral side.Subjects and MethodsThe hypertrophic and contralateral inferior turbinate tissues used in our study were obtained and cultured from the tissue discarded from 10 patients who underwent septoplasty and partial turbinectomy. After isolating the hTMSCs from both turbinates, the cells were enumerated using an automated cell counter. The expression of surface markers for MSCs over four passages was assessed by fluorescent-activated cell sorting analysis (FACS), and cell proliferation was assessed using a cell counting kit (CCK)-8 according to turbinate size. In addition, osteogenic differentiation of hTMSCs was identified using alkaline phosphatase (ALP) and alizarin red S staining, after which osteoblastic gene expression was evaluated.ResultsThere was no significant difference in the number of hTMSCs. FACS analysis revealed that the hTMSCs were negative for CD14, CD19, CD34, and HLA-DR, and positive for CD29, CD73, and CD90, representing a characteristic MSC phenotype, with no significant difference between the two groups. The cellular proliferation and osteogenic differentiation potential of the hTMSCs were also not significantly different between the two groups.ConclusionsWe conclude that turbinate size does not affect the characterization, proliferation, and osteogenic differentiation potential of hTMSCs in vitro test, and therefore should not affect the clinical decision of whether to use autologous or allogenic hTMSCs. However, more experiments are required to definitively state the relationship of hTMSCs with turbinate size or the process NSD in humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Characteristics of Mesenchymal Stem Cells Originating from the Bilateral Inferior Turbinate in Humans with Nasal Septal Deviation

et al. 2014

View full text Add to dashboard Cite

show abstract

“…This can be developmental or acquired due to nasal trauma. A statistically significant higher incidence of nasal septal deformities has been shown with a history of nasal injury (Zielnik-Jurkiewicz, 2006) Fig. 2.…”

Section: Nasal Septal Deviationmentioning

confidence: 90%

Endoscopy in the Evaluation and Management of the Pediatric Airway

Jatana¹,

Rastatter²

2011

Advances in Endoscopic Surgery

View full text Add to dashboard Cite

“…In a child, the nose is soft and distensible, with relatively more mucosa and lymphoid tissue than in the adult (7). Deviation of the nasal septum occurs in all ages of children and may be the result of nasal injury or irregular development of the nasomaxillary complex (8). Racial differences in the dimensions of the nasal cavity have also been described (9).…”

Section: Nosementioning

confidence: 99%

Anatomy and assessment of the pediatric airway

Adewale

2009

Pediatric Anesthesia

106

View full text Add to dashboard Cite

SummaryAirway and respiratory complications are the most common causes of morbidity during general anesthesia in children. The airway changes in size, shape and position throughout its development from the neonate to the adult (1). Knowledge of the functional anatomy of the airway in children forms the basis of understanding the pathological conditions that may occur. This in turn allows a comprehensive assessment of the pediatric airway to take place, including a detailed medical history, clinical examination and specific investigative procedures.

show abstract

The nasal septum deformities in children and adolescents from Warsaw, Poland

Cited by 37 publications

References 13 publications

Characteristics of Mesenchymal Stem Cells Originating from the Bilateral Inferior Turbinate in Humans with Nasal Septal Deviation

Characteristics of Mesenchymal Stem Cells Originating from the Bilateral Inferior Turbinate in Humans with Nasal Septal Deviation

Endoscopy in the Evaluation and Management of the Pediatric Airway

Anatomy and assessment of the pediatric airway

Contact Info

Product

Resources

About